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Wei Li et al.
Journal of natural products, 77(12), 2611-2618 (2014-12-02)
Six new (erinarols A-F, 1-6) and five known (7-11) ergostane-type sterol fatty acid esters were isolated from the methanol extract of the dried fruiting bodies of Hericium erinaceum. Their chemical structures were elucidated using chemical and physical methods as well
M E da Silva Ferreira et al.
Medical mycology, 43 Suppl 1, S313-S319 (2005-08-23)
The continuous use of triazoles can result in the development of drug resistance. Azole-resistant clinical isolates, spontaneous and induced mutants of Aspergillus fumigatus have been documented. The azoles block the ergosterol biosynthesis pathway by inhibiting the enzyme 14-alpha-demethylase, product of
Microbiology. How to survive being hot and inebriated.
Clint Cheng et al.
Science (New York, N.Y.), 346(6205), 35-36 (2014-10-04)
Esteban D Babot et al.
Applied and environmental microbiology, 81(12), 4130-4142 (2015-04-12)
The goal of this study is the selective oxyfunctionalization of steroids under mild and environmentally friendly conditions using fungal enzymes. With this purpose, peroxygenases from three basidiomycete species were tested for the hydroxylation of a variety of steroidal compounds, using
Carlos García-Delgado et al.
Journal of hazardous materials, 285, 259-266 (2014-12-17)
Soils impregnated with creosote contain high concentrations of polycyclic aromatic hydrocarbons (PAH). To bioremediate these soils and avoid PAH spread, different bioremediation strategies were tested, based on natural attenuation, biochar application, wheat straw biostimulation, Pleurotus ostreatus mycoremediation, and the novel
Daphne Isabel Jost et al.
Archives of animal nutrition, 67(2), 104-118 (2013-03-26)
Since more than half of the faecal nitrogen (N) originates from microbial N, the objective of the study was to develop a method for quantitatively detecting microbial biomass and portion of living microorganisms in dairy cattle faeces, including bacteria, fungi
David W P Manning et al.
Ecology, 96(8), 2214-2224 (2015-09-26)
Nitrogen (N) and phosphorus (P) concentrations are elevated in many freshwater systems, stimulating breakdown rates of terrestrially derived plant litter; however, the relative importance of N and P in driving litter breakdown via microbial and detritivore processing are not fully
Luis Caspeta et al.
Science (New York, N.Y.), 346(6205), 75-78 (2014-10-04)
Ethanol production for use as a biofuel is mainly achieved through simultaneous saccharification and fermentation by yeast. Operating at ≥40°C would be beneficial in terms of increasing efficiency of the process and reducing costs, but yeast does not grow efficiently
Stephen B Helliwell et al.
Nature communications, 6, 8613-8613 (2015-10-13)
FR171456 is a natural product with cholesterol-lowering properties in animal models, but its molecular target is unknown, which hinders further drug development. Here we show that FR171456 specifically targets the sterol-4-alpha-carboxylate-3-dehydrogenase (Saccharomyces cerevisiae--Erg26p, Homo sapiens--NSDHL (NAD(P) dependent steroid dehydrogenase-like)), an
Liliana Losada et al.
PLoS pathogens, 11(4), e1004834-e1004834 (2015-04-25)
Invasive aspergillosis (IA) due to Aspergillus fumigatus is a major cause of mortality in immunocompromised patients. The discovery of highly fertile strains of A. fumigatus opened the possibility to merge classical and contemporary genetics to address key questions about this
Mario Ruiz et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(4), 1555-1567 (2013-12-24)
Lipocalins are small extracellular proteins mostly described as lipid carriers. The Drosophila lipocalin NLaz (neural Lazarillo) modulates the IIS pathway and regulates longevity, stress resistance, and behavior. Here, we test whether a native hydrophobic pocket structure is required for NLaz
Combination treatment of ergosterol followed by amphotericin B induces necrotic cell death in human hepatocellular carcinoma cells
Lin Yu-Chun, et al.
Testing (2017)
Li-Shian Shi et al.
Bioorganic & medicinal chemistry, 19(1), 677-683 (2010-12-01)
Five new benzenoids, benzocamphorins A-E (1-5), and 10 recently isolated triterpenoids, camphoratins A-J (16-25), together with 23 known compounds including seven benzenoids (6-12), three lignans (13-15), and 13 triterpenoids (26-38) were isolated from the fruiting body of Taiwanofungus camphoratus. Their
Hong Zeng et al.
Journal of medical microbiology, 64(Pt 1), 93-103 (2014-10-30)
Fennel seed essential oil (FSEO) is a plant-derived natural therapeutic against dermatophytes. In this study, the antifungal effects of FSEO were investigated from varied aspects, such as MIC and minimum fungicidal concentration, mycelia growth, spore germination and biomass. The results
Elena Zanni et al.
Research in microbiology, 166(2), 84-92 (2015-01-13)
In Kluyveromyces lactis yeast, OCH1 encodes for the α-1,6-mannosyltrasferase that adds the initial α-1,6-mannose to the outer-chains of N-glycoproteins. Kloch1-1 mutant cells showed altered calcium homeostasis and endoplasmic reticulum (ER) stress. Since ER plays a major role in lipid biosynthesis
Giovana Anceski Bataglion et al.
Analytical chemistry, 87(15), 7771-7778 (2015-07-02)
A fast, sensitive, and selective ultrahigh-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method that is able to quantify geochemical biomarkers in sediment is described. A pool of 10 sterols, which can be used as biomarkers of autochthonous (cholesterol, cholestanol, brassicasterol
Gabriel Moretti-Almeida et al.
FEBS letters, 587(18), 3008-3013 (2013-07-31)
A thermosensitive strain (YMR134W(ts)) of the essential gene YMR134W presented up to 40% less ergosterol, threefold lower oxygen consumption and impaired growth on respiratory conditions. The iron content in the mitochondrial fraction of YMR134W(ts) cells was considerably low, despite these
K E Clemmensen et al.
Science (New York, N.Y.), 339(6127), 1615-1618 (2013-03-30)
Boreal forest soils function as a terrestrial net sink in the global carbon cycle. The prevailing dogma has focused on aboveground plant litter as a principal source of soil organic matter. Using (14)C bomb-carbon modeling, we show that 50 to
Anscha Mari Troskie et al.
Antimicrobial agents and chemotherapy, 58(7), 3697-3707 (2014-04-23)
Tyrocidines are cationic cyclodecapeptides from Bacillus aneurinolyticus that are characterized by potent antibacterial and antimalarial activities. In this study, we show that various tyrocidines have significant activity against planktonic Candida albicans in the low-micromolar range. These tyrocidines also prevented C.
Lehlohonolo Benedict Qhanya et al.
PloS one, 10(11), e0142100-e0142100 (2015-11-05)
Fungi are an exceptional source of diverse and novel cytochrome P450 monooxygenases (P450s), heme-thiolate proteins, with catalytic versatility. Agaricomycotina saprophytes have yielded most of the available information on basidiomycete P450s. This resulted in observing similar P450 family types in basidiomycetes
Yasuhisa Ano et al.
PloS one, 10(3), e0116598-e0116598 (2015-03-12)
Despite the ever-increasing number of dementia patients worldwide, fundamental therapeutic approaches to treat this disease remain to be established. Preventive approaches such as diet, exercise and learning attract attention. Several epidemiological studies suggest that ingestion of fermented dairy products prevents
B Pippi et al.
Journal of applied microbiology, 118(4), 839-850 (2015-01-08)
To evaluate the ability of Candida parapsilosis and Candida glabrata to develop phenotypic resistance to a benzophenone enriched fraction obtained from Brazilian red propolis (BZP-BRP) as compared to fluconazole (FLC). To investigate possible synergy between BZP-BRP and FLC and anidulafungin
Ricardo Dias de Castro et al.
BMC complementary and alternative medicine, 15, 417-417 (2015-11-26)
Limitations of antifungal agents used in the treatment of oral candidiasis, as the development of resistant strains, are known by the scientific community. In this context, the aim of this study was to evaluate the antifungal activity of thymol against
Sebastian Daum et al.
Biological chemistry, 395(7-8), 801-812 (2014-07-09)
As shape transformations of membranes are vital for intracellular trafficking, it is crucial to understand both the mechanics and the biochemistry of these processes. The interplay of these two factors constitutes an experimental challenge, however, because biochemical experiments are not
Arowu R Tanaka et al.
Biochemical and biophysical research communications, 430(4), 1240-1245 (2012-12-26)
Anchorage-independent growth is evidence of the malignant transformation of cells. We previously reported the characterization of anicequol, a novel inhibitor of the anchorage-independent growth of tumor cells, and here we show that the effects of 25-hydroxycholesterol (25-HC) on colon cancer
Fillipe de Oliveira Pereira et al.
Pharmaceutical biology, 53(2), 228-234 (2014-11-22)
Trichophyton rubrum is the most common fungus causing chronic dermatophytosis in humans. Antifungal activity of promising agents is of great interest. Geraniol and citronellol are monoterpenes with antimicrobial properties. This study aimed to investigate the inhibitory effects and possible mechanism
Marie L Davey et al.
Molecular ecology, 22(2), 368-383 (2012-11-30)
Although bryophytes are a dominant vegetation component of boreal and alpine ecosystems, little is known about their associated fungal communities. HPLC assays of ergosterol (fungal biomass) and amplicon pyrosequencing of the ITS2 region of rDNA were used to investigate how
Irene Ojini et al.
G3 (Bethesda, Md.), 5(9), 1925-1935 (2015-07-23)
Resistance to cancer therapy is a major obstacle in the long-term treatment of cancer. A greater understanding of drug resistance mechanisms will ultimately lead to the development of effective therapeutic strategies to prevent resistance from occurring. Here, we exploit the
Luka Kristanc et al.
Biochimica et biophysica acta, 1838(10), 2635-2645 (2014-05-28)
The influences of ergosterol and cholesterol on the activity of the nystatin were investigated experimentally in a POPC model membrane as well as theoretically. The behavior of giant unilamellar vesicles (GUVs) under osmotic stress due to the formation of transmembrane
Ameeta K Agarwal et al.
Eukaryotic cell, 7(2), 387-400 (2007-12-25)
Sampangine, a plant-derived alkaloid found in the Annonaceae family, exhibits strong inhibitory activity against the opportunistic fungal pathogens Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus. In the present study, transcriptional profiling experiments coupled with analyses of mutants were performed in
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