CN
Search Within
840051P
应用筛选条件
关键词:'840051P'
显示 1-30 共 52 条结果 关于 "840051P" 范围 论文
Hana Petroková et al.
Pharmaceutics, 11(12) (2019-12-08)
Development of tools for direct thrombus imaging represents a key step for diagnosis and treatment of stroke. Nanoliposomal carriers of contrast agents and thrombolytics can be functionalized to target blood thrombi by small protein binders with selectivity for fibrin domains
Efficacy of injections of phosphatidylcholine into fat deposits-a non-surgical alternative to liposuction in body-contouring
Karl GH, et al.
Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India, 38(2), 119-119 (2005)
John M Harrington et al.
The Journal of biological chemistry, 284(20), 13505-13512 (2009-03-28)
Trypanosome lytic factor (TLF) is a subclass of human high density lipoprotein (HDL) that mediates an innate immune killing of certain mammalian trypanosomes, most notably Trypanosoma brucei brucei, the causative agent of a wasting disease in cattle. Mechanistically, killing is
Rebba C Boswell-Casteel et al.
The Journal of biological chemistry, 289(35), 24440-24451 (2014-07-19)
Equilibrative nucleoside transporters (ENTs) are polytopic integral membrane proteins that transport nucleosides and, to a lesser extent, nucleobases across cell membranes. ENTs modulate efficacy for a range of human therapeutics and function in a diffusion-controlled bidirectional manner. A detailed understanding
Christina M Bailey et al.
Langmuir : the ACS journal of surfaces and colloids, 33(43), 11986-11997 (2017-09-28)
Supported lipid bilayers (SLBs) have been used extensively in a variety of biotechnology applications and fundamental studies exploring lipid behavior. Despite their widespread use, various physicochemical parameters have yet to be thoroughly investigated for their impact on SLB formation. In
Daniel Calle et al.
Theranostics, 5(5), 489-503 (2015-03-15)
We describe the preparation, physico-chemical characterization and anti-inflammatory properties of liposomes containing the superparamagnetic nanoparticle Nanotex, the fluorescent dye Rhodamine-100 and omega-3 polyunsaturated fatty acid ethyl ester (ω-3 PUFA-EE), as theranostic anti-inflammatory agents. Liposomes were prepared after drying chloroform suspensions
Ashutosh Tripathi et al.
The Journal of biological chemistry, 294(50), 19081-19098 (2019-11-07)
Phosphatidylinositol-transfer proteins (PITPs) are key regulators of lipid signaling in eukaryotic cells. These proteins both potentiate the activities of phosphatidylinositol (PtdIns) 4-OH kinases and help channel production of specific pools of phosphatidylinositol 4-phosphate (PtdIns(4)P) dedicated to specific biological outcomes. In
J Zebialowicz Ahlström et al.
Respiratory research, 20(1), 245-245 (2019-11-07)
In acute respiratory distress syndrome (ARDS) damaged alveolar epithelium, leakage of plasma proteins into the alveolar space and inactivation of pulmonary surfactant lead to respiratory dysfunction. Lung function could potentially be restored with exogenous surfactant therapy, but clinical trials have
Optimizing a ultrahigh pressure liquid chromatography-time of flight-mass spectrometry approach using a novel sub-2 mum core-shell particle for in depth lipidomic profiling of Caenorhabditis elegans
Witting M, et al.
Journal of Chromatography A, 1359, 91-99 (2014)
Kelly Cathcart et al.
Membranes, 5(4), 664-684 (2015-11-04)
Cellular membranes have a complex phospholipid composition that varies greatly depending on the organism, cell type and function. In spite of this complexity, most structural data available for phospholipid bilayers concern model systems containing only one or two different phospholipids.
Johanna M Jansen et al.
PloS one, 12(4), e0174706-e0174706 (2017-04-07)
RAS mutations lead to a constitutively active oncogenic protein that signals through multiple effector pathways. In this chemical biology study, we describe a novel coupled biochemical assay that measures activation of the effector BRAF by prenylated KRASG12V in a lipid-dependent
Austin J Rice et al.
Channels (Austin, Tex.), 8(4), 327-333 (2014-05-24)
In order to shuttle substrates across the lipid bilayer, membrane proteins undergo a series of conformation changes that are influenced by protein structure, ligands, and the lipid environment. To test the effect of lipid on conformation change of the ABC
Xiaoke Chi et al.
eLife, 9 (2020-01-25)
The Bcl-2 family BH3 protein Bim promotes apoptosis at mitochondria by activating the pore-forming proteins Bax and Bak and by inhibiting the anti-apoptotic proteins Bcl-XL, Bcl-2 and Mcl-1. Bim binds to these proteins via its BH3 domain and to the
Integrative Medicine - E-Book (2017)
Christian Bogner et al.
Molecular cell, 77(4), 901-912 (2020-02-01)
Current models of apoptosis regulation by the Bcl-2 family of proteins postulate that heterodimeric interactions between family members determine whether Bax and Bak are activated to trigger cell death. Thus, the relative abundance and binding affinities between pro- and anti-apoptotic
Austin J Rice et al.
The Journal of biological chemistry, 289(21), 15005-15013 (2014-04-12)
Embedded in the plasma membrane of all bacteria, ATP binding cassette (ABC) importers facilitate the uptake of several vital nutrients and cofactors. The ABC transporter, MolBC-A, imports molybdate by passing substrate from the binding protein MolA to a membrane-spanning translocation
Sonia Hernández-Tiedra et al.
Autophagy, 12(11), 2213-2229 (2016-11-02)
Autophagy is considered primarily a cell survival process, although it can also lead to cell death. However, the factors that dictate the shift between these 2 opposite outcomes remain largely unknown. In this work, we used Δ9-tetrahydrocannabinol (THC, the main
Jingchuan Sun et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(4), 1354-1359 (2007-01-18)
This study concerns the self-assembly of virus-like particles (VLPs) composed of an icosahedral virus protein coat encapsulating a functionalized spherical nanoparticle core. The recent development of efficient methods for VLP self-assembly has opened the way to structural studies. Using electron
Qualitative and quantitative characterization of protein-phosphoinositide interactions with liposome-based methods
Busse RA, et al.
Autophagy, 9(5), 770-777 (2013)
John M Harrington et al.
The Journal of biological chemistry, 289(36), 24811-24820 (2014-07-20)
Haptoglobin-related protein (Hpr) is a component of a minor subspecies of high density lipoproteins (HDL) that function in innate immunity. Here we show that assembly of Hpr into HDL is mediated by its retained N-terminal signal peptide, an unusual feature
Qiang Cheng et al.
Nature nanotechnology, 15(4), 313-320 (2020-04-07)
CRISPR-Cas gene editing and messenger RNA-based protein replacement therapy hold tremendous potential to effectively treat disease-causing mutations with diverse cellular origin. However, it is currently impossible to rationally design nanoparticles that selectively target specific tissues. Here, we report a strategy
Anne Araye et al.
PloS one, 11(4), e0153401-e0153401 (2016-04-14)
Botulinum neurotoxin A (BoNT/A) is composed of three domains: a catalytic domain (LC), a translocation domain (HN) and a receptor-binding domain (HC). Like most bacterial toxins BoNT/A is an amphitropic protein, produced in a soluble form that is able to
Ricarda A Busse et al.
Autophagy, 9(5), 770-777 (2013-03-01)
We characterized phosphoinositide binding of the S. cerevisiae PROPPIN Hsv2 qualitatively with density flotation assays and quantitatively through isothermal titration calorimetry (ITC) measurements using liposomes. We discuss the design of these experiments and show with liposome flotation assays that Hsv2
Yuki Nakamura et al.
Nature communications, 5, 3553-3553 (2014-04-05)
Arabidopsis FT protein is a component of florigen, which transmits photoperiodic flowering signals from leaf companion cells to the shoot apex. Here, we show that FT specifically binds phosphatidylcholine (PC) in vitro. A transgenic approach to increase PC levels in
Andrew A Bridges et al.
The Journal of cell biology, 213(1), 23-32 (2016-04-06)
Cells change shape in response to diverse environmental and developmental conditions, creating topologies with micron-scale features. Although individual proteins can sense nanometer-scale membrane curvature, it is unclear if a cell could also use nanometer-scale components to sense micron-scale contours, such
Daichi Yamaura et al.
Langmuir : the ACS journal of surfaces and colloids, 34(19), 5615-5622 (2018-04-18)
Artificial bilayer lipid membranes (BLMs) provide well-defined systems for investigating the fundamental properties of membrane proteins, including ion channels, and for screening the effect of drugs that act on them. However, the application of this technique is limited due to
Detection and quantification of angiogenesis in experimental valve disease with integrin-targeted nanoparticles and 19-fluorine MRI/MRS
Waters EA, et al.
Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance, 10(1), 43-43 (2008)
Yuanjie Pang et al.
Biomedical optics express, 7(5), 1672-1689 (2016-05-28)
The refractive index (RI) is a fundamental parameter of materials that can be used to distinguish and sort materials of different nature. Although the RI of a virus is required for many optics-based biosensing applications, RIs of animal viruses have
Dieter R Klopfenstein et al.
Cell, 109(3), 347-358 (2002-05-23)
Unc104 (KIF1A) kinesin transports membrane vesicles along microtubules in lower and higher eukaryotes. Using an in vitro motility assay, we show that Unc104 uses a lipid binding pleckstrin homology (PH) domain to dock onto membrane cargo. Through its PH domain
Małgorzata A Przeradzka et al.
Journal of thrombosis and haemostasis : JTH, 18(2), 364-372 (2019-11-02)
The identity of the amino acid regions of factor VIII (FVIII) that contribute to factor IXa (FIXa) and von Willebrand factor (VWF) binding has not been fully resolved. Previously, we observed that replacing the FVIII C1 domain for the one
1/2