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Tom Kamperman et al.
Nature communications, 10(1), 4347-4347 (2019-09-27)
Spatiotemporal control over engineered tissues is highly desirable for various biomedical applications as it emulates the dynamic behavior of natural tissues. Current spatiotemporal biomaterial functionalization approaches are based on cytotoxic, technically challenging, or non-scalable chemistries, which has hampered their widespread
Munish Kumar et al.
Biophysical chemistry, 237, 38-46 (2018-04-16)
Gold nanoparticles (AuNPs) functionalized with different biomolecules find extensive application in therapy, clinical diagnosis and biomedical imaging. Herein, two derivatives of TAT peptide with sequences YGRKKRRQRRR and YGRKKRRQRRR-(β-ala)3-Cys-amide were conjugated with tannic acid capped gold nanoparticles which acted as a
Hyo-Eon Jin et al.
Nano letters, 15(11), 7697-7703 (2015-10-13)
We report a highly selective and sensitive biosensor for the detection of an environmentally toxic molecule, decabrominated diphenyl ether (DBDE), one of the most common congeners of the polybrominated frame retardants (polybrominated diphenyl ether (PBDE)), using newly discovered DBDE peptide
Yang Li et al.
Macromolecular bioscience, 15(1), 52-62 (2014-12-06)
To address the downside of conventional photo-patterning which can alter the chemical composition of protein scaffolds, we developed a non-covalent photo-patterning strategy for gelatin (denatured collagen) hydrogels that utilizes UV activated triple helical hybridization of caged collagen mimetic peptide (caged
Whitney C Blocher McTigue et al.
Soft matter, 15(15), 3089-3103 (2019-03-28)
We investigated the encapsulation of the model proteins bovine serum albumin (BSA), human hemoglobin (Hb), and hen egg white lysozyme (HEWL) into two-polymer complex coacervates as a function of polymer and solution conditions. Electrostatic parameters such as pH, protein net
Pingping Li et al.
ACS applied materials & interfaces, 11(14), 13624-13631 (2019-03-20)
Combining polymeric materials and conductive one-dimensional metal nanostructures is able to achieve enhanced chemical and electrical properties, but the control over their morphology and spatial arrangement remains a big challenge. Herein, by replacing benzenedicarboxylate (BDC) in ZnBDC nanoplates with oleylamine
Maria P Ikonomopoulou et al.
Scientific reports, 8(1), 11519-11519 (2018-08-03)
Consistent with their diverse pharmacology, peptides derived from venomous animals have been developed as drugs to treat disorders as diverse as hypertension, diabetes and chronic pain. Melanoma has a poor prognosis due in part to its metastatic capacity, warranting further
Yan Wang et al.
ACS nano, 12(10), 9742-9749 (2018-09-19)
Stretchable electronics may enable electronic components to be part of our organs-ideal for future wearable/implantable biodiagnostic systems. One of key challenges is failure of the soft/rigid material interface due to mismatching Young's moduli, which limits stretchability and durability of current
Katlyn A Fleming et al.
ACS chemical neuroscience, 9(5), 1141-1151 (2018-01-25)
The melanocortin system has five receptors, and antagonists of the central melanocortin receptors (MC3R, MC4R) are postulated to be viable therapeutics for disorders of negative energy balance such as anorexia, cachexia, and failure to thrive. Agouti-related protein (AGRP) is an
Xavier Vila-Farrés et al.
Scientific reports, 7(1), 14683-14683 (2017-11-02)
Preventing the adhesion of pathogens to host cells provides an innovative approach to tackling multidrug-resistant bacteria. In this regard, the identification of outer membrane protein A (OmpA) as a key bacterial virulence factor has been a major breakthrough. The use
Carmine Pasquale Cerrato et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(11), 4589-4599 (2015-07-22)
Cell-penetrating peptides (CPPs) are short, nontoxic peptides with cationic and/or amphipathic properties able to cross the cellular membrane. CPPs are used for the delivery of a wide variety of cargoes, such as proteins, oligonucleotides, and therapeutic molecules. The aim of
Dongwoo Lee et al.
Journal of biomedical materials research. Part A, 107(11), 2392-2402 (2019-06-09)
Peptide and proteins are recognized as highly selective and therapeutically active biomaterials, as well as relatively safe in clinical application. A calcium phospholipid-binding protein, copine 7 (CPNE7), has been recently identified to induce hard tissue regeneration, including bone and dentin
Sören Reinhard et al.
ChemMedChem, 12(17), 1464-1470 (2017-07-18)
Cationic lipo-oligomers containing unsaturated oleic acid are potent siRNA carriers based on electrostatic and hydrophobic lipo-polyplex formation and endosomal membrane destabilization. Lipo-oligomers can be produced by solid-phase-supported synthesis in sequence-defined form. However, the trifluoroacetic acid (TFA)-mediated removal of acid-labile protecting
Lidia Ciccone et al.
Scientific reports, 8(1), 13744-13744 (2018-09-15)
Transthyretin (TTR), a homotetrameric protein that transports thyroxine and retinol both in plasma and in cerebrospinal (CSF) fluid provides a natural protective response against Alzheimer's disease (AD), modulates amyloid-β (Aβ) deposition by direct interaction and co-localizes with Aβ in plaques.
Kyle M Koss et al.
Materials (Basel, Switzerland), 11(9) (2018-08-29)
(Arginine-alanine-aspartic acid-alanine)₄ ((RADA)₄) nanoscaffolds are excellent candidates for use as peptide delivery vehicles: they are relatively easy to synthesize with custom bio-functionality, and assemble in situ to allow a focal point of release. This enables (RADA)₄ to be utilized in
Yong An et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 216, 319-327 (2019-03-26)
In this study, we report a sequential and reversibility fluorescent probe (DP5) based on pentapeptide conjugated with dansyl groups using the solid phase peptide synthesis (SPPS) technology. DP5 showed immediate "turn off" response toward Cu2+ ions at an excitation wavelength
Devi Wahyuningtyas et al.
Chembiochem : a European journal of chemical biology, 20(16), 2133-2140 (2019-06-06)
Huntington's disease (HD) is classified as a protein-misfolding disease correlated with the mutant Huntingtin (mHtt) protein with abnormally expanded polyglutamine (polyQ) domains. Because no effective drugs have yet been reported, attempts to develop better therapy to delay the age of
Karla A G Gusmão et al.
The journal of venomous animals and toxins including tropical diseases, 23, 4-4 (2017-01-25)
The availability of antimicrobial peptides from several different natural sources has opened an avenue for the discovery of new biologically active molecules. To the best of our knowledge, only two peptides isolated from the frog Three peptide primary structures were
Petra Kos et al.
Journal of pharmaceutical sciences, 104(2), 464-475 (2014-10-01)
For active cell targeting, viruses frequently capitalize on dual-receptor binding. With the intention to mimic this natural process, a dual peptide-based approach for targeting cancer cells was evaluated. For this purpose, sequence-defined pDNA binding oligo (ethane amino) amides containing a
Nanoallergen platform for detection of platin drug allergies.
Peter E Deak et al.
The Journal of allergy and clinical immunology, 143(5), 1957-1960 (2019-01-27)
Deborah L Heyl et al.
Protein and peptide letters, 26(7), 502-511 (2019-04-06)
Amyloid fibrils in Alzheimer's disease are composed of amyloid-β (Aβ) peptides of variant lengths. Humanin (HN), a 24 amino acid residue neuroprotective peptide, is known to interact with the predominant Aβ isoform in the brain, Aβ (1-40). Here, we constructed
Alice P McCloskey et al.
Journal of peptide science : an official publication of the European Peptide Society, 23(2), 131-140 (2017-01-10)
Biomaterial-related infections have a significant impact on society and are a major contributor to the growing threat of antimicrobial resistance. Current licensed antibiotic classes struggle to breakdown or penetrate the exopolysaccharide biofilm barrier, resulting in sub-therapeutic concentrations of antibiotic at
Isis C Prado et al.
Biosensors & bioelectronics, 100, 115-121 (2017-09-09)
Spotted fever is a rare acute and multisystemic febrile infectious disease with a mortality rate of ≥50% without adequate antibiotic treatment, and in diagnosed and treated cases, of approximately 2.5%. Currently, the applied test to diagnose this disease is the
Peter E Deak et al.
Scientific reports, 7(1), 3981-3981 (2017-06-24)
Current methods for detection and diagnosis of allergies do not provide epitope specific immunogenic information and hence lack critical information that could aid in the prediction of clinical responses. To address this issue, we developed a nanoparticle based platform, called
Juan M Gurevich Messina et al.
Journal of peptide science : an official publication of the European Peptide Society, 24(11), e3128-e3128 (2018-10-06)
Peptide KVPLITVSKAK was selected to design a synthetic ligand for affinity chromatography purification of recombinant human follicle stimulating hormone (rhFSH), based on the interaction of the hormone with the exoloop 3 of its receptor. The peptide was acetylated to improve
E Gibula-Tarlowska et al.
Behavioural brain research, 372, 112043-112043 (2019-06-22)
Kissorphin (KSO) is a new peptide derived from kisspeptin-10. Previous study has indicated that this peptide displays neuropeptide FF (NPFF)-like anti-opioid activity. Herein, we examined the influence of KSO (1; 3, and 10 nmol, intravenously [i.v.]), on the rewarding action of
Tong-Yuan Lin et al.
Bioorganic & medicinal chemistry, 26(12), 3429-3437 (2018-05-29)
Polo-like kinase 1 (Plk1) is an anti-cancer target due to its critical role in mitotic progression. A growing body of evidence has documented that Peptide-Plk1 inhibitors showed high Plk1 binding affinity. However, phosphopeptides-Plk1 inhibitors showed poor cell membranes permeability, which
Ana Krhac Levacic et al.
Human gene therapy, 28(10), 862-874 (2017-08-23)
Due to its minimal size and lack of bacterial backbone sequences, minicircle (MC) DNA presents a promising alternative to plasmid DNA (pDNA) for non-viral gene delivery in terms of biosafety and improved gene transfer. Here, luciferase pDNA (pCMV-luc) and analogous
Oscar B Torres et al.
Analytical and bioanalytical chemistry, 406(24), 5927-5937 (2014-08-03)
A potential new treatment for drug addiction is immunization with vaccines that induce antibodies that can abrogate the addictive effects of the drug of abuse. One of the challenges in the development of a vaccine against drugs of abuse is
Kanicha Sa-ei et al.
Organic letters, 8(20), 4441-4443 (2006-09-22)
The catalytic, diastereoselective coupling of alpha-silyloxy aldehydes and alkynylsilanes catalyzed by a nickel(0) N-heterocyclic carbene complex provides an effective entry to anti-1,2-diols. The scope of couplings and extent of diastereoselection are excellent across a range of substrates.
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