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关键词:'A3782'
显示 31-60 共 69 条结果 关于 "A3782" 范围 论文
Simon Hauri et al.
Nature communications, 10(1), 192-192 (2019-01-16)
The understanding of complex biological systems is still hampered by limited knowledge of biologically relevant quaternary protein structures. Here, we demonstrate quaternary structure determination in biological samples using a combination of chemical cross-linking, high-resolution mass spectrometry and high-accuracy protein structure
Controlling adsorption of albumin with hyaluronan on silica surfaces and sulfonated latex particles.
Ida Berts et al.
Journal of colloid and interface science, 504, 315-324 (2017-05-30)
Polysaccharides are known to modify binding of proteins at interfaces and this paper describes studies of these interactions and how they are modified by pH. Specifically, the adsorption of human serum albumin on to polystyrene latex and to silica is
Robert T Wright et al.
European biophysics journal : EBJ (2018-07-14)
The goal of this work is to develop a preclinical method for quantitative hydrodynamic and thermodynamic analysis of therapeutic proteins in crowded environments like human serum. The method utilizes tracer amounts of fluorescently labeled monoclonal antibodies and the Aviv AU-FDS
M Morales et al.
Neuroscience, 152(1), 70-81 (2008-01-29)
The notion of functional interactions between the alpha7 nicotinic acetylcholine (alpha7 nACh) and the cannabinoid systems is emerging from recent in vitro and in vivo studies. Both the alpha7 nACh receptor and the cannabinoid receptor 1 (CB1) are highly expressed
Kotaro Suzuki et al.
Cell, 134(3), 485-495 (2008-08-12)
Mast cells are known to play a pivotal role in allergic diseases. Cross-linking of the high-affinity receptor for IgE (FcepsilonRI) leads to degranulation and allergic inflammation; however, the regulatory mechanisms of IgE-dependent exocytosis remain unknown. We show here that IkappaB
Ana Diniz et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 23(53), 13213-13220 (2017-06-27)
Protein-glycan interactions as modulators for quinary structures in crowding environments were explored. The interaction between human galectin 3 (Gal-3) and distinct macromolecular crowders, such as bovine and human serum albumin (BSA and HSA), Ficoll 70 and PEG3350, was scrutinized. The
Edjane R Dos Santos et al.
Journal of inorganic biochemistry, 182, 48-60 (2018-02-13)
Thirteen new ruthenium amino acid complexes were synthesized and characterized. They were obtained by the reaction of α-amino acids (AA) with [RuCl2(P-P)(N-N)], where P-P=1,4-bis(diphenylphosphino)butane (dppb) or 1,3-bis(diphenylphosphino)propane (dppp) and N-N=4,4'-dimethyl-2,2'-bipyridine (4'-Mebipy), 5,5'-dimethyl-2,2'-bipyridine (5'-Mebipy) or 4,4'-Methoxy-2-2'-bipyridine (4'-MeObipy). This afforded a family
Cristina P Matos et al.
Dalton transactions (Cambridge, England : 2003), 48(24), 8702-8716 (2019-05-28)
In the quest for therapeutic iron-based metallodrugs, two new mixed-ligand iron(iii) complexes bearing the tripodal aminobisphenolate ligand N,N-bis(3,5-dimethyl-2-hydroxybenzyl)-N-(2-pyridylmethyl)amine (H2L) and hydroxyquinoline co-ligands, 8-hydroxyquinoline (8HQ) or 5-chloro-8-hydroxyquinoline (Cl8HQ), are synthesized, fully characterized and formulated as [Fe(L)(8HQ)] (1) and [Fe(L)(Cl8HQ)] (2), respectively.
Fabricio Ragone et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 22(1), 99-108 (2016-11-07)
A new synthetic route to acquire the water soluble complex fac-Re
Chris Tran et al.
Science (New York, N.Y.), 324(5928), 787-790 (2009-04-11)
Metastatic prostate cancer is treated with drugs that antagonize androgen action, but most patients progress to a more aggressive form of the disease called castration-resistant prostate cancer, driven by elevated expression of the androgen receptor. Here we characterize the diarylthiohydantoins
Michael J Kimzey et al.
Toxicology and applied pharmacology, 289(2), 155-162 (2015-10-06)
Increasing evidence identifies dicarbonyl stress from reactive glucose metabolites, such as methylglyoxal (MG), as a major pathogenic link between hyperglycemia and complications of diabetes. MG covalently modifies arginine residues, yet the site specificity of this modification has not been thoroughly
Coordination ability and biological activity of a naringenin thiosemicarbazone.
Katarzyna Brodowska et al.
Journal of inorganic biochemistry, 165, 36-48 (2016-10-21)
Oxidative damage of albumin in advanced liver disease
Oettl K, et al.
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1782(7-8), 469-473 (2008)
Tânia S Morais et al.
Pharmaceuticals (Basel, Switzerland), 15(7) (2022-07-28)
Ruthenium complexes are emerging as one of the most promising classes of complexes for cancer therapy. However, their limited aqueous solubility may be the major limitation to their potential clinical application. In view and to contribute to the progress of
Eleonore Coppens et al.
International journal of pharmaceutics, 609, 121076-121076 (2021-09-06)
A simple approach to achieve a lipoprotein (LP)-mediated drug delivery is to trigger the spontaneous drug insertion into endogenous lipoproteins in the bloodstream, by means of its chemical modification. Nanoparticles (NPs) made of the squalene-gemcitabine (SQGem) conjugate were found to
Evelien Wynendaele et al.
RSC advances, 11(25), 15332-15339 (2022-04-16)
Although human serum albumin (HSA) has been used for many decades, there is still a lack of suitable quality control (QC) attributes. Its current use as a raw material in gene-, cell- and tissue-therapies requires more appropriate functionally-relevant quality attributes
Shuto Yokohata et al.
Microbiology and immunology, 67(2), 58-68 (2022-12-09)
Anginosus group streptococci (AGS) are opportunistic pathogens of the human oral cavity; however, their pathogenicity has not been discussed in detail. Oral streptococci live in the gingival sulcus, from where they can easily translocate into the bloodstream due to periodontal
Conan K Wang et al.
The Journal of biological chemistry, 295(34), 12143-12152 (2020-07-11)
Rapid clearance by renal filtration is a major impediment to the translation of small bioactive biologics into drugs. To extend serum t 1/2, a commonly used approach is to attach drug leads to the G-related albumin-binding domain (ABD) to bind
Naeimeh Jafari et al.
Journal of medicinal chemistry, 59(16), 7457-7465 (2016-07-19)
Human serum albumin (HSA) serves not only as a physiological oncotic pressure regulator and a ligand carrier but also as a biomarker for pathologies ranging from ischemia to diabetes. Moreover, HSA is a biopharmaceutical with a growing repertoire of putative
Sabina W Jaros et al.
Inorganic chemistry, 60(20), 15435-15444 (2021-09-22)
Coordination polymers have emerged as a new class of potent biologically active agents due to a variety of important characteristics such as the presence of bioactive metal centers and linkers, low toxicity, stability, tailorable structures, and bioavailability. The research on
Valeria I Raskolupova et al.
Molecules (Basel, Switzerland), 26(9) (2021-06-03)
BODIPY dyes are photostable neutral derivatives of 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene. These are widely used as chemosensors, laser materials, and molecular probes. At the same time, BODIPY dyes have small or moderate Stokes shifts like most other fluorophores. Large Stokes shifts are preferred
Pedro Palhari Santos et al.
Journal of biomaterials science. Polymer edition, 30(17), 1575-1590 (2019-07-30)
Polyglycerol dendrimer synthesized from glycerol core (PGLyD) is an interesting reservoir macromolecule for the design of drug delivery systems due to their adequate blood biocompatibility. However, important features as the comprehension of the structural and dynamic characteristics and the interactions
Yi Gou et al.
Molecular pharmaceutics, 14(6), 1861-1873 (2017-05-05)
We not only modified the types and numbers of coordinated ligands in a metal agent to enhance its anticancer activity, but we also designed a metal prodrug based on the N-donor residues of the human serum albumin (HSA) IIA subdomain
Peiqing Ying et al.
Journal of colloid and interface science, 279(1), 95-99 (2004-09-24)
Human serum albumin adsorption onto gold surfaces was investigated by electrochemical and ellipsometric methods. Albumin adsorption onto gold was confirmed by the change of the open circuit potential of gold and by the ellipsometric parameter variation during albumin immobilization. In
Yi Huang et al.
Archives of biochemistry and biophysics, 619, 54-61 (2017-03-21)
GAPDH was speculated to function as a transient trap to reduce the potential toxicity of free heme by a specific and reversible binding with heme. Up to now, there has been lack of studies focused on this effect. In this
Elena Guercia et al.
Food chemistry, 199, 502-508 (2016-01-19)
Cafestol and 16-O-methylcafestol are diterpenes present in coffee, but whilst cafestol is found in both Coffea canephora and Coffea arabica, 16-O-methylcafestol (16-OMC) was reported to be specific of only C. canephora. The interactions of such compounds, with serum albumins, have
Mei Li et al.
Chemical biology & drug design, 83(2), 167-173 (2013-09-17)
To investigate the interactions between natural drugs and human serum albumin (HSA), we performed fluorescence spectroscopy and X-ray crystallography to gain insight into binding mechanism and behaviour of rhein to HSA. Our fluorescence results demonstrated that rhein strongly binds with
Kisung Lee et al.
Journal of biomedical optics, 22(9), 91516-91516 (2017-06-22)
Red blood cell (RBC) aggregation is an intrinsic property of the blood that has a direct effect on the blood viscosity and circulation. Nevertheless, the mechanism behind the RBC aggregation has not been confirmed and is still under investigation with
Akitoshi Tatsumi et al.
Biological & pharmaceutical bulletin, 39(8), 1364-1369 (2016-08-02)
Human serum albumin (HSA) has two major ligand-binding sites, sites I and II, and also hydrolyzes some compounds at both sites. In the present study, we investigated differences in esterase activity among HSA preparations, and also the effects of warfarin
Gerhard Leinenga et al.
Science translational medicine, 7(278), 278ra33-278ra33 (2015-03-13)
Amyloid-β (Aβ) peptide has been implicated in the pathogenesis of Alzheimer's disease (AD). We present a nonpharmacological approach for removing Aβ and restoring memory function in a mouse model of AD in which Aβ is deposited in the brain. We
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