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Nicholas A McKeag et al.
JACC. Heart failure, 2(3), 308-317 (2014-06-24)
This study sought to investigate the effect of a multiple micronutrient supplement on left ventricular ejection fraction (LVEF) in patients with heart failure. Observational studies suggest that patients with heart failure have reduced intake and lower concentrations of a number
Hataikarn Nimitphong et al.
Nutrition journal, 12, 39-39 (2013-04-06)
It is not known whether genetic variation in the vitamin D binding protein (DBP) influences 25-hydroxyvitamin D levels [25(OH)D] after vitamin D supplementation. We aimed to investigate the changes of total 25(OH)D, 25(OH)D₃ and 25(OH)D₂ in a Thai cohort, according
Joan Hui Juan Lim et al.
The Journal of infectious diseases, 212(4), 635-644 (2015-01-24)
Vitamin D level is linked to susceptibility to infections, but its relevance in candidemia is unknown. We aimed to investigate the in vivo sequelae of vitamin D3 supplementation in systemic Candida infection. Implicating the role of vitamin D in Candida
Maria J Ramalho et al.
Beilstein journal of nanotechnology, 6, 1306-1318 (2015-07-23)
Poly(lactic-co-glycolic acid) (PLGA) nanoparticles were studied as drug delivery vehicles for calcitriol, the active form of vitamin D3. In vitro effects of calcitriol encapsulated in PLGA nanoparticles were evaluated with respect to free calcitriol on human pancreatic cell lines, S2-013
Laura A Nelson et al.
Neuroscience letters, 591, 171-175 (2015-02-15)
In mammalian models it is well documented that the potent orexigenic factor, neuropeptide Y (NPY) causes preferential intake of high carbohydrate and fat diets; however, information on this is limited in non-mammalian species. The purpose of this study was to
Bing Li et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 35(2), 433-440 (2015-01-24)
Transplantation of mesenchymal stem cells (MSCs) has therapeutic effects on various diseases, while its effect on developing cirrhosis as well as the underlying mechanism remained largely unknown. Twenty C57BL/6 mice were randomly separated into 2 groups of ten each. One
Clinical Veterinary Toxicology, 448-448 (2003)
Maria Eduarda L Diogenes et al.
The American journal of clinical nutrition, 98(1), 82-91 (2013-05-31)
Pregnancy and lactation in adolescents with habitually low calcium intake may adversely affect maternal bone mass. We investigated the effect of calcium plus vitamin D supplementation during pregnancy on bone mass during lactation in Brazilian adolescent mothers with low-calcium diets
Methap Yurt et al.
American journal of physiology. Lung cellular and molecular physiology, 307(11), L859-L867 (2014-10-12)
Whereas epidemiological data strongly link vitamin D (VD) deficiency to childhood asthma, the underlying molecular mechanisms remain unknown. Although VD is known to stimulate alveolar epithelial-mesenchymal interactions, promoting perinatal lung maturation, whether VD supplementation during this period protects against childhood
Kevin D Cashman et al.
The Journal of nutrition, 144(7), 1050-1057 (2014-05-16)
Fundamental knowledge gaps in relation to the 3 epimer of 25-hydroxycholecalciferol [3-epi-25(OH)D₃] limit our understanding of its relevance for vitamin D nutrition and health. The aims of this study were to characterize the 3-epi-25(OH)D₃ concentrations in a nationally representative sample
Lynn Kane et al.
The Journal of clinical endocrinology and metabolism, 98(11), 4400-4409 (2013-09-14)
Inverse associations between 25-OH vitamin D levels and cardiovascular morbidity and mortality have been reported. Our goals were to 1) investigate effects of correcting inadequate D status on lipids, 2) determine whether free 25-OH D is better correlated with lipids
Mariana Costa Silva et al.
Bone, 81, 338-342 (2015-07-26)
Oral supplements are important to prevent and treat vitamin D deficiency. Despite the growing number of prescriptions, vitamin D's absorptive mechanisms are not clearly elucidated. By evaluating the effect of ezetimibe on vitamin D absorption, we aim to determine if
Yuko Murakami et al.
Microbes and infection, 16(2), 114-122 (2013-11-02)
Using a high-throughput screening system involving HCV JFH-1-Huh 7.5.1 cells, we determined that the ligands of class II nuclear receptors, retinoids and rexinoids inhibit HCV infection. Retinoids, ligands of retinoic acid receptor (RAR), and rexinoids, ligands of retinoid X receptor
Lara Coelho et al.
Nutrition journal, 14, 81-81 (2015-08-19)
HIV infection and antiretroviral therapy (ART) may create unique risk factors for vitamin D insufficiency, including alterations of vitamin D metabolism by ART. We prospectively compared demographic and clinical parameters between vitamin D sufficient and insufficient HIV-infected (HIV+) adults, and
Ming Kong et al.
American journal of physiology. Gastrointestinal and liver physiology, 307(9), G883-G893 (2014-09-13)
Vitamin D deficiency (VDD) or insufficiency is recognized for its association with nonalcoholic steatohepatitis (NASH), whereas the underlying mechanism remains unknown. Using animal models, we found that vitamin D deficiency promoted the high-fat diet (HFD)-initiated simple steatosis into typical NASH
Wenyi Qin et al.
Anticancer research, 33(9), 3861-3866 (2013-09-12)
Preclinical studies suggest that 1,25-dihydroxyvitamin D [1,25(OH)2D] and celecoxib inhibit prostaglandins (PGs) associated with cancer through different mechanisms. We determined if there was synergy in their use. A total of 36 healthy women received daily for one month/menstrual cycle: placebo
Bassem Refaat et al.
Journal of experimental & clinical cancer research : CR, 34, 71-71 (2015-07-25)
Vitamin D3 and its analogues have recently been shown to enhance the anti-tumour effects of 5- Fluorouracil (5-FU) both in vitro and in xenograft mouse model of colon cancer. This study measured the potential mechanism(s) by which vitamin D3 could
Alexander Holderied et al.
Laboratory investigation; a journal of technical methods and pathology, 95(3), 273-282 (2014-12-23)
The metabolic and hemodynamic alterations in diabetes activate podocytes to increase extracellular matrix (ECM) production, leading to thickening of the glomerular basement membrane (GBM). We hypothesized that diabetes would activate parietal epithelial cells (PECs) in a similar manner and cause
A H Perera et al.
Annals of the Royal College of Surgeons of England, 96(4), 284-288 (2014-05-02)
The main barriers to short stay thyroidectomy are haemorrhage, bilateral recurrent laryngeal nerve palsy causing respiratory compromise and hypocalcaemia. This study assessed the safety and effectiveness of thyroidectomy as a 23-hour stay procedure. All patients undergoing total or completion thyroidectomy
Tatiane Vilaça et al.
European journal of endocrinology, 170(4), 469-475 (2014-01-08)
Strontium ranelate is used to treat osteoporosis. Calcium (Ca) and strontium (Sr) have common chemical features and are absorbed by the same pathways. Vitamin D has a main role in calcium intestinal absorption. The aim of this study was to
D Hamam et al.
Cell death & disease, 5, e1499-e1499 (2014-10-31)
The molecular mechanisms promoting lineage-specific commitment of human mesenchymal (skeletal or stromal) stem cells (hMSCs) into adipocytes (ADs) are not fully understood. Thus, we performed global microRNA (miRNA) and gene expression profiling during adipocytic differentiation of hMSC, and utilized bioinformatics
Lei Wang et al.
The Journal of investigative dermatology, 135(8), 2102-2108 (2015-04-01)
Cutaneous T-cell lymphoma (CTCL) is a heterogeneous group of malignancies characterized by accumulation of malignant T-cells within the skin. Retinoids, metabolic derivatives, and synthetic analogs of vitamin A embody an effective CTCL therapy with over three decades of clinical use.
Jamal S Lewis et al.
Clinical immunology (Orlando, Fla.), 160(1), 90-102 (2015-04-07)
We developed a novel poly(lactic-co-glycolic acid)-based, microparticle (MP) system providing concurrent delivery of multiple encapsulated immuno-suppressive factors and antigen, for in vivo conditioning of dendritic cells (DCs) toward a tolerance promoting pathway. Subcutaneous administration prevents onset of type 1 diabetes
Andy Rorie et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 112(4), 376-382 (2014-02-11)
Observational reports have linked vitamin D with chronic urticaria, yet no randomized controlled trial has been conducted. To determine whether high-dose vitamin D supplementation would decrease Urticaria Symptom Severity (USS) scores and medication burden in patients with chronic urticaria. In
Chenchen Zhou et al.
Oral surgery, oral medicine, oral pathology and oral radiology, 114(5 Suppl), S174-S178 (2013-04-10)
This study aimed to investigate the effects of 1,25(OH)(2)D(3) on implant osseointegration in osteoporotic rats. Twelve weeks after bilateral ovariectomy, each rat had 2 titanium screws implanted in the proximal tibiae. All animals were then randomly divided into 2 groups:
Basavraj Sooragonda et al.
Acta haematologica, 133(1), 31-35 (2014-07-12)
The effect of vitamin D replacement on hemoglobin (Hb) concentration in subjects with concurrent deficiencies of vitamin D and iron is not known. We report on an investigator-initiated, randomized, single-blinded, placebo-controlled, 12-week interventional trial. Thirty subjects with iron-deficiency anemia (serum
Cristian Dima et al.
Food chemistry, 303, 125416-125416 (2019-09-01)
Calcium and vitamin D3 were co-encapsulated in three types of water-in-oil-in-water (W/O/W) double emulsions stabilized with biopolymers: gum arabic, sodium alginate (Alg) and chitosan (Ch). Three calcium salts with different solubility were used: calcium carbonate (CaC), tricalcium phosphate (CaP) and
Robert Scragg et al.
Hypertension (Dallas, Tex. : 1979), 64(4), 725-730 (2014-07-02)
Previous randomized controlled trials of vitamin D supplementation and blood pressure (BP) mainly have given vitamin D for short periods (<6 months) or at low doses (400 IU per day). This study aims to determine whether long-term high-dose vitamin D
Gabriella Masszi et al.
Life sciences, 93(4), 133-138 (2013-05-21)
In polycystic ovary syndrome (PCOS), metabolic and cardiovascular dysfunction is related to hyperandrogenic status and insulin resistance, however, Vitamin D3 has a beneficial effect partly due to its anti-oxidant capacity. Nitrative stress is a major factor in the development of
Xiaocang Cao et al.
The international journal of biochemistry & cell biology, 53, 372-379 (2014-06-11)
Alleviation of hyperglycemia in chemical-induced diabetic mice has been reported after bone marrow transplantation. Nevertheless, the underlying mechanism remains elusive. In the present study, we transplanted genetically labeled primary mouse mesenchymal stem cells into the pancreas of the streptozotocin-treated hyperglycemic
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