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Kha Tram et al.
PloS one, 10(5), e0126402-e0126402 (2015-05-07)
Many DNAzymes have been isolated from synthetic DNA pools to cleave natural RNA (D-RNA) substrates and some have been utilized for the design of aptazyme biosensors for bioanalytical applications. Even though these biosensors perform well in simple sample matrices, they
Anita Leocadio Freitas-Mesquita et al.
Experimental parasitology, 137, 8-13 (2013-12-10)
Several ecto-enzymatic activities have been described in the plasma membrane of the protozoan Leishmania amazonensis, which is the major etiological agent of diffuse cutaneous leishmaniasis in South America. These enzymes, including ecto-phosphatases, contribute to the survival of the parasite by
C Escobedo-Fregoso et al.
Transboundary and emerging diseases, 62(2), 137-147 (2013-04-24)
Prevalence of the protozoan Perkinsus spp. in the gills of the pleasure oyster Crassostrea corteziensis from two estuaries in Nayarit, Mexico, was measured. The protozoan was identified by PCR amplification of the internal transcribed spacer (ITS) region of the rDNA
Prashant Kumar Singh et al.
Journal of proteomics, 127(Pt A), 134-146 (2015-05-30)
Present study demonstrates interspecies variation in proteome and survival strategy of three Anabaena species i.e., Anabaena L31, Anabaena sp. PCC 7120 and Anabaena doliolum subjected to respective LC50 doses of Cd at 0, 1, 3, 5 and 7day intervals. The
Katie L Barott et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 309(3), R235-R246 (2015-06-13)
Ion transport is fundamental for multiple physiological processes, including but not limited to pH regulation, calcification, and photosynthesis. Here, we investigated ion-transporting processes in tissues from the corals Acropora yongei and Stylophora pistillata, representatives of the complex and robust clades
Dora A Li et al.
Molecular genetics and genomics : MGG, 290(6), 2313-2324 (2015-07-03)
Carotenoids (especially lutein) are known to be the pigment source for flour b* colour in bread wheat. Flour b* colour variation is controlled by a quantitative trait locus (QTL) on wheat chromosome 7AL and one gene from the carotenoid pathway
G Cipriani et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 27(7), 997-1009 (2015-05-02)
Otilonium bromide (OB) is used as a spasmolytic drug in the treatment of the functional bowel disorder irritable bowel syndrome. Although its acute effects on colonic relaxation are well-characterized, little is known about the effects of chronic administration of OB
Xiaolu Duan et al.
Journal of cellular physiology, 230(10), 2371-2381 (2015-03-11)
β-Arrestin2 has been identified to act as a corepressor of androgen receptor (AR) signaling by binding to AR and serving as a scaffold to affect the activity and expression of AR in androgen-dependent prostate cancer cells; however, little is known
Subham Mookerjee et al.
PloS one, 10(9), e0137338-e0137338 (2015-09-05)
Diarrheal disease remains an unsolved problem in developing countries. The emergence of new etiological agents (non-cholera vibrios) is a major cause of concern for health planners. We attempted to unveil the seasonal dynamics of entero-pathogenic Vibrios in Gangetic riverine-estuarine ecosystem.
Ana L Morgado et al.
Molecular neurobiology, 51(3), 1168-1183 (2014-06-29)
We have previously demonstrated the involvement of specific apoptosis-associated microRNAs (miRNAs), including miR-34a, in mouse neural stem cell (NSC) differentiation. In addition, a growing body of evidence points to a critical role for autophagy during neuronal differentiation, as a response-survival
Steven Lacy et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(8), 1190-1207 (2015-05-28)
Metabolism and excretion of cabozantinib, an oral inhibitor of receptor tyrosine kinases, was studied in 8 healthy male volunteers after a single oral dose of 175 mg cabozantinib l-malate containing (14)C-cabozantinib (100 µCi/subject). Total mean radioactivity recovery within 48 days
Jose M Sánchez-Robles et al.
Molecular ecology, 23(24), 6165-6178 (2014-10-31)
Plant architecture is crucial to pollination and mating in wind-pollinated species. We investigated the effect of crown architecture on pollen dispersal, mating system and offspring quality, combining phenotypic and genotypic analyses in a low-density population of the endangered species Abies
Jung Min Hwang et al.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 126(7), 1348-1353 (2014-12-03)
To investigate whether there is a relation between the plasticity induced by different intensities of facilitatory rTMS with different intensities and brain-derived neurotrophic factor (BDNF) genotype. Forty healthy volunteers (14 men, mean age 27.3years) were enrolled. All participants received three
Avanti Gokhale et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(19), 7643-7653 (2015-05-15)
Dysbindin is a schizophrenia susceptibility factor and subunit of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) required for lysosome-related organelle biogenesis, and in neurons, synaptic vesicle assembly, neurotransmission, and plasticity. Protein networks, or interactomes, downstream of dysbindin/BLOC-1 remain partially
J W Chung et al.
Journal of applied microbiology, 119(3), 876-884 (2015-06-03)
To determine the pathogenic virus removal performance of an adsorbent produced from hydrothermal carbonization of sewage sludge. The removal of human pathogenic rotavirus and adenovirus was investigated with columns of 10 cm saturated sand with and without amendments of 1·5%
Jürgen Behr et al.
Food microbiology, 51, 130-138 (2015-07-19)
The tolerance to hop compounds, which is mainly associated with inhibition of bacterial growth in beer, is a multi-factorial trait. Any approaches to predict the physiological differences between beer-spoiling and non-spoiling strains on the basis of a single marker gene
R Jason Pitts et al.
PloS one, 9(10), e111858-e111858 (2014-11-02)
The principal Afrotropical malaria vector mosquito, Anopheles gambiae remains a significant threat to human health. In this anthropophagic species, females detect and respond to a range of human-derived volatile kairomones such as ammonia, lactic acid, and other carboxylic acids in
Emilia Joanna Orzechowska et al.
BMC cancer, 14, 771-771 (2014-10-19)
Low cellular level of BID is critical for viability of numerous cancer cells. Sensitization of cells to anticancer agents by BID overexpression from adenovirus or pcDNA vectors is a proposed strategy for cancer therapy; however it does not provide any
Shoaib Ashraf et al.
International journal for parasitology, 45(9-10), 647-654 (2015-05-10)
Haemonchus contortus is a nematode of livestock that can cause severe disease and mortality. Ivermectin, an anti-parasitic drug that targets glutamate-gated chloride channels, is widely used in humans, livestock, companion animals and agriculture. Although an association between genetic changes to
Lisheng Ni et al.
Genes & development, 29(13), 1416-1431 (2015-06-26)
The Mst-Lats kinase cascade is central to the Hippo tumor-suppressive pathway that controls organ size and tissue homeostasis. The adaptor protein Mob1 promotes Lats activation by Mst, but the mechanism remains unknown. Here, we show that human Mob1 binds to
Danzhen Pan et al.
PloS one, 10(5), e0125658-e0125658 (2015-05-06)
Hydrodynamic injection (HI) with a replication competent hepatitis B virus (HBV) genome may lead to transient or prolonged HBV replication in mice. However, the prolonged HBV persistence after HI depends on the specific backbone of the vector carrying HBV genome
Reply: To PMID 23474429.
Christine Metz et al.
American journal of obstetrics and gynecology, 209(5), 498-499 (2013-06-19)
Toshikazu Yamaoka et al.
Journal of pharmacological and toxicological methods, 76, 83-95 (2015-09-01)
Glutathione (GSH) trapping assays are widely used to predict the post-marketing risk for idiosyncratic drug reactions (IDRs) in the pharmaceutical industry. Although several GSH derivatives have been introduced as trapping reagents for reactive intermediates, more sensitive and selective reagents are
Marcela Cataldi et al.
Virology, 485, 340-354 (2015-09-04)
Vesicular stomatitis virus (VSV) is an effective oncolytic virus against most human pancreatic ductal adenocarcinoma (PDAC) cell lines. However, some PDAC cell lines are highly resistant to oncolytic VSV-ΔM51 infection. To better understand the mechanism of resistance, we tested a
M P Smal et al.
Experimental oncology, 36(4), 246-251 (2014-12-30)
The aim of this study was to determine the frequencies of FGFR3 and TP53 mutations in a prospective cohort of 150 bladder cancer patients and to assess the relationship between their mutational status and clinicopathological variables. The FGFR3 and TP53
Enlin Song et al.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 25(3), 345-355 (2015-02-20)
The aim of this study was to investigate the association of astrocyte elevated gene-1 (AEG-1) with epithelial-mesenchymal transition of cervical squamous cell carcinoma (CSCC) and the underlying mechanisms. The expression of proteins was determined by immunohistochemistry in tissues. Overexpression and
Katherine T Bliss et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(9), 3987-3995 (2014-06-04)
Tropomodulin1 (Tmod1) is an actin-capping protein that plays an important role in actin filament pointed-end dynamics and length in striated muscle. No mechanisms have been identified to explain how Tmod1's functional properties are regulated. The purpose of this investigation was
Anne-Sophie Bergot et al.
PLoS pathogens, 10(10), e1004466-e1004466 (2014-10-24)
Human Papillomavirus (HPV) 16 E7 protein promotes the transformation of HPV infected epithelium to malignancy. Here, we use a murine model in which the E7 protein of HPV16 is expressed as a transgene in epithelium to show that mast cells
Sarah A Andres et al.
Breast cancer research and treatment, 152(3), 545-556 (2015-07-24)
In contrast to studies focused on cigarette smoking and risk of breast cancer occurrence, this study explored the influence of smoking on breast cancer recurrence and progression. The goal was to evaluate the interaction between smoking history and gene expression
V Hönig et al.
Ticks and tick-borne diseases, 6(5), 559-567 (2015-05-16)
Spatial distribution of Ixodes ricinus tick host-seeking activity, as well as prevalence of Borrelia burgdorferi sensu lato and tick-borne encephalitis virus (TBEV) were studied in the TBE endemic area of South Bohemia (Czech Republic). High variability in tick abundance detected
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