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Jean E Copper et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 208, 38-46 (2017-11-22)
In recognition of the importance of zebrafish as a model organism for studying human disease, we have created zebrafish content for a web-based reference atlas of microanatomy for comparing histology and histopathology between model systems and with humans (http://bio-atlas.psu.edu). Fixation
Yuki Matsushiro et al.
Biotechnology and bioengineering, 115(6), 1614-1623 (2018-02-11)
This paper describes three-dimensional (3D) tissue shape control of mouse neural stem cell (mNSC) micro tissues by using closed agarose microchambers for effective differentiation induction of neurons in vitro. Our agarose microchambers, made by micromolding, can be sealed with an
Catrin Youssif et al.
EMBO molecular medicine, 10(7) (2018-06-17)
The protein kinase p38α plays a key role in cell homeostasis, and p38α signaling in intestinal epithelial cells protects against colitis-induced tumorigenesis. However, little is known on the contribution of p38α signaling in intestinal stromal cells. Here, we show that
Mihaela Balas et al.
Nanomaterials (Basel, Switzerland), 8(7) (2018-07-07)
Magnetic nanoparticles offer multiple utilization possibilities in biomedicine. In this context, the interaction with cellular structures and their biological effects need to be understood and controlled for clinical safety. New magnetic nanoparticles containing metallic/carbidic iron and elemental silicon phases were
Manal Fardoun et al.
Biomolecules, 9(11) (2019-11-14)
Remodeling of arterioles is a pivotal event in the manifestation of many inflammation-based cardio-vasculopathologies, such as hypertension. During these remodeling events, vascular smooth muscle cells (VSMCs) switch from a contractile to a synthetic phenotype. The latter is characterized by increased
Marjan Nabili et al.
Ultrasound in medicine & biology, 39(4), 638-646 (2013-02-19)
Delivery of sufficient amounts of therapeutic drugs into the eye is often a challenging task. In this study, ultrasound application (frequencies of 400 KHz to 1 MHz, intensities of 0.3-1.0 W/cm(2) and exposure duration of 5 min) was investigated to overcome
Robert A Gaultney et al.
Nucleic acids research, 48(21), 12102-12115 (2020-12-11)
In bacteria, DNA methylation can be facilitated by 'orphan' DNA methyltransferases lacking cognate restriction endonucleases, but whether and how these enzymes control key cellular processes are poorly understood. The effects of a specific modification, 4-methylcytosine (4mC), are even less clear
Steven McFarlane et al.
PLoS pathogens, 15(3), e1007667-e1007667 (2019-03-23)
Host innate immune defences play a critical role in restricting the intracellular propagation and pathogenesis of invading viral pathogens. Here we show that the histone H3.3 chaperone HIRA (histone cell cycle regulator) associates with promyelocytic leukaemia nuclear bodies (PML-NBs) to
Mariafrancesca Cascione et al.
International journal of molecular sciences, 20(14) (2019-07-26)
The side effects induced by nanoparticle exposure at a cellular level are one of the priority research topics due to the steady increase in the use of nanoparticles (NPs). Recently, the focus on cellular morphology and mechanical behavior is gaining
Fumie Hamano et al.
Bio-protocol, 10(9), e3613-e3613 (2021-03-05)
In mammalian organisms, fatty acids (FAs) exist mostly in esterified forms, as building blocks of phospholipids, triglycerides, and cholesteryl esters, while some exist as non-esterified free FAs. The absolute quantification of FA species in total lipids or in a specific
Maxime Vermeulen et al.
International journal of molecular sciences, 20(21) (2019-11-07)
Cryopreservation of immature testicular tissue (ITT) prior to chemo/radiotherapy is now ethically accepted and is currently the only way to preserve fertility of prepubertal boys about to undergo cancer therapies. So far, three-dimensional culture of testicular cells isolated from prepubertal
B Sterner et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 101, 126-136 (2016-02-16)
The treatment of joint related diseases often involves direct intra-articular injections. For rational development of novel delivery systems with extended residence time in the joint, detailed understanding of transport and retention phenomena within the joint is mandatory. This work presents
Alexandre Super et al.
Biotechnology journal, 11(9), 1179-1189 (2016-05-24)
Oxygen plays a key role in stem cell biology as a signaling molecule and as an indicator of cell energy metabolism. Quantification of cellular oxygen kinetics, i.e. the determination of specific oxygen uptake rates (sOURs), is routinely used to understand
Marie-Lena I E Harwardt et al.
FEBS open bio, 7(9), 1422-1440 (2017-09-15)
The human MET receptor tyrosine kinase contributes to vertebrate development and cell proliferation. As a proto-oncogene, it is a target in cancer therapies. MET is also relevant for bacterial infection by
Yajie Zhang et al.
Pharmaceutics, 12(1) (2019-12-28)
Developing multifunctional and biocompatible drug delivery nanoplatforms that integrate high drug loads and multiple imaging modalities avoiding cross-interferences is extremely challenging. Here we report on the successful chemical reaction of the high quantum yield biodegradable and photoluminescent polyester (BPLP) with
Pierre-Michaël Coly et al.
Autophagy, 12(12), 2344-2362 (2016-10-30)
Chemotactic migration is a fundamental behavior of cells and its regulation is particularly relevant in physiological processes such as organogenesis and angiogenesis, as well as in pathological processes such as tumor metastasis. The majority of chemotactic stimuli activate cell surface
Jessica Z Kubicek-Sutherland et al.
Scientific reports, 9(1), 6203-6203 (2019-04-19)
Bacteremia is a leading cause of death in sub-Saharan Africa where childhood mortality rates are the highest in the world. The early diagnosis of bacteremia and initiation of treatment saves lives, especially in high-disease burden areas. However, diagnosing bacteremia is
Stephanie Saul et al.
Journal of leukocyte biology, 106(5), 1101-1115 (2019-06-20)
Neutrophils play a central role in immunity and inflammation via their intrinsic ability to migrate into inflamed tissue, to phagocytose pathogens, and to kill bacterial and fungi by releasing large quantities of superoxide anions and lytic enzymes. The molecular pathways
Germán Belenguer et al.
STAR protocols, 2(2), 100425-100425 (2021-04-27)
This protocol provides a flow-cytometry-based procedure to classify and isolate all cells of the adult rodent subependymal zone (SEZ) neurogenic lineage, without the need for reporter mice, into different cell populations, including three neural stem cell (NSC) fractions with molecular
Mira Oswald et al.
International journal of pharmaceutics, 497(1-2), 293-300 (2015-11-17)
Functionalized phospholipids are indispensable materials for the design of targeted liposomes. Control over the quality and quantity of phospholipids is thereby key in the successful development and manufacture of such formulations. This was also the case for a complex liposomal
Marie-Lena I E Harwardt et al.
International journal of molecular sciences, 21(8) (2020-04-23)
Receptor tyrosine kinases (RTKs) orchestrate cell motility and differentiation. Deregulated RTKs may promote cancer and are prime targets for specific inhibitors. Increasing evidence indicates that resistance to inhibitor treatment involves receptor cross-interactions circumventing inhibition of one RTK by activating alternative
Frank Klont et al.
Talanta, 182, 414-421 (2018-03-05)
The study of proteins is central to unraveling (patho)physiological processes and has contributed greatly to our understanding of biological systems. Corresponding studies often employ procedures to enrich proteins from their biological matrix using antibodies or other affinity binders coupled to
Frank Klont et al.
Talanta, 202, 507-513 (2019-06-07)
Quantification of intact proteins in complex biological matrices by liquid chromatography-mass spectrometry (LC-MS) is a promising analytical strategy but is technically challenging, notably for concentrations at or below the ng/mL level. Therefore, MS-based protein quantification is mostly based on measuring
Manal M Fardoun et al.
Vascular pharmacology, 131, 106690-106690 (2020-05-15)
Cutaneous cold-induced vasoconstriction is a normal physiological reaction mediated by alpha 2C-adrenergic receptors (α2C-ARs) expressed in vascular smooth muscle cells (VSMCs). When this reaction is exaggerated, Raynaud's phenomenon (RP) ensues. RP is more prevalent in females compared to age-matched men.
Florian Larramendy et al.
Lab on a chip, 19(5), 875-884 (2019-02-07)
This paper addresses a nanoengineering approach to create a fully three-dimensional (3D) network of living cells, providing an advanced solution to in vitro studies on either neuronal networks or artificial organs. The concept of our work relies on stackable scaffolds
Frank Klont et al.
Journal of proteome research, 17(8), 2892-2899 (2018-07-15)
Antibodies are indispensable tools in biomedical research, but their size, complexity, and sometimes lack of reproducibility created a need for the development of alternative binders to overcome these limitations. Affimers are a novel class of affinity binders based on a
Nicolás E Muzzio et al.
Materials science & engineering. C, Materials for biological applications, 80, 677-687 (2017-09-04)
The development of antifouling coatings with restricted cell and bacteria adherence is fundamental for many biomedical applications. A strategy for the fabrication of antifouling coatings based on the layer-by-layer assembly and thermal annealing is presented. Polyelectrolyte multilayers (PEMs) assembled from
Nicolás E Muzzio et al.
Biomaterials science, 6(8), 2230-2247 (2018-07-07)
The modulation of cell adhesion via biologically inspired materials plays a key role in the development of realistic platforms to envisage not only mechanistic descriptions of many physiological and pathological processes but also new biointerfacial designs compatible with the requirements
A D Cabral et al.
The Analyst, 142(20), 3922-3933 (2017-09-21)
Chemosensors for the detection of phosphate-containing biological species are in high need. Detection of proximally phosphorylated sites of PP
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