CN
Search Within
D1530
应用筛选条件
关键词:'D1530'
显示 1-30 共 258 条结果 关于 "D1530" 范围 论文
Hitoshi Saito et al.
The Journal of steroid biochemistry and molecular biology, 144 Pt A, 189-196 (2013-12-03)
Calcitriol (1α,25-dihydroxyvitamin D3, 1α,25(OH)2D3) is an essential hormone that works in cooperation with parathyroid hormone (PTH) and fibroblast growth factor-23 (FGF-23) to regulate calcium and phosphorus homeostasis. Previous in vivo studies in rats have shown that eldecalcitol, a vitamin D
L E Mallette
The American journal of the medical sciences, 304(1), 32-37 (1992-07-01)
For 18 years, a patient with idiopathic hypoparathyroidism has experienced stiffness or tetany chiefly at the time of menses. A significant decline (0.2 mmol/L) in her serum total and ionized calcium values was observed after the withdrawal of oral contraceptive
Rafal Barycki et al.
Bioorganic & medicinal chemistry, 17(22), 7658-7669 (2009-10-13)
The 18-nor (7), 21-nor (8) and 18,21-dinor (9) analogs of (20S)-1alpha,25-dihydroxy-2-methylene-19-norvitamin D(3) (6, 2MD) were prepared by convergent syntheses. The known phosphine oxide 10 was coupled by the Wittig-Horner process with the corresponding C,D-fragments (13-15), obtained by a multi-step procedure
Luis F de Castro et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 34(2), 290-294 (2018-11-30)
Fibrous dysplasia of bone (FD) is a mosaic disease caused by mutations in GNAS. Constitutive activation of the α-subunit of the Gs stimulatory protein (Gαs) leads to dysregulated proliferation of bone marrow stromal cells (BMSCs), generating expansile lesions of fibrotic
Fahimeh Varzideh et al.
Biomaterials, 192, 537-550 (2018-12-12)
Human cardiomyocytes (CM) differentiated from pluripotent stem cells (PSCs) are relatively immature when generated in two-dimensional (2D) in vitro cultures, which limits their biomedical applications. Here, we devised a strategy to enhance maturation of human CM in vitro by assembly
Lopa M Das et al.
Autophagy, 15(5), 813-826 (2019-01-22)
Cutaneous inflammation from UV radiation exposure causes epidermal damage, cellular infiltration, and secretion of pro-inflammatory mediators that exacerbate tissue destruction. Recovery is mediated chiefly by anti-inflammatory M2 macrophages that suppress inflammation and augment epidermal regeneration. Vitamin D enables anti-inflammation to
Rewa Verma et al.
The Journal of steroid biochemistry and molecular biology, 141, 1-6 (2014-01-01)
In humans, there are ten Toll-like receptors (TLRs), among which TLR10 is the only orphan receptor whose function is unknown. In this study, we examined the effects of IFN-γ, LPS and 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] on TLR10 expression of human monocyte
D Umlauf et al.
Deutsche medizinische Wochenschrift (1946), 139(4), 134-138 (2014-01-17)
A 92-year-old woman was admitted because her general condition had deteriorated during the last two weeks and acute kidney injury had developed. Moreover, she suffered from periods of disorientation and confusion while heretofore she was autonomous. INVESTIGATION, TREATMENT AND COURSE:
Sylvia Christakos et al.
Endocrinology, 152(8), 2930-2936 (2011-06-16)
In recent years, vitamin D has received increased attention due to the resurgence of vitamin D deficiency and rickets in developed countries together with the identification of extraskeletal vitamin D receptor-mediated actions, suggesting unexpected benefits of vitamin D in health
Andrew J Annalora et al.
Toxicology and applied pharmacology, 364, 55-67 (2018-12-16)
Alternative splicing modulates gene function by creating splice variants with alternate functions or non-coding RNA activity. Naturally occurring variants of nuclear receptor (NR) genes with dominant negative or gain-of-function phenotypes have been documented, but their cellular roles, regulation, and responsiveness
I Bhan et al.
Kidney international, 70(8), 1486-1494 (2006-08-31)
Hypophosphatemia is a common complication of kidney transplantation. Tertiary hyperparathyroidism has long been thought to be the etiology, but hypophosphatemia can occur despite low parathyroid hormone (PTH) levels and can persist after high PTH levels normalize. Furthermore, even in the
Denis Fourches et al.
Chemical research in toxicology, 23(1), 171-183 (2009-12-18)
Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this
A Gurlek et al.
Critical reviews in eukaryotic gene expression, 11(4), 299-317 (2002-06-18)
Osteoblast growth and differentiation encompass a series of events including proliferation, changes in cell shape, and expression of the markers specific for osteoblast phenotype. Both transforming growth factor-beta (TGF-beta) and 1alpha,25-dihydroxyvitamin D3 (1alpha,25[OH]2D3) are effective in regulating osteoblast proliferation, differentiation
Declan Doherty et al.
The Prostate, 74(3), 273-285 (2013-11-19)
A contributing factor to the emergence of castrate resistant prostate cancer (CRPC) is the ability of the tumor to circumvent low circulating levels of testosterone during androgen deprivation therapy (ADT), through the production of "intracrine" tumoral androgens from precursors including
Sungsin Jo et al.
BMB reports, 52(6), 391-396 (2018-10-26)
Receptor activator of nuclear factor kappa B ligand (RANKL) expression in osteoblasts is regulated by 1,25-dihydroxyvitamin D3 (1,25D3). CCAAT/enhancer-binding protein beta (C/EBPβ) has been proposed to function as a transcription factor and upregulate RANKL expression, but it is still uncertain
Francesca Tentori et al.
Clinical journal of the American Society of Nephrology : CJASN, 10(1), 98-109 (2014-12-18)
Elevated parathyroid hormone levels may be associated with adverse clinical outcomes in patients on dialysis. After the introduction of practice guidelines suggesting higher parathyroid hormone targets than those previously recommended, changes in parathyroid hormone levels and treatment regimens over time
Junichi Kikuta et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(17), 7009-7013 (2013-04-10)
The migration and positioning of osteoclast precursor monocytes are controlled by the blood-enriched lipid mediator sphingosine-1-phosphate (S1P) and have recently been shown to be critical points of control in osteoclastogenesis and bone homeostasis. Here, we show that calcitriol, which is
Marc Lamblin et al.
Bioorganic & medicinal chemistry, 18(11), 4119-4137 (2010-05-11)
Incorporation of zinc-binding groups into the side-chain of 1alpha,25-dihydroxyvitamin D(3) (1,25D) fully bifunctional hybrid molecules which act both as vitamin D receptor agonists and histone deacetylase inhibitors. These bifunctional hybrids display in vitro antiproliferative activity against the AT84 squamous carcinoma
Kazuki Shimizu et al.
Bioorganic & medicinal chemistry letters, 16(12), 3323-3329 (2006-04-25)
Design, synthesis, and in vitro and in vivo evaluation of a series of antipsoriatic antedrugs having 16-en-22-oxa-vitamin D3 are described. Among the seven compounds examined, two are promising: ester 5c and amide 5f, both of which exhibit greater potent antiproliferation
Mariko Takami et al.
Journal of immunology (Baltimore, Md. : 1950), 195(6), 2520-2523 (2015-08-16)
The immunoregulatory functions of vitamin D have been well documented in various immunological disorders, including multiple sclerosis, arthritis, and asthma. IL-10 is considered a chief effector molecule that promotes the vitamin D-induced immunosuppressive states of T cells and accessory cells.
Vitamin D deficiency reduces the benefits of progesterone treatment after brain injury in aged rats.
Milos Cekic et al.
Neurobiology of aging, 32(5), 864-874 (2009-06-02)
Administration of the neurosteroid progesterone (PROG) has been shown to be beneficial in a number of brain injury models and in two recent clinical trials. Given widespread vitamin D deficiency and increasing traumatic brain injuries (TBIs) in the elderly, we
Status of research on vitamin D supplementation in treating or preventing liver fibrosis.
Byoung-Joon Song et al.
Liver international : official journal of the International Association for the Study of the Liver, 33(5), 653-655 (2013-04-09)
Rafal R Sicinski et al.
Journal of medicinal chemistry, 50(24), 6154-6164 (2007-10-27)
To establish the conformation of vitamin D compounds responsible for biological activity, a 1alpha,25-dihydroxy-19-norvitamin D analogue 4 possessing a 1alpha-hydroxy group fixed in the axial orientation (beta-chair form) was synthesized. The starting compounds were bicyclic lactones 6, 7a, and 7b
Bo Li et al.
PloS one, 8(3), e58808-e58808 (2013-03-22)
1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) suppresses autoimmunity and inflammation; however, the mechanism of its action has not been fully understood. We sought in this study to determine whether the anti-immune/anti-inflammatory action of 1,25(OH)2D3 is in part mediated through an interplay between 1,25(OH)2D3
Ali Halhali et al.
The Journal of steroid biochemistry and molecular biology, 144 Pt A, 44-49 (2014-01-01)
Placenta is an extrarenal source of calcitriol and pregnancy is associated with increased maternal serum levels of this hormone. It has been reported that insulin-like growth factor I (IGF-I) stimulates placental calcitriol synthesis and that circulating levels of both hormones
Masato Shimizu et al.
Bioorganic & medicinal chemistry, 16(14), 6949-6964 (2008-06-10)
Recently, we have found that 16-ene-22-thia-26,27-dimethyl-19-norvitamin D(3) analogs 1a (n=2, 3) are 20 times more active than the natural hormone 1alpha,25-dihydroxyvitamin D(3) in terms of transcriptional activity. To further investigate the effects of the A-ring modification of 1a, b on
Efficacy and safety of calcipotriol/betamethasone dipropionate ointment for the treatment of simple onycholysis: an open-label study.
Jung-Min Park et al.
Journal of the American Academy of Dermatology, 69(3), 492-493 (2013-08-21)
Wataru Hakamata et al.
Bioorganic & medicinal chemistry letters, 18(1), 120-123 (2007-12-07)
Vitamin D receptor (VDR) ligands are therapeutic agents for the treatment of psoriasis, osteoporosis, and secondary hyperparathyroidism. VDR ligands also show immense potential as therapeutic agents for autoimmune diseases and cancers of the skin, prostate, colon, and breast as well
R Abdelmaksood et al.
Clinical laboratory, 59(3-4), 277-282 (2013-06-04)
As defensins are dysregulated in psoriasis, the present work is aimed at the assessment of the impact of topical betamethasone with and without calcipotriol on human beta-defensin 2 (hBD-2) expression and serum level in a cohort Egyptian psoriatic patients. A
N Ramnath et al.
Cancer chemotherapy and pharmacology, 71(5), 1173-1182 (2013-02-26)
Preclinical studies demonstrated antiproliferative synergy of 1,25-D3 (calcitriol) with cisplatin. The goals of this phase I/II study were to determine the recommended phase II dose (RP2D) of 1,25-D3 with cisplatin and docetaxel and its efficacy in metastatic non-small-cell lung cancer.
1/9