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Ziaurahman Roeen et al.
Cellular immunology, 293(1), 34-40 (2014-12-17)
Eosinophils and mast cells play critical roles in the pathogenesis of bronchial asthma. Activation of both cells leads to the release of pro-inflammatory mediators in the airway of asthmatic patients. Recently, we have shown that inhaled thrombomodulin inhibits allergic bronchial
Ming-Xu Xia et al.
Journal of neuroimmunology, 273(1-2), 53-57 (2014-07-06)
Chronic asthma is one of the most common respiratory diseases, characterized by airway inflammation. However, little is known whether asthma-induced airway inflammation might influence the brain. We found that chronic asthma not only resulted in peripheral inflammation, but also induced
Natacha Scarafone et al.
PloS one, 7(3), e31253-e31253 (2012-03-23)
Nine neurodegenerative disorders, called polyglutamine (polyQ) diseases, are characterized by the formation of intranuclear amyloid-like aggregates by nine proteins containing a polyQ tract above a threshold length. These insoluble aggregates and/or some of their soluble precursors are thought to play
Guido Heine et al.
Journal of immunology (Baltimore, Md. : 1950), 193(3), 1017-1023 (2014-06-22)
Calcitriol (1α,25-dihydroxyvitamin D3) is the active vitamin D metabolite and mediates immunological functions, which are relevant in allergy. Its therapeutic use is limited by hypercalcaemic toxicity. We have previously shown that the activation of the vitamin D receptor inhibits IgE
Steven M Blaauboer et al.
Journal of immunology (Baltimore, Md. : 1950), 192(1), 492-502 (2013-12-07)
The bacterial second messenger (3'-5')-cyclic-di-guanosine-monophosphate (CDG) is a promising mucosal adjuvant candidate that activates balanced Th1/Th2/Th17 responses. We showed previously that CDG activates stimulator of IFN genes (STING)-dependent IFN-I production in vitro. However, it is unknown whether STING or IFN-I
Shinji Toki et al.
Journal of leukocyte biology, 94(1), 77-88 (2013-04-30)
PGI₂ signaling through IP inhibits allergen-induced inflammatory responses in mice. We reported previously that PGI₂ analogs decreased proinflammatory cytokine and chemokine production by mature BMDCs. However, whether PGI₂ modulates the function of immature DCs has not been investigated. We hypothesized
Joel R Wilmore et al.
Journal of immunology (Baltimore, Md. : 1950), 191(9), 4731-4739 (2013-10-02)
High rates of coinfection occur in malaria endemic regions, leading to more severe disease outcomes. Understanding how coinfecting pathogens influence the immune system is important in the development of treatment strategies that reduce morbidity and mortality. Using the Plasmodium chabaudi
Adam Williams et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(17), 6955-6960 (2013-04-10)
The T helper type 2 (Th2) cytokine genes Il4, Il5, and Il13 are contained within a 140-kb region of mouse chromosome 11 and their expression is controlled by a locus control region (LCR) embedded within this locus. The LCR is
Experimental protein mixture for validating tandem mass spectral analysis
<BIG>Keller A, et al.</BIG>
Omics : A Journal of Integrative Biology, 6, 207-212 (2002)
Manuela Flórido et al.
Journal of immunology (Baltimore, Md. : 1950), 191(1), 302-311 (2013-05-24)
Individuals infected with mycobacteria are likely to experience episodes of concurrent infections with unrelated respiratory pathogens, including the seasonal or pandemic circulating influenza A virus strains. We analyzed the impact of influenza A virus and mycobacterial respiratory coinfection on the
T Sakurai et al.
Clinical and experimental immunology, 178(1), 65-74 (2014-06-20)
Invariant natural killer T (iNKT) cells play important immunoregulatory functions in allergen-induced airway hyperresponsiveness and inflammation. To clarify the role of iNKT cells in allergic rhinitis (AR), we generated bone marrow-derived dendritic cells (BMDCs), which were pulsed by ovalbumin (OVA)
A D Nisbet et al.
European journal of biochemistry, 115(2), 335-345 (1981-04-01)
The complete amino acid sequence of hen ovalbumin, comprising 385 residues, has been determined. The sequence was deduced from the 17 cyanogen bromide fragments and from peptides derived by digestion with a number of proteolytic enzymes. The molecular weight of
Patrick Trépanier et al.
Immunology, 141(2), 233-241 (2013-10-17)
Intravenous immunoglobulin (IVIg) is successfully used in the treatment of autoimmune diseases involving self-reactive CD8(+) T cells. However, its direct influence on the cytotoxic response remains unknown. Using an antigen cross-presentation assay and a mouse model of ovalbumin (OVA) immunization
J Kelley Bentley et al.
The Journal of allergy and clinical immunology, 134(6), 1433-1442 (2014-07-06)
Periostin, a secreted extracellular matrix protein, has been localized to deposits of subepithelial fibrosis in asthmatic patients, and periostin levels have been linked to increases in IL-13. We hypothesized that periostin is required for airway inflammatory responses to a physiologic
Yosuke Kumamoto et al.
Immunity, 39(4), 733-743 (2013-10-01)
Unlike other types of T helper (Th) responses, whether the development of Th2 cells requires instruction from particular subset of dendritic cells (DCs) remains unclear. By using an in vivo depletion approach, we have shown that DCs expressing CD301b were
Niels-Erik Viby et al.
Endocrinology, 154(12), 4503-4511 (2013-10-05)
The incretin hormone glucagon-like peptide-1 (GLP-1) is an important insulin secretagogue and GLP-1 analogs are used for the treatment of type 2 diabetes. GLP-1 displays antiinflammatory and surfactant-releasing effects. Thus, we hypothesize that treatment with GLP-1 analogs will improve pulmonary
Mohammad Hossein Boskabady et al.
Experimental biology and medicine (Maywood, N.J.), 238(2), 200-208 (2013-04-12)
The effects of carvacrol on tracheal responsiveness (TR) to methacholine and ovalbumin (OA), serum nitric oxide (NO) concentration, total and differential white blood cells (WBC) in blood of sensitized guinea pigs were examined. Five groups of guinea pigs sensitized to
Daria Esterházy et al.
Nature, 569(7754), 126-130 (2019-04-17)
The intestinal immune system has the challenging task of tolerating foreign nutrients and the commensal microbiome, while excluding or eliminating ingested pathogens. Failure of this balance leads to conditions such as inflammatory bowel diseases, food allergies and invasive gastrointestinal infections1.
Kathrin Straubinger et al.
The Journal of allergy and clinical immunology, 134(6), 1271-1279 (2014-07-22)
Schistosomiasis, a chronic helminth infection, elicits distinct immune responses within the host, ranging from an initial TH1 and subsequent TH2 phase to a regulatory state, and is associated with dampened allergic reactions within the host. We sought to evaluate whether
<BIG>Mielenz JR, et al.</BIG>
Biotechnology for Fuels and Chemicals: The Twenty-Eighth Symposium.c, 928-928 (2019)
Sheng Zeng et al.
The Journal of asthma : official journal of the Association for the Care of Asthma, 51(4), 360-365 (2014-02-26)
It has been reported that adoptive transfer of γδ T cells increases the cellular infiltration, especially eosinophils, in the lungs of allergic mice, suggesting that γδ T cells may play a proinflammatory role in allergic airway inflammation. Respiratory syncytial virus
Yui Hamada et al.
International archives of allergy and immunology, 174(3-4), 113-120 (2017-11-14)
In a previous study, we reported that interleukin-4 production was reduced in spleen cells of mice administered 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF), which is a polymethoxyflavone found at high concentrations in the peel of various citrus fruits. In this study, we investigated the
Nanna Fyhrquist et al.
The Journal of allergy and clinical immunology, 134(6), 1301-1309 (2014-09-30)
The human commensal microbiota interacts in a complex manner with the immune system, and the outcome of these interactions might depend on the immune status of the subject. Previous studies have suggested a strong allergy-protective effect for Gammaproteobacteria. Here we
Hasan Yuksel et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 110(3), 150-155 (2013-04-04)
Vascular endothelial growth factor (VEGF) is an important mediator of the neoangiogenesis component of remodeling in asthma. To evaluate the influence of VEGF blockage on airway remodeling, specifically epithelium thickness, subepithelial smooth muscle thickness, number of mast and goblet cells
Federica Moalli et al.
The Journal of experimental medicine, 211(13), 2507-2517 (2014-12-10)
Interactions between dendritic cells (DCs) and T cells control the decision between activation and tolerance induction. Thromboxane A2 (TXA2) and its receptor TP have been suggested to regulate adaptive immune responses through control of T cell-DC interactions. Here, we show
Zheng-Rong Chen et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 111(4), 276-281 (2013-09-24)
B7 molecules play a key role in regulating allergen-induced T cell activation in asthma, which may occur through T cell recruitment and T helper cell differentiation on allergen provocation. Initial studies have shown that B7-H3 (CD276), a recently identified B7
Haixia Liu et al.
Immunology, 142(1), 78-88 (2013-12-18)
Aspergillus fumigatus is often associated in asthmatic patients with the exacerbation of asthma symptoms. The pathomechanism of this phenomenon has not been fully understood. Here, we evaluated the immunological mechanisms and the role of the prostaglandin D2 / Chemoattractant Receptor-Homologous
Yosuke Hashimoto et al.
Toxicology and applied pharmacology, 277(1), 30-38 (2014-03-19)
PEGylation, the attachment of polyethylene glycol (PEG) to nanocarriers and proteins, is a widely accepted approach to improving the in vivo efficacy of the non-PEGylated products. However, both PEGylated liposomes and PEGylated proteins reportedly trigger the production of specific antibodies
Mohammad S Yousef et al.
Protein science : a publication of the Protein Society, 17(5), 908-917 (2008-03-29)
Miranda is a multidomain adaptor protein involved in neuroblast asymmetric division in Drosophila melanogaster. The central domain of Miranda is necessary for cargo binding of the neural transcription factor Prospero, the Prospero-mRNA carrier Staufen, and the tumor suppressor Brat. Here
Sophie Réhault-Godbert et al.
The Journal of biological chemistry, 288(24), 17285-17295 (2013-04-26)
Ovalbumin family contains three proteins with high sequence similarity: ovalbumin, ovalbumin-related protein Y (OVAY), and ovalbumin-related protein X (OVAX). Ovalbumin is the major egg white protein with still undefined function, whereas the biological activity of OVAX and OVAY has not
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