655104

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Interaction analysis of aspirin with selective amino acids.

Ghulam Murtaza et al.

Acta poloniae pharmaceutica, 71(1), 139-143 (2014-05-02)

This study was conducted to assess the compatibility of aspirin with selective amino acids by studying the effect of amino acids on the solubility of aspirin, so that the attention could be paid towards the use of proteinous foods along

Preparation of linear maltodextrins using a hyperthermophilic amylopullulanase with cyclodextrin- and starch-hydrolysing activities.

Xiaolei Li et al.

Carbohydrate polymers, 119, 134-141 (2015-01-08)

A novel method for the preparation of linear maltodextrins from cyclodextrins and starch was proposed. To accomplish this process, an amylopullulanase from hyperthermophilic archaeon Caldivirga maquilingensis (CMApu) was characterized and used. CMApu with an estimated molecular mass of 62.7 kDa

Qualitative and quantitative analysis of branches in dextran using high-performance anion exchange chromatography coupled to quadrupole time-of-flight mass spectrometry.

Lin Yi et al.

Journal of chromatography. A, 1423, 79-85 (2015-11-05)

Dextran, a family of natural polysaccharides, consists of an α (1→6) linked-glucose main (backbone) chain having a number of branches. The determination of the types and the quantities of branches in dextran is important in understanding its various biological roles.

Synthesis of Small Au-Ag Core-Shell Cubes, Cuboctahedra, and Octahedra with Size Tunability and Their Optical and Photothermal Properties.

Chieh Chiang et al.

Small (Weinheim an der Bergstrasse, Germany), 11(45), 6018-6025 (2015-10-10)

Aqueous phase synthesis of small Au-Ag core-shell nanocubes, cuboctahedra, and octahedra is achieved through the deposition of Ag shells on small octahedral Au cores. These nanocrystals show efficient photothermal activity and can assemble into supercrystals.

Tumor-targeted responsive nanoparticle-based systems for magnetic resonance imaging and therapy.

Ronak Savla et al.

Pharmaceutical research, 31(12), 3487-3502 (2014-06-13)

Design and synthesis of a tumor responsive nanoparticle-based system for imaging and treatment of various cancers. Manganese oxide nanoparticles (Mn3O4 NPs) were synthesized and modified with LHRH targeting peptide or anti-melanoma antibodies (cancer targeting moieties) and a MMP2 cleavable peptide

Phytase activity in lichens.

Niall F Higgins et al.

The New phytologist, 208(2), 544-554 (2015-05-13)

Phytase activity was investigated in 13 lichen species using a novel assay method. The work tested the hypothesis that phytase is a component of the suite of surface-bound lichen enzymes that hydrolyse simple organic forms of phosphorus (P) and nitrogen

Effects of heating on composition, degree of darkness, and stacking nanostructure of soil humic acids.

Naoya Katsumi et al.

The Science of the total environment, 541, 23-32 (2015-09-24)

Wildfires and prescribed burning can affect both the quality and the quantity of organic matter in soils. In this study, we investigated qualitative and quantitative changes of soil humic substances in two different soils (an Entisol from a paddy field

Development and validation of a high-performance liquid chromatography-fluorescence detection method for the accurate quantification of colistin in human plasma.

Divyabharathi Chepyala et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 980, 48-54 (2015-01-16)

Recently, colistin has become one of the most important drugs for treating infections caused by multidrug-resistant Gram-negative bacteria. Therapeutic drug monitoring is recommended to ensure the safety and efficacy of colistin and to improve clinical outcomes. This study developed an

Identification of new synthetic PDE-5 inhibitors analogues found as minor components in a dietary supplement.

Nicholas Schramek et al.

Journal of pharmaceutical and biomedical analysis, 96, 45-53 (2014-04-15)

A dietary supplement sold in erotic shops was analysed. It contains dithiodesmethylcarbodenafil as the major component, which was already reported as an adulterant in dietary supplements. Additionally three more compounds were found and their structures were elucidated after isolation using

High-throughput screening with nanoimprinting 3D culture for efficient drug development by mimicking the tumor environment.

Yukie Yoshii et al.

Biomaterials, 51, 278-289 (2015-03-17)

Anti-cancer drug development typically utilizes high-throughput screening with two-dimensional (2D) cell culture. However, 2D culture induces cellular characteristics different from tumors in vivo, resulting in inefficient drug development. Here, we report an innovative high-throughput screening system using nanoimprinting 3D culture

Polymer hydrogel functionalized with biodegradable nanoparticles as composite system for controlled drug delivery.

Filippo Rossi et al.

Nanotechnology, 26(1), 015602-015602 (2014-12-10)

The possibility to direct pharmacological treatments targeting specific cell lines using polymer nanoparticles is one of the main novelties and perspectives in nanomedicine. However, sometimes, the ability to maintain NPs localized at the site of the injection that work as

Sensitive and selective determination of hydroxychloroquine in the presence of uric acid using a new nanostructure self-assembled monolayer modified electrode: optimization by multivariate data analysis.

Asma Khoobi et al.

The Analyst, 139(16), 4064-4072 (2014-06-24)

A highly sensitive electrochemical nanosensor was developed using covalent modification of a glassy carbon electrode (GCE) by self-assembly of a novel Schiff base. Scanning electron microscopy (SEM) and electrochemical techniques were used to investigate the immobilization of the self-assembled monolayer

A new three dimensional biomimetic hydrogel to deliver factors secreted by human mesenchymal stem cells in spinal cord injury.

Ilaria Caron et al.

Biomaterials, 75, 135-147 (2015-10-27)

Stem cell therapy with human mesenchymal stem cells (hMSCs) represents a promising strategy in spinal cord injury (SCI). However, both systemic and parenchymal hMSCs administrations show significant drawbacks as a limited number and viability of stem cells in situ. Biomaterials

Graphene oxide nanosheets at the water-organic solvent interface: utilization in one-pot adsorption and reactive extraction of dye molecules.

Ponchami Sharma et al.

Chemphyschem : a European journal of chemical physics and physical chemistry, 15(18), 4019-4025 (2014-10-11)

Graphene oxide (GO) is amphiphilic in nature, due to its structure, which consists of hydrophilic oxygen-containing functional groups and a hydrophobic basal plane of polyaromatic benzene rings. Due to this amphiphilicity, GO can create stable bubbles at water-organic solvent interfaces.

Chronic fluoxetine treatment increases NO bioavailability and calcium-sensitive potassium channels activation in rat mesenteric resistance arteries.

Camila A Pereira et al.

European journal of pharmacology, 765, 375-383 (2015-09-13)

Fluoxetine, a selective serotonin reuptake inhibitor (SSRI), has effects beyond its antidepressant properties, altering, e.g., mechanisms involved in blood pressure and vasomotor tone control. Although many studies have addressed the acute impact of fluoxetine on the cardiovascular system, there is

Identification of Coccoidal Bacteria in Traditional Fermented Milk Products from Mongolia, and the Fermentation Properties of the Predominant Species, Streptococcus thermophilus.

Yan Ren et al.

Korean journal for food science of animal resources, 35(5), 683-691 (2016-01-14)

The objective of this study was to identify the coccoidal bacteria present in 188 samples of fermented yaks', mares' and cows' milk products collected from 12 different regions in Mongolia. Furthermore, we evaluated the fermentation properties of ten selected isolates

Assessment of in vitro cyto/genotoxicity of sequentially treated electroplating effluent on the human hepatocarcinoma HuH-7 cell line.

Umesh Chandra Naik et al.

Mutation research. Genetic toxicology and environmental mutagenesis, 762, 9-16 (2014-02-15)

The present study compares in vitro toxicity of electroplating effluent after the batch treatment process with that obtained after the sequential treatment process. Activated charcoal prepared from sugarcane bagasse through chemical carbonization, and tolerant indigenous bacteria, Bacillus sp. strain IST105

Strength determination of brittle materials as curved monolithic structures.

P Hooi et al.

Journal of dental research, 93(4), 412-416 (2014-02-12)

The dental literature is replete with "crunch the crown" monotonic load-to-failure studies of all-ceramic materials despite fracture behavior being dominated by the indenter contact surface. Load-to-failure data provide no information on stress patterns, and comparisons among studies are impossible owing

Solid-State Conversion Chemistry of Multicomponent Nanocrystals Cast in a Hollow Silica Nanosphere: Morphology-Controlled Syntheses of Hybrid Nanocrystals.

Yeon Jun Kim et al.

ACS nano, 9(11), 10719-10728 (2015-10-31)

During thermal transformation of multicomponent nanocrystals in a silica nanosphere, FeAuPd alloy nanocrystals migrate outward and thereby leave a cavity in the silica matrix. Oxidation then converts these nanocrystals back into phase-segregated hybrid nanocrystals, AuPd@Fe3O4, with various morphologies. The FeAuPd-to-AuPd@Fe3O4

A custom tailored model to investigate skin penetration in porcine skin and its comparison with human skin.

Michael E Herbig et al.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 95(Pt A), 99-109 (2015-04-11)

Reliable models for the determination of skin penetration and permeation are important for the development of new drugs and formulations. The intention of our study was to develop a skin penetration model which (1) is viable and well supplied with

The Essential Role of Cholesterol Metabolism in the Intracellular Survival of Mycobacterium leprae Is Not Coupled to Central Carbon Metabolism and Energy Production.

Maria Angela M Marques et al.

Journal of bacteriology, 197(23), 3698-3707 (2015-09-24)

Mycobacterium leprae induces the formation of lipid droplets, which are recruited to pathogen-containing phagosomes in infected macrophages and Schwann cells. Cholesterol is among the lipids with increased abundance in M. leprae-infected cells, and intracellular survival relies on cholesterol accumulation. The

Podocyte injury in diabetic nephropathy: implications of angiotensin II-dependent activation of TRPC channels.

Daria V Ilatovskaya et al.

Scientific reports, 5, 17637-17637 (2015-12-15)

Injury to podocytes is considered a major contributor to diabetic kidney disease: their loss causes proteinuria and progressive glomerulosclerosis. Podocyte depletion may result from improper calcium handling due to abnormal activation of the calcium permeant TRPC (Transient Receptor Potential Canonical)

In situ DOX-calcium phosphate mineralized CPT-amphiphilic gelatin nanoparticle for intracellular controlled sequential release of multiple drugs.

Wei-Ming Li et al.

Acta biomaterialia, 15, 191-199 (2014-12-30)

A co-delivery strategy has been developed to achieve the synergistic effect of a hydrophobic drug (camptothecin, CPT) and a hydrophilic drug (doxorubicin, DOX) by utilizing the unique structure of amphiphilic gelatin/camptothecin @calcium phosphate-doxorubicin (AG/CPT@CaP-DOX) nanoparticles as a carriers in order

Layer-by-layer assembled cell instructive nanocoatings containing platelet lysate.

Sara M Oliveira et al.

Biomaterials, 48, 56-65 (2015-02-24)

Great efforts have been made to introduce growth factors (GFs) onto 2D/3D constructs in order to control cell behavior. Platelet lysate (PL) presents itself as a cost-effective source of multiple GFs and other proteins. The instruction given by a construct-PL

Size and surface functionalization of iron oxide nanoparticles influence the composition and dynamic nature of their protein corona.

Jonathan Ashby et al.

ACS applied materials & interfaces, 6(17), 15412-15419 (2014-08-22)

Nanoparticles (NPs) adsorb proteins when in the biological matrix, and the resulted protein corona could affect NP-cell interactions. The corona has a dynamic nature with the adsorbed proteins constantly exchanging with the free proteins in the matrix at various rates.

Transcriptional coordination and abscisic acid mediated regulation of sucrose transport and sucrose-to-starch metabolism related genes during grain filling in wheat (Triticum aestivum L.).

Shalini Mukherjee et al.

Plant science : an international journal of experimental plant biology, 240, 143-160 (2015-10-18)

Combining physiological, molecular and biochemical approaches, this study investigated the transcriptional coordination and abscisic acid (ABA) mediated regulation of genes involved in sucrose import and its conversion to starch during grain filling in wheat. Sucrose import appears to be mediated

Blockade of the intermediate-conductance Ca(2+)-activated K+ channel inhibits the angiogenesis induced by epidermal growth factor in the treatment of corneal alkali burn.

Huike Yang et al.

Experimental eye research, 110, 76-87 (2013-03-14)

Epidermal growth factor (EGF) is used to treat alkali-burned corneas. However, EGF-induced corneal angiogenesis, which is currently untreatable, is a side effect of this therapy. We therefore explored the role of the intermediate-conductance Ca(2+)-activated K(+) channel (KCa3.1) in EGF-induced angiogenesis

Enhanced ALP activity of MG63 cells cultured on hydroxyapatite-poly(ethylene glycol) hydrogel composites prepared using EDTA-OH.

Temmei Ito et al.

Biomedical materials (Bristol, England), 10(1), 015025-015025 (2015-03-03)

In order to obtain a hydroxyapatite (HAp)-poly(ethylene glycol) (PEG) composite, tetra amine-terminated PEG was crosslinked using disuccinimidyl tartrate to obtain a PEG hydrogel. Using two kinds of chelators with different stability constants for Ca ion (N-(2-hydroxyethyl) ethylenediamine-N,N',N'-triacetic acid (EDTA-OH, 8.14)

Functional analysis of novel genetic variation in the thyroid hormone activating type 2 deiodinase.

Chantal Zevenbergen et al.

The Journal of clinical endocrinology and metabolism, 99(11), E2429-E2436 (2014-08-21)

Thyroid hormones (TH) are important for normal brain development and abnormal TH regulation in the brain results in neurocognitive impairments. The type 2 deiodinase (D2) is important for local TH control in the brain by generating the active hormone T3

Hydrogen sulphide decreases IL-1β-induced activation of fibroblast-like synoviocytes from patients with osteoarthritis.

Daniela Sieghart et al.

Journal of cellular and molecular medicine, 19(1), 187-197 (2014-10-15)

Balneotherapy employing sulphurous thermal water is still applied to patients suffering from diseases of musculoskeletal system like osteoarthritis (OA) but evidence for its clinical effectiveness is scarce. Since the gasotransmitter hydrogen sulphide (H2 S) seems to affect cells involved in

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