assay
≥90% (HPLC)
form
lyophilized
composition
Peptide Content, ≥75%
storage condition
protect from light
storage temp.
−20°C
General description
淀粉样蛋白 β (Aβ) 1-42 是在阿尔茨海默病（AD）中出现的淀粉样斑块的主要成分。它具有交叉的β结构和平行的β片层
Application
大鼠淀粉样蛋白 β 1-42已被用作脑室内（ICV）注射/海马内灌注的淀粉样蛋白β （Aβ）寡聚糖，用于建立大鼠阿尔茨海默病（AD）模型。
Biochem/physiol Actions
与Aβ（1–40）相比，淀粉样蛋白 β 1-42更容易在体外形成淀粉样纤维丝。Aβ1-42注射液可导致脑功能失调，出现学习和记忆缺损。淀粉样蛋白β（Aβ）是指衍生自淀粉样前体蛋白的肽，其长度在37–43个氨基酸之间变化。Aβ（s）肽，其肽片段和突变片段用于研究广泛的代谢和调节功能，包括激酶的激活、胆固醇转运的调节、作为转录因子的功能和炎症的调节因子。Aβ（s）肽及其肽片段还用于研究氧化应激、金属结合和蛋白质交联机制，例如阿尔茨海默病和神经变性。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SCP0038-1MG | 04061837017469 |
| SCP0038-500UG | 04061837017476 |