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Taomin Huang et al.
Talanta, 147, 501-509 (2015-11-26)
To the best of our knowledge, this study is the first to successfully apply a novel, highly selective enrichment technique based on boronic acid-functionalized core-shell magnetic microspheres (BA-Fe3O4@SiO2-Au@mSiO2) with a large surface area and uniform pore size, to determine the
Chun Yang et al.
Journal of cellular physiology, 230(10), 2403-2414 (2015-03-03)
Glycation product accumulation during aging of slowly renewing tissues may be an important mechanism underlying aging of the testis. Adipose-derived stem cells (ADSCs) have shown promise in a novel tissue regenerative technique and may have utility in treating sexual dysfunction.
Nilgun Gultiken et al.
Journal of veterinary science, 16(2), 213-219 (2014-12-31)
In the present study, 13 clinical cases of canine mammary adenocarcinoma were evaluated in order to understand the effect of Tarantula cubensis extract (TCE) on tumor tissue. Punch biopsies were taken from the tumors before treatment with TCE. Subcutaneous injections
Zbyněk Tonar et al.
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft, 201, 79-90 (2015-08-02)
The porcine aorta is often used in studies on morphology, pathology, transplantation surgery, vascular and endovascular surgery, and biomechanics of the large arteries. Using quantitative histology and stereology, we estimated the area fraction of elastin, collagen, alpha-smooth muscle actin, vimentin
Suresh Regonda et al.
Biosensors & bioelectronics, 45, 245-251 (2013-03-19)
Here we demonstrate the use of multiple Si nanochannel (NC) or nanograting (NG) instead of the conventional single nanochannel or nanowire design in biosensors. The NG devices can significantly reduce device-to-device variation, and improve device performance, e.g. higher current, higher
Xiao-Huan Liang et al.
The Journal of biological chemistry, 289(34), 23534-23545 (2014-07-12)
Embryo implantation is a highly synchronized process between an activated blastocyst and a receptive uterus. Successful implantation relies on the dynamic interplay of estrogen and progesterone, but the key mediators underlying embryo implantation are not fully understood. Here we show
Giorgi Shtenberg et al.
The Analyst, 140(13), 4507-4514 (2015-05-20)
A generic biosensing platform, based on nanostructured porous Si (PSi), Fabry-Pérot thin films, for label-free monitoring of heavy metal ions in aqueous solutions by enzymatic activity inhibition, is described. First, we show a general detection assay by immobilizing horseradish peroxidase
Ji-Tao Song et al.
Dalton transactions (Cambridge, England : 2003), 44(25), 11314-11320 (2015-05-27)
In this study, silica coated Au nanospheres (Au@SiO2) were prepared by a reverse microemulsion method; subsequently, a layer of fluorescent quantum dots (QDs) were adsorbed onto it and then it was coated with silica again. After modifying with PVP, the
Jun Feng Wang et al.
PloS one, 9(6), e97976-e97976 (2014-06-03)
A new high-performance surface-enhanced Raman scattering (SERS) substrate with extremely high SERS activity was produced. This SERS substrate combines the advantages of Au film over nanosphere (AuFON) substrate and Ag nanoparticles (AgNPs). A three order enhancement of SERS was observed
Silvia Minardi et al.
Small (Weinheim an der Bergstrasse, Germany), 10(19), 3943-3953 (2014-05-29)
The ideal scaffold for regenerative medicine should concurrently mimic the structure of the original tissue from the nano- up to the macroscale and recapitulate the biochemical composition of the extracellular matrix (ECM) in space and time. In this study, a
Hao Wu et al.
PloS one, 10(6), e0130856-e0130856 (2015-06-27)
The opaque-2 (o2) mutation of maize increases lysine content, but the low seed density and soft texture of this type of mutant are undesirable. Lines with modifiers of the soft kernel phenotype (mo2) called "Quality Protein Maize" (QPM) have high
Lu Han et al.
Biomaterials, 60, 42-52 (2015-05-20)
Multi-layered nanocomplexes (MLNs) were designed here to provide smart co-delivery of doxorubicin (DOX) and vascular endothelial growth factor (VEGF) siRNA. The electrostatically self-assembled MLNs were constructed by TAT peptide modified mesoporous silica nanoparticles (TAT-MSN) as the cationic core for DOX
Ana García-Sacristán et al.
Nucleic acids research, 43(1), 565-580 (2014-12-17)
The 5' untranslated region of hepatitis C virus (HCV) genomic RNA contains an internal ribosome entry site (IRES) element, composed of domains II-IV, which is required for cap-independent translation initiation. Little information on the 3D structure of the whole functional
Michael S Gilmore et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(23), 7273-7278 (2015-06-04)
Multidrug-resistant Enterococcus faecalis possess numerous mobile elements that encode virulence and antibiotic resistance traits as well as new metabolic pathways, often constituting over one-quarter of the genome. It was of interest to determine how this large accretion of mobile elements
Minggui Wang et al.
Langmuir : the ACS journal of surfaces and colloids, 31(22), 6220-6228 (2015-05-23)
Yolk@shell nanostructures of Au@r-GO/TiO2 with mesoporous shells were prepared by a sol-gel coating process sequentially with GO and TiO2 on Au/SiO2 core/shell spheres, followed by calcination and template removal, where the silica interlayer acts as a template not only to
Xiao Jiang et al.
Biomedical microdevices, 17(1), 20-20 (2015-02-06)
Growth of the MDA-MB-231 breast cancer cell line in microfluidic channels was inhibited when culture media was delivered to the channels via microbore Tygon® tubing. Culture media incubated within this tubing also inhibited growth of these cells in conventional 96-well
Zhen Zou et al.
Biomaterials, 58, 35-45 (2015-05-06)
The development of multifunctional nanocarrier with each unit functioning at the correct time and location is a challenge for clinical applications. With this in mind, a type of intelligent mesoporous silica nanocarrier (PGFMSN) is proposed for matrix metalloprotease 2 (MMP
S K Vashist et al.
The Analyst, 140(13), 4445-4452 (2015-05-13)
A rapid and highly-sensitive surface plasmon resonance (SPR)-based immunoassay (IA) has been developed and validated for detecting human C-reactive protein (CRP), a specific biomarker for inflammatory and metabolic disorders, and infections. The 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride (EDC)-activated protein A/G (Pr A/G) was
Young-Kwan Kim et al.
Small (Weinheim an der Bergstrasse, Germany), 11(21), 2527-2535 (2015-01-30)
The paper reports a facile one-pot synthesis of core@shell nanoparticles (NPs) composed of Au core and graphene oxide nanocolloid (GON) shell. Unique properties of Au NPs and GON can be incorporated into a single nanohybrid structure to provide desirable functions
Dang-Dang Li et al.
Cell cycle (Georgetown, Tex.), 14(21), 3461-3474 (2015-11-15)
Although Hmgn1 is involved in the regulation of gene expression and cellular differentiation, its physiological roles on the differentiation of uterine stromal cells during decidualization still remain unknown. Here we showed that Hmgn1 mRNA was highly expressed in the decidua
Yunus Alapan et al.
Scientific reports, 4, 7173-7173 (2014-11-25)
We present a microfluidic approach that allows simultaneous interrogation of RBC properties in physiological flow conditions at a single cell level. With this method, we studied healthy hemoglobin A (HbA) and homozygous sickle hemoglobin (HbS) containing RBCs using whole blood
Alireza Ebrahiminezhad et al.
Colloids and surfaces. B, Biointerfaces, 102, 534-539 (2012-10-30)
Nanotechnology has opened new gates to pharmaceutical sciences and medicine from the aspect of drug delivery and imaging systems. Currently, bimodal fluorescent-magnetic nanoparticles are of great interest to biomedical scientists. In order to constructing these kinds of nanoparticles, fluorescent molecules
Jiajia Xue et al.
ACS nano, 9(2), 1600-1612 (2015-01-15)
Guided tissue regeneration/guided bone regeneration membranes with sustained drug delivery were developed by electrospinning drug-loaded halloysite clay nanotubes doped into poly(caprolactone)/gelatin microfibers. Use of 20 wt % nanotube content in fiber membranes allowed for 25 wt % metronidazole drug loading
Yong Shin et al.
Scientific reports, 5, 14127-14127 (2015-09-16)
Sample processing, especially that involving nucleic acid extraction, is a prerequisite step for the isolation of high quantities of relatively pure DNA for downstream analyses in many life science and biomedical engineering studies. However, existing methods still have major problems
Ethan Poteet et al.
PloS one, 10(8), e0136862-e0136862 (2015-08-28)
HIV virus-like particles (VLPs) present the HIV envelope protein in its native conformation, providing an ideal vaccine antigen. To enhance the immunogenicity of the VLP vaccine, we sought to improve upon two components; the route of administration and the additional
Phuong Dinh Tam et al.
Materials science & engineering. C, Materials for biological applications, 58, 953-959 (2015-10-20)
This paper developed a label-free immunosensor based on cerium oxide nanowire for Vibrio cholerae O1 detection application. The CeO2 nanowires were synthesized by hydrothermal reaction. The immobilization of Anti-V. cholerae O1 onto CeO2 nanowire-deposited sensor was performed via an amino
Narjes Allahrabbi et al.
Biomicrofluidics, 9(3), 034110-034110 (2015-07-17)
Assessment of the microbial safety of water resources is among the most critical issues in global water safety. As the current detection methods have limitations such as high cost and long process time, new detection techniques have transpired among which
Zunfang Hu et al.
Journal of environmental sciences (China), 25(1), 181-187 (2013-04-17)
Immobilization of enzymes on mesoporous silicas (MS) allows for good reusability. MS with two-dimensional hexagonal pores in diameter up to 14.13 nm were synthesized using Pluronic P123 as template and 1,3,5-triisopropylbenzene as a swelling agent in acetate buffer. The surface
Homa Homayoni et al.
Photodiagnosis and photodynamic therapy, 12(2), 258-266 (2015-02-01)
Molecular modification of protoporphyrin IX (PpIX) was conducted to improve its water solubility and therapeutic performance for photodynamic therapy. The carboxylic acid and the two nitrogen atoms in the core of PpIX molecule were protonated following by conjugation with 3-aminopropyl
Rahul P Bagwe et al.
Langmuir : the ACS journal of surfaces and colloids, 22(9), 4357-4362 (2006-04-19)
In this article, a systematic study of the design and development of surface-modification schemes for silica nanoparticles is presented. The nanoparticle surface design involves an optimum balance of the use of inert and active surface functional groups to achieve minimal
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