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S2180000

舒林酸

Name: 舒林酸
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

别名:

(Z)-5-氟-2-甲基-1-[4-(甲亚硫酰苯基)亚甲基]-1H-茚-3-醋酸

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关于此项目

经验公式（希尔记法）:

C₂₀H₁₇FO₃S

化学文摘社编号:

38194-50-2

分子量:

356.41

NACRES:

NA.24

PubChem Substance ID:

329824512

UNSPSC Code:

41116107

MDL number:

MFCD00599589

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属性

grade

pharmaceutical primary standard

API family

sulindac

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CC1=C(CC(O)=O)c2cc(F)ccc2\C1=C/c3ccc(cc3)S(C)=O

InChI

1S/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-

InChI key

MLKXDPUZXIRXEP-MFOYZWKCSA-N

Gene Information

human ... PTGS1(5742), PTGS2(5743)

说明

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Sulindac EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

非甾体抗炎药；COX-1 的选择性抑制剂。

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301,H317,H334,H361

pcodes

P201 - P280 - P301 + P310 + P330 - P302 + P352

Hazard Classifications

Acute Tox. 3 Oral - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Adenomatous polyposis coli, protein kinases, protein tyrosine phosphatase: the effect of sulindac.

W R Waddell et al.

Journal of surgical oncology, 58(4), 252-256 (1995-04-01)

A putative explanation of the effect of sulindac on adenomatous colon and duodenal polyps from clinical observations and related in vitro experiments is presented. In cells with mutant APC genes, persistent high prostaglandin content of polyps leads to desensitization, downregulation

Sulindac: therapeutic implications of the prodrug/pharmacophore equilibrium.

D E Duggan

Drug metabolism reviews, 12(2), 325-337 (1981-01-01)

Sulindac is a prodrug which, following absorption, rapidly attains a metabolic equilibrium with its active pharmacophore, the sulfide metabolite. At the level of the whole body, the reversible interconversion sulindac in equilibrium sulfide, and the differing distributional and excretory properties

Single dose oral sulindac for acute postoperative pain in adults.

R Andrew Moore et al.

The Cochrane database of systematic reviews, (4)(4), CD007540-CD007540 (2009-10-13)

Sulindac is a non-steroidal anti-inflammatory drug (NSAID) licensed for use in rheumatic disease and other musculoskeletal disorders in the UK, and widely available in other countries worldwide. This review sought to evaluate the efficacy and safety of oral sulindac in

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全球贸易项目编号

货号	GTIN
S2180000	04061836917838
S2180000-2EA	04061835123117