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Chunaram Choudhary et al.
Science (New York, N.Y.), 325(5942), 834-840 (2009-07-18)
Lysine acetylation is a reversible posttranslational modification of proteins and plays a key role in regulating gene expression. Technological limitations have so far prevented a global analysis of lysine acetylation's cellular roles. We used high-resolution mass spectrometry to identify 3600
Patrick Forterre
Journal of molecular biology, 425(23), 4714-4726 (2013-10-01)
The replicon model has initiated a major research line in molecular biology: the study of DNA replication mechanisms. Until now, the majority of studies have focused on a limited set of model organisms, mainly from Bacteria or Opisthokont eukaryotes (human
Hitesh Bhattarai et al.
Journal of bacteriology, 196(19), 3366-3376 (2014-06-25)
Nonhomologous end joining (NHEJ) is a recently described bacterial DNA double-strand break (DSB) repair pathway that has been best characterized for mycobacteria. NHEJ can religate transformed linear plasmids, repair ionizing radiation (IR)-induced DSBs in nonreplicating cells, and seal I-SceI-induced chromosomal
O Domínguez et al.
The EMBO journal, 19(7), 1731-1742 (2000-04-04)
A novel DNA polymerase has been identified in human cells. Human DNA polymerase mu (Pol mu), consisting of 494 amino acids, has 41% identity to terminal deoxynucleotidyltransferase (TdT). Human Pol mu, overproduced in Escherichia coli in a soluble form and
P A Ropp et al.
Genomics, 36(3), 449-458 (1996-09-15)
The nuclear-encoded DNA polymerase gamma (DNA POL gamma) is the sole DNA polymerase required for the replication of the mitochondrial DNA. We have cloned the cDNA for human DNA POL gamma and have mapped the gene to the chromosomal location
Fatal congenital myopathy and gastrointestinal pseudo-obstruction due to POLG1 mutations.
C Giordano et al.
Neurology, 72(12), 1103-1105 (2009-03-25)
C Morelli et al.
Cytogenetics and cell genetics, 83(1-2), 18-20 (1999-02-02)
We have localized a human homolog, REV3L, of the Saccharomyces cerevisiae REV3 gene on chromosome region 6q21. The full-length cDNA consists of 10,919 nucleotides, with a putative open reading frame of 9,159 bp for a predicted protein of 3,053 amino
Eleonora Lamantea et al.
Annals of neurology, 52(2), 211-219 (2002-09-05)
One form of familial progressive external ophthalmoplegia with multiple mitochondrial DNA deletions recently has been associated with mutations in POLG1, the gene encoding pol gammaA, the catalytic subunit of mitochondrial DNA polymerase. We screened the POLG1 gene in several PEO
Jung-Hoon Yoon et al.
The Journal of biological chemistry, 289(19), 13177-13185 (2014-03-22)
The biological functions of human DNA polymerase (pol) θ, an A family polymerase, have remained poorly defined. Here we identify a role of polθ in translesion synthesis (TLS) in human cells. We show that TLS through the thymine glycol (TG)
Massimiliano Filosto et al.
Archives of neurology, 60(9), 1279-1284 (2003-09-17)
The mendelian forms of progressive external ophthalmoplegia (PEO) associated with multiple mitochondrial DNA deletions are clinically heterogeneous disorders transmitted as dominant or recessive traits. Autosomal dominant PEO is caused by mutations in at least 3 genes: adenine nucleotide translocator-1 (ANT1)
M R Salehan et al.
British journal of biomedical science, 70(1), 31-40 (2013-04-27)
A significant barrier to effective cancer therapy is the development of resistance to the drugs utilised. Standard chemotherapeutic regimens typically contain genotoxic agents, designed to damage DNA of existing tumour cells as well as prevent the synthesis of new DNA
Kavita Bhalla et al.
American journal of human genetics, 83(6), 703-713 (2008-11-18)
Cell-adhesion molecules play critical roles in brain development, as well as maintaining synaptic structure, function, and plasticity. Here we have found the disruption of two genes encoding putative cell-adhesion molecules, CDH15 (cadherin superfamily) and KIRREL3 (immunoglobulin superfamily), by a chromosomal
Andy Weiss et al.
Infection and immunity, 82(4), 1424-1435 (2014-02-05)
In Gram-positive bacteria, and particularly the Firmicutes, the DNA-dependent RNA polymerase (RNAP) complex contains an additional subunit, termed the δ factor, or RpoE. This enigmatic protein has been studied for more than 30 years for various organisms, but its function
Masashi Miura et al.
Revista do Instituto de Medicina Tropical de Sao Paulo, 55(6), 401-406 (2013-11-12)
The use of a "direct PCR" DNA polymerase enables PCR amplification without any prior DNA purification from blood samples due to the enzyme's resistance to inhibitors present in blood components. Such DNA polymerases are now commercially available. We compared the
Joseph M Johnson et al.
Molecular and cellular biology, 33(14), 2748-2759 (2013-05-22)
Ribosomal DNA (rDNA) genes in eukaryotes are organized into multicopy tandem arrays and transcribed by RNA polymerase I. During cell proliferation, ∼50% of these genes are active and have a relatively open chromatin structure characterized by elevated accessibility to psoralen
Kristoffer T G Rigbolt et al.
Science signaling, 4(164), rs3-rs3 (2011-03-17)
To elucidate cellular events underlying the pluripotency of human embryonic stem cells (hESCs), we performed parallel quantitative proteomic and phosphoproteomic analyses of hESCs during differentiation initiated by a diacylglycerol analog or transfer to media that had not been conditioned by
Sharon Gauci et al.
Analytical chemistry, 81(11), 4493-4501 (2009-05-06)
The analysis of proteome-wide phosphorylation events is still a major analytical challenge because of the enormous complexity of protein phosphorylation networks. In this work, we evaluate the complementarity of Lys-N, Lys-C, and trypsin with regard to their ability to contribute
Raphael Ceccaldi et al.
Nature, 518(7538), 258-262 (2015-02-03)
Large-scale genomic studies have shown that half of epithelial ovarian cancers (EOCs) have alterations in genes regulating homologous recombination (HR) repair. Loss of HR accounts for the genomic instability of EOCs and for their cellular hyper-dependence on alternative poly-ADP ribose
Moneeb Ehtesham et al.
Cancer letters, 274(2), 305-312 (2008-11-15)
Increasing evidence points to a fundamental role for cancer stem cells (CSC) in the initiation and propagation of many tumors. As such, in the context of glioblastoma multiforme (GBM), the development of treatment strategies specifically targeted towards CSC-like populations may
Igor P Kovalchuk et al.
Radiation research, 182(6), 683-694 (2014-11-20)
Ionizing radiation (IR) is a well-known human carcinogen. Young and adult individuals are known to respond to radiation in a different manner. In this study, we analyzed changes in the spleen of juvenile (two-week-old), adult (two-month-old) and old (18-month-old) C57BL/6
K C Walls et al.
Journal of neuropathology and experimental neurology, 68(12), 1326-1338 (2009-11-17)
Perinatal hypoxia-ischemia may result in long-term neurological deficits. In addition to producing neuron death, HI causes death of neural precursor cells (NPCs) in the developing brain. To characterize the molecular pathways that regulate hypoxia-induced death of NPCs, we treated a
Milind K Gupta et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(18), 7252-7257 (2013-04-17)
Replication fork pausing drives genome instability, because any loss of paused replisome activity creates a requirement for reloading of the replication machinery, a potentially mutagenic process. Despite this importance, the relative contributions to fork pausing of different replicative barriers remain
S E Lim et al.
The Journal of biological chemistry, 274(53), 38197-38203 (1999-12-23)
Human DNA polymerase gamma is composed of a 140-kDa catalytic subunit and a smaller accessory protein variously reported to be 43-54 kDa. Immunoblot analysis of the purified, heterodimeric native human polymerase gamma complex identified the accessory subunit as 55 kDa.
T Kesti et al.
The Journal of biological chemistry, 268(14), 10238-10245 (1993-05-15)
The cDNA encoding the catalytic polypeptide of human DNA polymerase epsilon was cloned. The deduced amino acid sequence reveals that the catalytic polypeptide is 2257 amino acids in length and its calculated molecular mass is 258 kDa. A single RNA
Shuhei Matsuoka et al.
Science (New York, N.Y.), 316(5828), 1160-1166 (2007-05-26)
Cellular responses to DNA damage are mediated by a number of protein kinases, including ATM (ataxia telangiectasia mutated) and ATR (ATM and Rad3-related). The outlines of the signal transduction portion of this pathway are known, but little is known about
D Huang et al.
The Biochemical journal, 339 ( Pt 3), 657-665 (1999-04-24)
The catalytic subunit of human DNA polymerase epsilon, an enzyme involved in nuclear DNA replication and repair, is encoded by the POLE1 gene. This gene is composed of 51 exons spanning at least 97 kb of genomic DNA. It was
Xingming Chen et al.
Carcinogenesis, 29(11), 2120-2125 (2008-08-15)
Because p53 and p73 are associated with critical cellular processes and can be inactivated or degraded by the human papillomavirus (HPV) E6 oncoprotein, we investigated the combined effects of p53 codon 72 and p73 G4C14-to-A4T14 polymorphisms on the risk of
Yang Liu et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(5), 1789-1794 (2014-01-23)
DNA polymerase κ (Polκ) is the only known Y-family DNA polymerase that bypasses the 10S (+)-trans-anti-benzo[a]pyrene diol epoxide (BPDE)-N(2)-deoxyguanine adducts efficiently and accurately. The unique features of Polκ, a large structure gap between the catalytic core and little finger domain
[The effect of Luteococcus japonicus subsp. Casei reactivating factor on the expression of SOS response genes].
N G Loĭko et al.
Mikrobiologiia, 82(2), 139-146 (2013-07-03)
Y Wang et al.
The Journal of biological chemistry, 272(21), 13640-13646 (1997-05-23)
A full-length cDNA of the accessory (beta) subunit of mitochondrial DNA polymerase from Drosophila embryos has been obtained, and its nucleotide sequence was determined. The cDNA clone encodes a polypeptide with a deduced amino acid sequence of 361 residues and
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