CN
Search Within
A3782
应用筛选条件
关键词:'A3782'
显示 1-30 共 69 条结果 关于 "A3782" 范围 论文
Margie N Sutton et al.
Cancers, 11(4) (2019-04-21)
Autophagy can protect cancer cells from acute starvation and enhance resistance to chemotherapy. Previously, we reported that autophagy plays a critical role in the survival of dormant, drug resistant ovarian cancer cells using human xenograft models and correlated the up-regulation
Shiro Koizume et al.
Molecular cancer, 14, 77-77 (2015-04-17)
Elucidation of the molecular mechanisms by which cancer cells overcome hypoxia is potentially important for targeted therapy. Complexation of hypoxia-inducible factors (HIFs) with aryl hydrocarbon receptor nuclear translocators can enhance gene expression and initiate cellular responses to hypoxia. However, multiple
Julius Müller et al.
Acta biomaterialia, 71, 420-431 (2018-03-11)
The interaction of nanocarriers with blood plasma components influences the biological response, and therefore, it needs to be controlled. Whereas protein adsorption to nanocarriers has been investigated to a large extent, the role of lipid interaction for drug delivery and
Kevin E Bruce et al.
Journal of bacteriology, 200(11) (2018-03-28)
Antimicrobial peptides (AMPs), including chemokines, are produced during infections to kill pathogenic bacteria. To fill in gaps in knowledge about the sensitivities of Streptococcus pneumoniae and related Streptococcus species to chemokines and AMPs, we performed a systematic, quantitative study of
Martina Zatloukalova et al.
Redox biology, 24, 101213-101213 (2019-06-07)
Nitro-fatty acids modulate inflammatory and metabolic stress responses, thus displaying potential as new drug candidates. Herein, we evaluate the redox behavior of nitro-oleic acid (NO2-OA) and its ability to bind to the fatty acid transporter human serum albumin (HSA). The
Alexei S Kazakov et al.
Journal of biomolecular structure & dynamics, 35(1), 78-91 (2016-01-05)
Interleukin-11 (IL-11) is a hematopoietic cytokine engaged in numerous biological processes and validated as a target for treatment of various cancers. IL-11 contains intrinsically disordered regions that might recognize multiple targets. Recently we found that aside from IL-11RA and gp130
Audra A Winder et al.
Respiratory research, 10, 96-96 (2009-10-20)
The recognition of microbial molecular patterns via toll-like receptors (TLRs) is critical for mucosal defenses. Using well-differentiated primary cultures of human airway epithelia, we investigated the effects of exposure of the cells to cytokines (TNF-alpha and IFN-gamma) and dexamethasone (dex)
The role of fresh cow's milk in iron deficiency: I. Albumin turnover in infants with iron deficiency anemia
Woodruff C W and Clark J L
American Journal of Diseases of Children, 124(1), 18-23 (1972)
Ray R Zhang et al.
Molecular pharmaceutics, 16(8), 3350-3360 (2019-05-15)
Alkylphosphocholine (APC) analogs are a novel class of broad-spectrum tumor-targeting agents that can be used for both diagnosis and treatment of cancer. The potential for clinical translation for APC analogs will strongly depend on their pharmacokinetic (PK) profiles. The aim
Isabel Correia et al.
Chemistry, an Asian journal, 12(16), 2062-2084 (2017-06-27)
[VO(acac)
D Sevillano et al.
The Journal of antimicrobial chemotherapy, 60(1), 156-158 (2007-05-08)
Attempts to interpret antibiotic pharmacodynamics using reported protein binding may underestimate true activity. To elucidate this issue we examined bacterial killing kinetics at cefditoren concentrations equal to C(max) in the presence of 90% human serum or albumin at physiological concentrations.
Deanna L Mendez et al.
Archives of biochemistry and biophysics, 444(2), 92-99 (2005-11-29)
We monitored the unfolding of human serum albumin (HSA) and glycated human serum albumin (gHSA) subjected to guanidine hydrochloride (GndHCl) by using fluorescence and circular dichroism (CD) spectroscopy. A two-state model with sloping baselines best described the Trp-214 fluorescence unfolding
Victor A McPherson et al.
Molecular and cellular biology, 29(2), 389-401 (2008-11-13)
This study investigates the roles of Fer-CIP4 homology (FCH)-Bin/amphiphysin/Rvs (F-BAR) and SH2 domains of Fes protein tyrosine kinase in regulating its activation and signaling downstream of the high-affinity immunoglobulin G (IgE) receptor (FcepsilonRI) in mast cells. Homology modeling of the
Amogh S Deshpande et al.
International journal of biological macromolecules, 128, 923-933 (2019-02-05)
Streptozocin (STZ) is a broad range antibiotic, highly genotoxic, antineoplastic and hyperglycemic. HSA is the most abundant protein in physiology and it binds to almost all exogenic and endogenic ligands, including drugs. STZ-induced fluorescence quenching of HSA has been done
Claudio Dalvit et al.
Magnetic resonance in chemistry : MRC, 55(2), 106-114 (2016-08-16)
Ligand-based
Alexey S Chubarov et al.
Bioorganic & medicinal chemistry, 23(21), 6943-6954 (2015-10-16)
Straightforward and reliable tools for in vivo imaging of tumors can benefit the studies of cancer development, as well as contribute to successful diagnosis and treatment of cancer. (19)F NMR offers an exceptional quantitative way of in vivo imaging of
Fibrillation and Polymorphism of Human Serum Albumin
Bio-nanoimaging, 77(2), 345-362 (2014)
Utsab R Shrestha et al.
The journal of physical chemistry. B, 121(5), 923-930 (2017-01-13)
In this article, we elucidate the protein activity from the perspective of protein softness and flexibility by studying the collective phonon-like excitations in a globular protein, human serum albumin (HSA), and taking advantage of the state-of-the-art inelastic X-ray scattering (IXS)
Anubha Seth et al.
Cellular signalling, 68, 109538-109538 (2020-01-14)
Mammalian adenylate cyclases (ACs) are pseudoheterodimers with dissimilar hexahelical membrane-anchors, isoform-specifically conserved for more than half a billion years. We exchanged both membrane anchors of the AC isoform 2 by the quorum-sensing receptor from Vibrio harveyi, CqsS, which has a
Hassan Sarker et al.
Scientific reports, 9(1), 4340-4340 (2019-03-15)
Non-genetic MMP-2 insufficiency is a relatively unexplored condition which could be induced by pathological overexpression of endogenous MMP-2 inhibitors such as TIMPs and/or the acute phase reactant alpha-2-macroglobulin. Here, we investigate the hypothesis that human fibrinogen (FBG) - an acute
Harald Olsen et al.
BMC clinical pharmacology, 4, 4-4 (2004-03-30)
Albumin is the most abundant protein in blood plasma, and due to its ligand binding properties, serves as a circulating depot for endogenous and exogenous (e.g. drugs) compounds. Hence, the unbound drug is the pharmacologically active drug. Commercial human albumin
Stephanie K Aoki et al.
Molecular microbiology, 70(2), 323-340 (2008-09-03)
Contact-dependent growth inhibition (CDI) is a phenomenon by which bacterial cell growth is regulated by direct cell-to-cell contact via the CdiA/CdiB two-partner secretion system. Characterization of mutants resistant to CDI allowed us to identify BamA (YaeT) as the outer membrane
Trine Salomón et al.
Cell chemical biology, 24(8), 935-943 (2017-08-19)
The α-oxoaldehyde methylglyoxal is a ubiquitous and highly reactive metabolite known to be involved in aging- and diabetes-related diseases. If not detoxified by the endogenous glyoxalase system, it exerts its detrimental effects primarily by reacting with biopolymers such as DNA
Holger Fuchs et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 33(2), 115-122 (2017-01-06)
The ocular half-life of intravitreally (IVT) injected drugs is of major relevance for the suitability of a drug intended for chronic intraocular treatment, as the half-life determines the dosing frequency. Thus, half-life extension principles are very attractive as they can
Zhenping Liu et al.
The review of diabetic studies : RDS, 5(4), 232-244 (2009-03-19)
The influence of glucose and fatty acids on beta-cell function is well established whereas little is known about the role of amino acids (AAs). Islets isolated from NMRI mice were incubated overnight. After preincubation, isolated islets as well as clonal
Molecular Insights and Functional Consequences of the Interaction of Heme with Activated Protein C.
Hopp, et al.
Antioxidants & Redox Signaling, 34, 32-48 (2021)
Jae Hyeon Park et al.
Colloids and surfaces. B, Biointerfaces, 180, 306-312 (2019-05-10)
Human serum albumin (HSA) is one of the most abundant proteins in the human body and also used as a biomaterial coating. While there is significant interest in modifying the properties of solid supports to control HSA adsorption, there is
Mark Duerkop et al.
Biotechnology journal, 13(7), e1800062-e1800062 (2018-03-27)
The reported impact of shear stress on protein aggregation has been contradictory. At high shear rates, the occurrence of cavitation or entrapment of air is reasonable and their effects possibly misattributed to shear stress. Nine different proteins (α-lactalbumin, two antibodies
Competitive adsorption of fibrinogen and albumin and blood platelet adhesion on surfaces modified with nanoparticles and/or PEO
Nonckreman C J, et al.
Colloids and Surfaces. B, Biointerfaces, 77(2), 139-149 (2010)
Edoardo Longo et al.
International journal of pharmaceutics, 480(1-2), 84-91 (2015-01-18)
Synchrotron radiation circular dichroism (SRCD) is a powerful tool for photo-stability assessment of proteins. Recently our research has been interested in applying SRCD to develop screening methodologies for accelerated photo-stability assessment of monoclonal antibody formulations. Despite it was proven to
1/3