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显示 1-30 共 141 条结果 关于 "A2512" 范围 论文
S B Wang et al.
Scandinavian journal of immunology, 78(6), 507-515 (2013-10-12)
Lactoferrin (LF) can downregulate allergic airway inflammation in asthma. However, the in vivo effect of exogenous LF on allergic rhinitis (AR), a disease attributed to airway inflammation, has yet to be determined. We investigated the effect of intranasal administration recombinant
Saki Kawashima et al.
International archives of allergy and immunology, 161 Suppl 2, 118-124 (2013-06-05)
Recent studies have shown that prolonged Th2-type immune inflammation in the lung induces pulmonary arterial remodeling, in part through the induction of resistin-like molecule α (RELMα) expression. However, the role of interleukin-25 (IL-25; which promotes this inflammation) in the development
Cynthia Kanagaratham et al.
American journal of respiratory cell and molecular biology, 51(6), 783-792 (2014-06-03)
Arachidonic acid (AA) and docosahexaenoic acid (DHA) play important roles in inflammation and disease progression, where AA is viewed as proinflammatory and DHA as antiinflammatory. We observe in our model of allergic asthma that the AA/DHA ratio is significantly skewed
Karin M Knudson et al.
Journal of immunology (Baltimore, Md. : 1950), 191(12), 5797-5801 (2013-11-19)
CD8 T cell memory critically contributes to long-term immunity. Both low- and high-affinity TCR signals are able to support the differentiation of memory CD8 T cells. However, it is unclear whether the requirements for memory development change when TCR signal
Ruchi Roy et al.
Toxicology letters, 230(3), 421-433 (2014-08-17)
Our previous studies indicated that zinc oxide nanoparticles (ZnO NPs) have adjuvant properties to a known allergen ovalbumin (OVA) in Balb/c mice. Therefore, in this study, we focused on the mechanisms involved in adjuvant responses induced by ZnO NPs. The
PTP1B deficiency exacerbates inflammation and accelerates leukocyte trafficking in vivo
<BIG>Berdnikovs S, et al.</BIG>
Journal of Immunology, 188, 874-884 (2012)
Preety Sahdev et al.
Journal of biomedical nanotechnology, 9(1), 132-141 (2013-05-01)
The main objective of this study was to investigate the potential of calcium phosphate (CAP) nanoparticles for transcutaneous vaccine delivery. CAP nanoparticles were prepared by nanoprecipitation method followed by sequential adsorption of sugars and ovalbumin. Nanoparticles were characterized using dynamic
Oliver T Burton et al.
The Journal of allergy and clinical immunology, 134(6), 1310-1317 (2014-07-22)
Food-induced anaphylaxis is triggered by specific IgE antibodies. Paradoxically, some subjects with significant IgE levels can ingest allergenic foods without incident. Similarly, subjects completing oral immunotherapy (OIT) tolerate food challenges despite persistent high-titer food-specific IgE. We sought to test whether
JangEun Lee et al.
Journal of immunology (Baltimore, Md. : 1950), 192(7), 3190-3199 (2014-02-26)
Fatty acids (FAs) are essential constituents of cell membranes, signaling molecules, and bioenergetic substrates. Because CD8(+) T cells undergo both functional and metabolic changes during activation and differentiation, dynamic changes in FA metabolism also occur. However, the contributions of de
M Antošová et al.
Advances in experimental medicine and biology, 838, 1-10 (2014-09-26)
Nitric oxide (NO) effects in airways are influenced by the activity of NO-synthase isoforms and NO metabolism. Inducible NO-synthase (iNOS), which produces large amounts of NO, is active during the inflammatory process. NO quickly reacts, producing reactive oxygen species (ROS).
Alison J Hodgkinson et al.
The British journal of nutrition, 112(3), 390-397 (2014-05-30)
Epidemiological studies have shown an association between the consumption of raw farm milk and reduced incidence of allergy. In the present study, we fed untreated raw milk, gamma-sterilised milk, heat-treated milk or water to mice and compared their responses to
A differential scanning calorimetric study of conversion of ovalbumin to S-ovalbumin in eggs.
J W Donovan et al.
Journal of the science of food and agriculture, 27(2), 197-204 (1976-02-01)
Sumbul Afroz et al.
Nanoscale, 9(38), 14641-14653 (2017-09-25)
The application of nanotechnology in vaccinology has fuelled rapid advancement towards the design and development of nanovaccines. Nanoparticles have been found to enhance vaccine efficacy through the spatiotemporal orchestration of antigen delivery to secondary lymphoid organs and antigen-presentation by Antigen
Shin Yoshino et al.
Immunology, 141(4), 617-627 (2013-12-07)
Fab fragments (Fabs) maintain the ability to bind to specific antigens but lack effector functions due to the absence of the Fc portion. In the present study, we tested whether Fabs of an allergen-specific monoclonal antibody (mAb) were able to
Christianne Bandeira-Melo et al.
Journal of immunological methods, 276(1-2), 227-237 (2003-05-10)
Eosinophils contain several preformed cytokines within their specific granules. Therefore, without requiring them in de novo synthesis of cytokines, eosinophils can release quantities of granule-derived cytokines by highly regulated mechanisms. However, eosinophil "degranulation" is poorly understood, in part, because available
M Ritter et al.
Clinical and experimental immunology, 178(2), 212-223 (2014-06-20)
Overall asthmatic symptoms can be controlled with diverse therapeutic agents. However, certain symptomatic individuals remain at risk for serious morbidity and mortality, which prompts the identification of novel therapeutic targets and treatment strategies. Thus, using an adjuvant-free T helper type
Hannah E Cummings et al.
Journal of immunology (Baltimore, Md. : 1950), 191(12), 5807-5810 (2013-11-19)
Leukotriene C4 (LTC4) and its extracellular metabolites, LTD4 and LTE4, mediate airway inflammation. They signal through three specific receptors (type 1 cys-LT receptor [CysLT1R], CysLT2R, and GPR99) with overlapping ligand preferences. In this article, we demonstrate that LTC4, but not
Kamal Srivastava et al.
American journal of physiology. Lung cellular and molecular physiology, 305(12), L1002-L1010 (2013-10-29)
Our previous studies have shown that the anti-asthma traditional Chinese medicine herbal formula ASHMI (anti-asthma simplified herbal medicine intervention) inhibits acetylcholine-induced contractions of tracheal rings from ovalbumin-sensitized and naive mice in a β-adrenoceptor-independent manner. We sought to determine whether acute
André C Dumetz et al.
Biochimica et biophysica acta, 1784(4), 600-610 (2008-02-09)
The effects of pH on protein interactions and protein phase behavior were investigated by measuring the reduced second osmotic virial coefficient (b2) for ovalbumin and catalase, and the aggregate and crystal solubilities for ovalbumin, beta-lactoglobulin A and B, ribonuclease A
Chakkrit Khanaree et al.
Oncology research, 20(9), 427-435 (2013-08-09)
Maspin, a tumor suppressor (SERPINB5), inhibits cancer migration, invasion, and metastasis in vitro and in vivo. The tumor-suppressing effects of maspin depend in part on its ability to enhance cell adhesion to extracellular matrix. Although the molecular mechanism of maspin's
Chia-Chi Wang et al.
BMC complementary and alternative medicine, 13, 154-154 (2013-07-03)
Arecae semen, the dried slice of areca nuts, is a traditional Chinese medicine used to treat intestinal parasitosis, rectal tenesmus and diarrhea. Areca nuts contain a rich amount of polyphenols that have been shown to modulate the functionality of mast
So Ri Kim et al.
The Journal of allergy and clinical immunology, 132(6), 1397-1408 (2013-10-29)
Despite many studies on endoplasmic reticulum (ER) stress in patients with various inflammatory diseases, there is scarce information on ER stress in patients with bronchial asthma. In this study we aimed to elucidate the role of ER stress in the
Jaba Gamrekelashvili et al.
The Journal of clinical investigation, 123(11), 4755-4768 (2013-11-13)
Cross-priming of CD8+ T cells and generation of effector immune responses is pivotal for tumor immunity as well as for successful anticancer vaccination and therapy. Dead and dying cells produce signals that can influence Ag processing and presentation; however, there
Louisa J Mathias et al.
Journal of immunology (Baltimore, Md. : 1950), 191(12), 5914-5924 (2013-11-20)
Multipotent mesenchymal stromal cells (MSCs) possess reparative and immunoregulatory properties, making them attractive candidates for cellular therapy. However, the majority of MSCs administered i.v. encounter a pulmonary impasse and soon disappear from the lungs, raising the question of how they
Ryosuke Matsumura et al.
Scientific reports, 8(1), 9905-9905 (2018-07-04)
The electrical impedance of cell membranes is important for excitable cells, such as neurons, because it strongly influences the amount of membrane potential change upon a flow of ionic current across the membrane. Here, we report on an investigation of
Benjamin Brinkhoff et al.
European journal of immunology, 44(4), 1213-1224 (2013-12-18)
Immunotherapy of solid tumors is often hampered by the low frequency of tumor-specific T cells elicited by current vaccination strategies. Here, we describe a prime-boost vaccination protocol based on the administration of antigen conjugated to poly-lactic-co-glycolic acid (PLGA) microspheres followed
Anurag Singh et al.
The British journal of nutrition, 112(3), 358-368 (2014-05-24)
Polyphenols are naturally derived bioactive compounds with numerous reported health benefits. We have previously reported on the beneficial effect of a polyphenol-enriched apple extract in a murine model of food allergy. The objectives of the present study were to elucidate
Tao Chen et al.
Asian Pacific journal of allergy and immunology, 32(4), 345-353 (2014-12-30)
The intestinal tract plays an important role in food allergy and the intestinal mucosa barrier is critical for maintenance of its function. The underlying mechanisms of how food allergens modulate the intestinal permeability in inducing intestinal food allergy remain elusive.
Ryoko Hamano et al.
European journal of immunology, 44(4), 1005-1015 (2013-12-18)
An intravenous administration of a high-dose antigen (Ag) can induce immune tolerance and suppress the immune response, but the mechanism remains unclear. We recently proved that a combined i.v. administration of OVA and IL-2-anti-IL-2 Ab immune complexes (IL-2 ICs) efficiently
Bum Soo Park et al.
Radiation research, 179(5), 570-583 (2013-04-09)
Gamma radiation is used for several therapeutic indications such as cancers and autoimmune diseases. Low-dose whole-body γ irradiation has been shown to activate immune responses in several ways, however, the effect and mechanism of irradiation on allergic asthma remains poorly
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