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关键词:'C7017'
显示 1-30 共 185 条结果 关于 "C7017" 范围 论文
Brook T Chernet et al.
Oncotarget, 5(10), 3287-3306 (2014-05-17)
The microenvironment is increasingly recognized as a crucial aspect of cancer. In contrast and complement to the field's focus on biochemical factors and extracellular matrix, we characterize a novel aspect of host:tumor interaction - endogenous bioelectric signals among non-excitable somatic
Zhuo Li et al.
Biochimica et biophysica acta, 1840(7), 2112-2122 (2014-03-19)
Choline kinase has three isoforms encoded by the genes Chka and Chkb. Inactivation of Chka in mice results in embryonic lethality, whereas Chkb(-/-) mice display neonatal forelimb bone deformations. To understand the mechanisms underlying the bone deformations, we compared the
Maria G A Hägglund et al.
Journal of molecular biology, 427(6 Pt B), 1495-1512 (2014-12-03)
Glutamine transporters are important for regulating levels of glutamate and GABA in the brain. To date, six members of the SLC38 family (SNATs) have been characterized and functionally subdivided them into System A (SNAT1, SNAT2 and SNAT4) and System N
Tino Jaschinski et al.
Rapid communications in mass spectrometry : RCM, 28(13), 1521-1529 (2014-05-28)
Laser desorption ionization for mass spectrometric measurements (LDI MS) is supported by nanostructured materials. This technique helps to overcome known limitations of matrix-assisted laser desorption/ionization (MALDI) and especially avoids interfering signals caused by matrix components. LDI can be supported by
Eric M Prager et al.
Neurotoxicology, 44, 335-343 (2014-08-26)
The recent sarin attack in Syria killed 1429 people, including 426 children, and left countless more to deal with the health consequences of the exposure. Prior to the Syrian chemical assault, nerve agent attacks in Japan left many victims suffering
Eugen Brailoiu et al.
Cell reports, 26(2), 330-337 (2019-01-10)
Sigma-1 receptors (Sig-1Rs) are integral ER membrane proteins. They bind diverse ligands, including psychoactive drugs, and regulate many signaling proteins, including the inositol 1,4,5-trisphosphate receptors (IP3Rs) that release Ca2+ from the ER. The endogenous ligands of Sig-1Rs are unknown. Phospholipase
Artor Niccoli-Asabella et al.
Recenti progressi in medicina, 104(2), 73-75 (2013-03-29)
In a patient with cerebral gliomatosis type II MRI revealed a large area of altered signal in the temporal region, parietal and occipital lobes associated with a single nodule with perilesional contrast enhancement, which showed increased uptake on PET/CT with
Vignesh Thiagarajan et al.
Journal of colloid and interface science, 462, 334-340 (2015-10-18)
Choline, a type of Vitamin B, is an important nutrient in the human body and is involved in key metabolic pathways. Abnormal levels of choline leads to diseased conditions. The levels of choline and its associated compounds are found to
Alexandra Petruş et al.
Canadian journal of physiology and pharmacology, 93(9), 811-818 (2015-09-02)
A substantial body of evidence indicates that pharmacological activation of mitochondrial ATP-sensitive potassium channels (mKATP) in the heart is protective in conditions associated with ischemia/reperfusion injury. Several mechanisms have been postulated to be responsible for cardioprotection, including the modulation of
Dale A Fortin et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(50), 16698-16712 (2014-12-17)
Stoichiometric labeling of endogenous synaptic proteins for high-contrast live-cell imaging in brain tissue remains challenging. Here, we describe a conditional mouse genetic strategy termed endogenous labeling via exon duplication (ENABLED), which can be used to fluorescently label endogenous proteins with
Jacob C Nordman et al.
Journal of neurochemistry, 129(4), 649-662 (2013-12-20)
Cholinergic signaling plays an important role in regulating the growth and regeneration of axons in the nervous system. The α7 nicotinic receptor (α7) can drive synaptic development and plasticity in the hippocampus. Here, we show that activation of α7 significantly
J Li et al.
Clinical radiology, 70(1), 37-41 (2014-12-03)
To assess the role of proton MR spectroscopy (MRS) in the detection of changes in metabolite levels of the cerebellum after heat stroke (HS). The study group consisted of eight patients after HS, with a Glasgow Coma Scale (GCS) score
Marina Orevi et al.
Clinical nuclear medicine, 39(12), 1033-1038 (2014-10-08)
This prospective pilot study was aimed to evaluate ¹¹C-choline PET/CT (choline) as a tool for localization of parathyroid adenoma (PTA). Forty patients with biochemical hyperparathyroidism underwent choline and ⁹⁹mTc-MIBI imaging within a median interval of 56 days. Choline and MIBI
Benjamin Kolisnyk et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(37), 14908-14920 (2013-09-13)
One of the key brain regions in cognitive processing and executive function is the prefrontal cortex (PFC), which receives cholinergic input from basal forebrain cholinergic neurons. We evaluated the contribution of synaptically released acetylcholine (ACh) to executive function by genetically
Veronika Fischer et al.
Journal of colloid and interface science, 453, 186-193 (2015-05-20)
It was recently demonstrated that a nano-clustering was present in the monophasic "pre-Ouzo" region of ternary liquid mixtures without surfactants. The goal of this work is to check if this nano-clustering is also present in the surfactant-free and water-free "green"
Zienab Alrefaie et al.
Behavioural brain research, 287, 156-162 (2015-04-04)
Complications of diabetes mellitus include cognitive impairments and functional changes in the brain. The present study aimed to investigate the possible beneficial effect of vitamin D3 on episodic memory and cholinergic transmission in the prefrontal cortex of streptozotocin-induced diabetic rats.
Noorul Adawiyah Mustahil et al.
Chemosphere, 229, 349-357 (2019-05-13)
Ionic liquids (ILs) based surfactants have been emerged as attractive alternatives to the conventional surfactants owing to their tailor-made and eco-friendly properties. Therefore, present study described the synthesis of nine new fatty amino acids based IL surfactants utilizing lauroyl sarcosinate
Wei Liu et al.
Food chemistry, 281, 140-146 (2019-01-20)
For simultaneous determination of lignans (i.e. sesamin, sesamolin and sesamol) in sesame oils, a highly efficient ultrasonic-assisted liquid-liquid microextraction (UALLME) technique was developed based on deep eutectic solvents (DESs) composed of choline chloride and p-cresol. Compared with the common polyols-based
Prevention of schizophrenia: an impossible dream?
Judith L Rapoport
The American journal of psychiatry, 170(3), 245-247 (2013-03-02)
Werner J Geldenhuys et al.
Bioorganic & medicinal chemistry letters, 20(16), 4870-4877 (2010-07-20)
The high affinity neuronal choline transporter (CHT1) is responsible for the uptake of choline into the pre-synaptic terminal of cholinergic neurons. Considering our past experience with modeling the blood-brain barrier choline transporter (BBBCHT) as drug delivery vector to the CNS
Agnieszka Zdybicka-Barabas et al.
Biochimica et biophysica acta, 1838(10), 2689-2697 (2014-07-13)
The greater wax moth Galleria mellonella has been exploited worldwide as an alternative model host for studying pathogenicity and virulence factors of different pathogens, including Legionella pneumophila, a causative agent of a severe form of pneumonia called Legionnaires' disease. An
Martine R Groen et al.
Journal of neurophysiology, 112(2), 287-299 (2014-04-25)
Synaptic plasticity rules change during development: while hippocampal synapses can be potentiated by a single action potential pairing protocol in young neurons, mature neurons require burst firing to induce synaptic potentiation. An essential component for spike timing-dependent plasticity is the
L Martin et al.
Oncogene, 34(32), 4211-4218 (2014-11-18)
SLC7A11 encodes a subunit of the xCT cystine/glutamate amino-acid transport system and has a critical role in the generation of glutathione and the protection of cells from oxidative stress. Expression of SLC7A11 promotes tumorigenesis and chemotherapy resistance, but while SLC7A11
Ayano Takeuchi-Yorimoto et al.
Toxicology and applied pharmacology, 268(3), 264-277 (2013-03-14)
Nonalcoholic steatohepatitis (NASH) is characterized by combined pathology of steatosis, lobular inflammation, fibrosis, and hepatocellular degeneration, with systemic symptoms of diabetes or hyperlipidemia, all in the absence of alcohol abuse. Given the therapeutic importance and conflicting findings regarding the potential
Kerry-Ann da Costa et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(7), 2970-2978 (2014-03-29)
Effect alleles (alleles with a polymorphism that is associated with the effect being measured) in a small number of single-nucleotide polymorphisms (SNPs) are known to influence the dietary requirement for choline. In this study, we examined a much larger number
Akiko Mizuno-Yasuhira et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(9), 1456-1465 (2014-07-10)
A strategy for assessing potential drug-drug interactions (DDIs) based on a simulated intestinal concentration is described. The proposed prediction method was applied to the DDI assessment of luseogliflozin, a novel antidiabetic drug, against miglitol absorbed via the intestinal sodium-glucose cotransporter
Soraia Poloni et al.
Gene, 546(2), 443-447 (2014-05-13)
Classical homocystinuria is a rare genetic disease caused by cystathionine β-synthase deficiency, resulting in homocysteine accumulation. Growing evidence suggests that reduced fat mass in patients with classical homocystinuria may be associated with alterations in choline and homocysteine pathways. This study
Andreas Hecker et al.
Journal of immunology (Baltimore, Md. : 1950), 195(5), 2325-2334 (2015-07-24)
IL-1β is a potent proinflammatory cytokine of the innate immune system that is involved in host defense against infection. However, increased production of IL-1β plays a pathogenic role in various inflammatory diseases, such as rheumatoid arthritis, gout, sepsis, stroke, and
Kim M Yonemori et al.
The Journal of nutrition, 143(6), 894-899 (2013-04-26)
Choline and betaine are important nutrients for human health, but reference food composition databases for these nutrients became available only recently. We tested the feasibility of using these databases to estimate dietary choline and betaine intakes among ethnically diverse adults
Durgesh V Wagle et al.
The journal of physical chemistry letters, 6(15), 2924-2928 (2015-08-13)
From macroscopic measurements of deep eutectic solvents such as glyceline (1:2 molar ratio of choline chloride to glycerol), the long-range translational diffusion of the larger cation (choline) is known to be slower compared to that of the smaller hydrogen bond
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