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T-050

Temazepam glucuronide lithium salt solution

Name: Temazepam glucuronide lithium salt solution
Brand: CERILLIAN

100 μg/mL in methanol (as free carboxylate), ampule of 1 mL, certified reference material, Cerilliant^®

别名:

Temazepam Glucuronide Solution

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关于此项目

经验公式（希尔记法）:

C₂₂H₂₀ClLiN₂O₈

分子量:

482.80

UNSPSC Code:

41116107

NACRES:

NA.24

EC Number:

200-659-6

MDL number:

MFCD29918103

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属性

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike^®/Snap-N-Shoot^®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant^®

drug control

Narcotic Licence Schedule B (Switzerland), kontrollierte Droge in Deutschland

concentration

100 μg/mL in methanol (as free carboxylate)

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

SMILES string

[Li+].CN1C(=O)C(O[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)C([O-])=O)N=C(c3ccccc3)c4cc(Cl)ccc14

InChI

1S/C22H21ClN2O8.Li/c1-25-13-8-7-11(23)9-12(13)14(10-5-3-2-4-6-10)24-19(20(25)29)33-22-17(28)15(26)16(27)18(32-22)21(30)31;/h2-9,15-19,22,26-28H,1H3,(H,30,31);/q;+1/p-1/t15-,16-,17+,18-,19?,22-;/m0./s1

InChI key

RQHXRNLYSZXQKI-NMJPLRNWSA-M

说明

General description

The major urinary and blood metabolite of temazepam, an intermediate-acting 3-hydroxy benzodiazepine prescribed for the short-term treatment of sleeplessness in patients with difficulties remaining asleep. This new Certified Reference Standard is suitable for a variety of LCMS and GCMS applications, including forensic and forensic toxicology analysis, urine drug testing, and hydrolysis controls.

Legal Information

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.

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pictograms

GHS02,GHS06,GHS08

signalword

Danger

hcodes

H225,H301 + H311 + H331,H370

pcodes

P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes,Central nervous system

存储类别

3 - Flammable liquids

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

法规信息

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实验方案

使用UHPLC/MS（TOF）检测不同酶水解条件处理的尿液中药物和代谢物

为了使用β-葡糖醛酸酶优化水解，必须对每种待分析的葡糖苷酸代谢物进行某些因素的评估，例如孵育时间、温度、水解pH、酶源和酶浓度。

UHPLC/MS for Drug Detection in Urine

Optimize β-glucuronidase hydrolysis for glucuronide metabolite analysis considering factors like time, temperature, pH, and enzyme concentration.

Determination of temazepam and temazepam glucuronide by reversed-phase high-performance liquid chromatography.

G W Kunsman et al.

Journal of chromatography, 568(2), 427-436 (1991-08-23)

A rapid and sensitive method for extracting temazepam from human serum and urine is presented. Free temazepam is extracted from plasma and urine samples using n-butyl chloride with nitrazepam as the internal standard. Temazepam glucuronide is analyzed as free temazepam

Commentary on: Dou C, Bournique J, Zinda M, Gnezda M, Nally A, Salamone S. Comparison of rates of hydrolysis of lorazepam-glucuronide, oxazepam-glucuronide and temazepam-glucuronide catalyzed by E. coli beta-glucuronidase using the on-line benzodiazepine screening immunoassay on the Roche/Hitachi 917 analyzer.

Carol L O'Neal et al.

Journal of forensic sciences, 47(2), 427-428 (2002-03-23)

全球贸易项目编号

货号	GTIN
T-050-1ML	04061837330155