11376497001

应用筛选条件

关键词:'11376497001'

显示 1-12 共 12 条结果关于 "11376497001" 范围论文

Disease-specific phenotypes in iPSC-derived neural stem cells with POLG mutations.

Kristina Xiao Liang et al.

EMBO molecular medicine, 12(10), e12146-e12146 (2020-08-26)

Mutations in POLG disrupt mtDNA replication and cause devastating diseases often with neurological phenotypes. Defining disease mechanisms has been hampered by limited access to human tissues, particularly neurons. Using patient cells carrying POLG mutations, we generated iPSCs and then neural

Subetta increases phosphorylation of insulin receptor β-subunit alone and in the presence of insulin.

E A Gorbunov et al.

Nutrition & diabetes, 5, e169-e169 (2015-07-07)

It has been previously shown that Subetta (a drug containing released-active forms of antibodies to the insulin receptor β-subunit and antibodies to endothelial nitric oxide synthase) stimulated insulin-induced adiponectin production by mature human adipocytes in the absence of insulin. Therefore

Transcriptional effects of transfection: the potential for misinterpretation of gene expression data generated from transiently transfected cells.

Linda Jacobsen et al.

BioTechniques, 47(1), 617-624 (2009-07-15)

Transfection is used to introduce a gene of interest into a cell. To interpret the downstream results, understanding which effects are the true biological responses to the gene and which, if any, are off-target effects can be difficult. In order

The site of breast cancer metastases dictates their clonal composition and reversible transcriptomic profile.

Jean Berthelet et al.

Science advances, 7(28) (2021-07-09)

Intratumoral heterogeneity is a driver of breast cancer progression, but the nature of the clonal interactive network involved in this process remains unclear. Here, we optimized the use of optical barcoding to visualize and characterize 31 cancer subclones in vivo.

Insulin differentially modulates GABA signalling in hippocampal neurons and, in an age-dependent manner, normalizes GABA-activated currents in the tg-APPSwe mouse model of Alzheimer's disease.

Hayma Hammoud et al.

Acta physiologica (Oxford, England), 232(2), e13623-e13623 (2021-02-10)

We examined if tonic γ-aminobutyric acid (GABA)-activated currents in primary hippocampal neurons were modulated by insulin in wild-type and tg-APPSwe mice, an Alzheimer's disease (AD) model. GABA-activated currents were recorded in dentate gyrus (DG) granule cells and CA3 pyramidal neurons

Distinct skeletal stem cell types orchestrate long bone skeletogenesis.

Thomas H Ambrosi et al.

eLife, 10 (2021-07-20)

Skeletal stem and progenitor cell populations are crucial for bone physiology. Characterization of these cell types remains restricted to heterogenous bulk populations with limited information on whether they are unique or overlap with previously characterized cell types. Here we show

Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards.

Renata M Martin et al.

Nature communications, 11(1), 2713-2713 (2020-06-03)

Despite their rapidly-expanding therapeutic potential, human pluripotent stem cell (hPSC)-derived cell therapies continue to have serious safety risks. Transplantation of hPSC-derived cell populations into preclinical models has generated teratomas (tumors arising from undifferentiated hPSCs), unwanted tissues, and other types of

Exercise Training Promotes Sex-Specific Adaptations in Mouse Inguinal White Adipose Tissue.

Pasquale Nigro et al.

Diabetes, 70(6), 1250-1264 (2021-02-11)

Recent studies demonstrate that adaptations to white adipose tissue (WAT) are important components of the beneficial effects of exercise training on metabolic health. Exercise training favorably alters the phenotype of subcutaneous inguinal WAT (iWAT) in male mice, including decreasing fat

The insulin signaling system.

M F White et al.

The Journal of biological chemistry, 269(1), 1-4 (1994-01-07)

Pannexin-1 mediated ATP release in adipocytes is sensitive to glucose and insulin and modulates lipolysis and macrophage migration.

Marco Tozzi et al.

Acta physiologica (Oxford, England), 228(2), e13360-e13360 (2019-08-11)

Extracellular ATP signalling is involved in many physiological and pathophysiological processes in several tissues, including adipose tissue. Adipocytes have crucial functions in lipid and glucose metabolism and they express purinergic receptors. However, the sources of extracellular ATP in adipose tissue

An siRNA-based method for efficient silencing of gene expression in mature brown adipocytes.

Marie S Isidor et al.

Adipocyte, 5(2), 175-185 (2016-07-08)

Brown adipose tissue is a promising therapeutic target for opposing obesity, glucose intolerance and insulin resistance. The ability to modulate gene expression in mature brown adipocytes is important to understand brown adipocyte function and delineate novel regulatory mechanisms of non-shivering

Insulin Crystals Grown in Short-Peptide Supramolecular Hydrogels Show Enhanced Thermal Stability and Slower Release Profile.

Rafael Contreras-Montoya et al.

ACS applied materials & interfaces, 13(10), 11672-11682 (2021-03-05)

Protein therapeutics have a major role in medicine in that they are used to treat diverse pathologies. Their three-dimensional structures not only offer higher specificity and lower toxicity than small organic compounds but also make them less stable, limiting their

1/1