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关键词:'A5843'
显示 1-16 共 16 条结果 关于 "A5843" 范围 论文
Sam Coffey et al.
PloS one, 10(10), e0140417-e0140417 (2015-10-16)
Diabetes mellitus (DM) has become an epidemic, causing a significant decline in quality of life of individuals due to its multisystem involvement. Kidney is an important target organ in DM accounting for the majority of patients requiring renal replacement therapy
Audra A Winder et al.
Respiratory research, 10, 96-96 (2009-10-20)
The recognition of microbial molecular patterns via toll-like receptors (TLRs) is critical for mucosal defenses. Using well-differentiated primary cultures of human airway epithelia, we investigated the effects of exposure of the cells to cytokines (TNF-alpha and IFN-gamma) and dexamethasone (dex)
D Sevillano et al.
The Journal of antimicrobial chemotherapy, 60(1), 156-158 (2007-05-08)
Attempts to interpret antibiotic pharmacodynamics using reported protein binding may underestimate true activity. To elucidate this issue we examined bacterial killing kinetics at cefditoren concentrations equal to C(max) in the presence of 90% human serum or albumin at physiological concentrations.
Victor A McPherson et al.
Molecular and cellular biology, 29(2), 389-401 (2008-11-13)
This study investigates the roles of Fer-CIP4 homology (FCH)-Bin/amphiphysin/Rvs (F-BAR) and SH2 domains of Fes protein tyrosine kinase in regulating its activation and signaling downstream of the high-affinity immunoglobulin G (IgE) receptor (FcepsilonRI) in mast cells. Homology modeling of the
Harald Olsen et al.
BMC clinical pharmacology, 4, 4-4 (2004-03-30)
Albumin is the most abundant protein in blood plasma, and due to its ligand binding properties, serves as a circulating depot for endogenous and exogenous (e.g. drugs) compounds. Hence, the unbound drug is the pharmacologically active drug. Commercial human albumin
Stephanie K Aoki et al.
Molecular microbiology, 70(2), 323-340 (2008-09-03)
Contact-dependent growth inhibition (CDI) is a phenomenon by which bacterial cell growth is regulated by direct cell-to-cell contact via the CdiA/CdiB two-partner secretion system. Characterization of mutants resistant to CDI allowed us to identify BamA (YaeT) as the outer membrane
Zhenping Liu et al.
The review of diabetic studies : RDS, 5(4), 232-244 (2009-03-19)
The influence of glucose and fatty acids on beta-cell function is well established whereas little is known about the role of amino acids (AAs). Islets isolated from NMRI mice were incubated overnight. After preincubation, isolated islets as well as clonal
M Morales et al.
Neuroscience, 152(1), 70-81 (2008-01-29)
The notion of functional interactions between the alpha7 nicotinic acetylcholine (alpha7 nACh) and the cannabinoid systems is emerging from recent in vitro and in vivo studies. Both the alpha7 nACh receptor and the cannabinoid receptor 1 (CB1) are highly expressed
Kotaro Suzuki et al.
Cell, 134(3), 485-495 (2008-08-12)
Mast cells are known to play a pivotal role in allergic diseases. Cross-linking of the high-affinity receptor for IgE (FcepsilonRI) leads to degranulation and allergic inflammation; however, the regulatory mechanisms of IgE-dependent exocytosis remain unknown. We show here that IkappaB
Edina Korça et al.
Scientific reports, 10(1), 17105-17105 (2020-10-15)
Advanced glycation endproducts (AGEs) are formed in a series of non-enzymatic reactions between reducing sugars and the amino groups of proteins and accumulate during aging, diabetes mellitus, chronic kidney disease and other chronic diseases. Accumulation of AGE-modifications alters protein structure
Yasutaka Kuroda et al.
The Journal of toxicological sciences, 45(6), 327-337 (2020-06-05)
Hydrolyzed wheat proteins (HWPs) contained in cosmetics have occasionally caused immediate-type hypersensitivity following repeated skin exposure. Although the Cosmetic Ingredient Review Expert Panel concluded that < 3,500 Da HWP is safe for use in cosmetics, it remains biologically unknown how
Miranda J Ridder et al.
Infection and immunity, 88(8) (2020-06-10)
Staphylococcus aureus fatty acid kinase FakA is necessary for the incorporation of exogenous fatty acids into the lipid membrane. We previously demonstrated that the inactivation of fakA leads to decreased α-hemolysin (Hla) production but increased expression of the proteases SspAB
Nitin Agrawal et al.
Lab on a chip, 8(12), 2054-2061 (2008-11-22)
Neutrophil directional migration in response to chemical gradients, also known as chemotaxis, is one of the key phenomena in the immune responses against bacterial infection. To better study neutrophils chemotaxis, several in vitro assays have been developed that replicate chemotactic
Theresa J Pell et al.
SLAS discovery : advancing life sciences R & D, 26(7), 909-921 (2021-06-05)
A core aspect of epithelial cell function is barrier integrity. A loss of barrier integrity is a feature of a number of respiratory diseases, including asthma, allergic rhinitis, and chronic obstructive pulmonary disease. Restoration of barrier integrity is a target
Yasutaka Kuroda et al.
Journal of immunotoxicology, 14(1), 178-187 (2017-07-20)
A growing body of evidence suggests that epicutaneous sensitization of protein allergens induces immediate-type hypersensitivity (IHS) following induction of Type 2 immune responses in animals and humans. Thymic stromal lymphopoietin (TSLP) derived from keratinocytes is a cytokine that can activate
Elif Erkan et al.
Journal of the American Society of Nephrology : JASN, 18(4), 1199-1208 (2007-03-16)
Nephrotic-range proteinuria is considered a poor prognostic factor. A correlation between tubulointerstitial injury and the degree of proteinuria is well established. In an attempt to explain the tubular atrophy that is observed in advanced glomerulonephritides, this study investigated apoptotic mechanisms
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