10107921001

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Genome-wide analysis of thylakoid-bound ribosomes in maize reveals principles of cotranslational targeting to the thylakoid membrane.

Reimo Zoschke et al.

Proceedings of the National Academy of Sciences of the United States of America, 112(13), E1678-E1687 (2015-03-17)

Chloroplast genomes encode ∼ 37 proteins that integrate into the thylakoid membrane. The mechanisms that target these proteins to the membrane are largely unexplored. We used ribosome profiling to provide a comprehensive, high-resolution map of ribosome positions on chloroplast mRNAs

Combined micrococcal nuclease and exonuclease III digestion reveals precise positions of the nucleosome core/linker junctions: implications for high-resolution nucleosome mapping.

Tatiana Nikitina et al.

Journal of molecular biology, 425(11), 1946-1960 (2013-03-06)

Micrococcal nuclease (MNase) is extensively used in genome-wide mapping of nucleosomes but its preference for AT-rich DNA leads to errors in establishing precise positions of nucleosomes. Here, we show that the MNase digestion of nucleosomes assembled on a strong nucleosome

Molecular determinants of nucleosome retention at CpG-rich sequences in mouse spermatozoa.

Serap Erkek et al.

Nature structural & molecular biology, 20(7), 868-875 (2013-06-19)

In mammalian spermatozoa, most but not all of the genome is densely packaged by protamines. Here we reveal the molecular logic underlying the retention of nucleosomes in mouse spermatozoa, which contain only 1% residual histones. We observe high enrichment throughout

Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor.

Sarah O'Keefe et al.

Journal of cell science, 134(4) (2021-01-21)

In order to produce proteins essential for their propagation, many pathogenic human viruses, including SARS-CoV-2, the causative agent of COVID-19 respiratory disease, commandeer host biosynthetic machineries and mechanisms. Three major structural proteins, the spike, envelope and membrane proteins, are amongst

Ribonuclease selection for ribosome profiling.

Gerashchenko M V and Gladyshev V N

Nucleic Acids Research, 45(2), e6-e6 (2016)

Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor.

Sarah O'Keefe et al.

bioRxiv : the preprint server for biology (2020-12-04)

In order to produce proteins essential for their propagation, many pathogenic human viruses, including SARS-CoV-2 the causative agent of COVID-19 respiratory disease, commandeer host biosynthetic machineries and mechanisms. Three major structural proteins, the spike, envelope and membrane proteins, are amongst

Sequence specific cleavage of African green monkey ?-satellite DNA by micrococcal nuclease.

Horz W, et al.

Nucleic Acids Research, 11(13), 4275-4285 (1983)

Lethal (3) malignant brain tumor-like 2 (L3MBTL2) protein protects against kidney injury by inhibiting the DNA damage-p53-apoptosis pathway in renal tubular cells.

Huihui Huang et al.

Kidney international, 93(4), 855-870 (2017-12-26)

DNA damage contributes to renal tubular cell death during kidney injury, but how DNA damage in tubular cells is regulated is not fully understood. Lethal (3) malignant brain tumor-like 2 (L3MBTL2), a novel polycomb group protein, has been implicated in

Metabolically controlled histone H4K5 acylation/acetylation ratio drives BRD4 genomic distribution.

Mengqing Gao et al.

Cell reports, 36(4), 109460-109460 (2021-07-29)

In addition to acetylation, histones are modified by a series of competing longer-chain acylations. Most of these acylation marks are enriched and co-exist with acetylation on active gene regulatory elements. Their seemingly redundant functions hinder our understanding of histone acylations'

Organ-specific translation elongation rates measured by in vivo ribosome profiling.

Gerashchenko M V, et al.

bioRxiv, 279257 (2018)

Chl1 coordinates with H3K9 methyltransferase Clr4 to reduce the accumulation of RNA-DNA hybrids and maintain genome stability.

Deyun He et al.

iScience, 25(5), 104313-104313 (2022-05-24)

A genome-wide analysis in Schizosaccharomyces pombe indicated that double-deletion mutants of Chl1 and histone H3K9 methyltransferase complex factors are synthetically sick. Here, we show that loss of Chl1 increases the accumulation of RNA-DNA hybrids at pericentromeric dg and dh repeats

Histone H3 lysine 4 trimethylation in sperm is transmitted to the embryo and associated with diet-induced phenotypes in the offspring.

Ariane Lismer et al.

Developmental cell, 56(5), 671-686 (2021-02-18)

A father's lifestyle impacts offspring health; yet, the underlying molecular mechanisms remain elusive. We hypothesized that a diet that changes methyl donor availability will alter the sperm and embryo epigenomes to impact embryonic gene expression and development. Here, we demonstrate

High sequence specificity of micrococcal nuclease.

Dingwall C, et al.

Nucleic Acids Research, 9(12), 2659-2674 (1981)

Monitoring mammalian mitochondrial translation with MitoRiboSeq.

Sophia Hsin-Jung Li et al.

Nature protocols, 16(6), 2802-2825 (2021-05-07)

Several essential components of the electron transport chain, the major producer of ATP in mammalian cells, are encoded in the mitochondrial genome. These 13 proteins are translated within mitochondria by 'mitoribosomes'. Defective mitochondrial translation underlies multiple inborn errors of metabolism

Co-translational biogenesis of lipid droplet integral membrane proteins.

Pawel Leznicki et al.

Journal of cell science, 135(5) (2021-09-25)

Membrane proteins destined for lipid droplets (LDs), a major intracellular storage site for neutral lipids, are inserted into the endoplasmic reticulum (ER) and then trafficked to LDs where they reside in a hairpin loop conformation. Here, we show that LD

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