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PHR1011

对羟基苯甲酸乙酯

Name: 对羟基苯甲酸乙酯
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

4-羟基苯甲酸乙酯, EP, 尼泊金乙酯

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关于此项目

线性分子式:

HOC₆H₄CO₂C₂H₅

化学文摘社编号:

120-47-8

分子量:

166.17

E Number:

E214

PubChem Substance ID:

329823042

eCl@ss:

39024522

UNSPSC Code:

41116107

NACRES:

NA.24

EC Number:

204-399-4

MDL number:

MFCD00002353

Beilstein/REAXYS Number:

1101972

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属性

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. E2425000, traceable to USP 1267000

API family

parabens

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

bp

297-298 °C (lit.)

mp

114-117 °C (lit.)

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CCOC(=O)c1ccc(O)cc1

InChI

1S/C9H10O3/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6,10H,2H2,1H3

InChI key

NUVBSKCKDOMJSU-UHFFFAOYSA-N

说明

General description

用于质量控制的制药二级标准品，为制药实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。

Application

对羟基苯甲酸乙酯可用作药物参考标准品，用于通过高效液相色谱（HPLC）测定药物制剂中的分析物。

这些二级标准品是经过检验的认证标准物质(CRM)。它们适用于多种分析应用，包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他标定应用。

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

在我们的NMR在线平台ChemisTwin®上可以找到本品对应的数字化标准物质。您可使用ChemisTwin®上的数字等效品鉴定您的样品并进行定量分析（使用数字化外标）。可查看该物质的NMR谱图，只需点击几次鼠标，就能进行在线样品比对。欢迎点击了解更多，开启免费试用之旅。

想要查看本品的分析证书示例，请在下框中输入LRAC3158。这只是一个示例证书，可能与您收到的批次不符。

该认证标准物质（CRM）根据ISO 17034 和 ISO/IEC 17025进行生产和认证。有关此CRM使用的所有信息均可在分析证书上找到。

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存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

分析证书(COA)

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Determination of combined p-hydroxy benzoic acid preservatives in a liquid pharmaceutical formulation by HPLC

Shabir GA.

Journal of Pharmaceutical and Biomedical Analysis, 34(1), 207-213 (2004)

Simultaneous analysis of antioxidants and preservatives in cosmetics by supercritical fluid extraction combined with liquid chromatography-mass spectrometry.

Maw-Rong Lee et al.

Journal of chromatography. A, 1120(1-2), 244-251 (2006-03-04)

This study evaluated supercritical fluid extraction (SFE) combined with liquid chromatography-mass spectrometry (LC-MS) to determine trace preservatives and antioxidants including methylparaben (MP), ethylparaben (EP), propylparaben (PP), butylparaben (BP), butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), alpha-tocopherol (alpha-t) and alpha-tocopherol acetate (alpha-ta)

The preservatives ethyl-, propyl- and butylparaben are oestrogenic in an in vivo fish assay.

K L Pedersen et al.

Pharmacology & toxicology, 86(3), 110-113 (2001-02-07)

The widely used phenolic preservatives ethylparaben, propylparaben, butylparaben and their common metabolite p-hydroxybenzoic acid were tested for their ability to evoke an oestrogenic response in vivo. Yolk protein induction in sexually immature rainbow trout was used as an oestrogen-specific endpoint

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全球贸易项目编号

货号	GTIN
PHR1011-10G	04061834413363
PHR1011-1G	04061835236862