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G Ryzinska-Paier et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 69(6), 1349-1358 (2014-03-22)
The realisation of a novel concept for automated on-line monitoring of enzymatic activities in water was successfully demonstrated by long-term field testing at two remote Austrian ground water resources. The β-D-glucuronidase (GLUC) activity was selected as a representative enzymatic model
E Hijova et al.
Bratislavske lekarske listy, 115(2), 76-79 (2014-03-08)
Natural dietary compounds such as prebiotics modulate microbial composition and could prevent the colon cancer development as potential chemopreventive agent. Effect of prebiotic-inulin on biochemical, microbial and chemopreventive markers were examined in Sprague-Dawley rats during experimental chemically dimethylhydrazine induced colon
A I Emets et al.
TSitologiia i genetika, 47(3), 14-20 (2013-07-05)
The results on in vitro culture establishment, plantlet regeneration and rooting of Camelina sativa cultivar sample Peremozhets and cultivar Mirazh are presented. Effective concentrations of sterilizing agents and duration of plant material treatment were estimated. Phytohormone ratio, sucrose concentration in
Kar Wai Tan et al.
Blood, 122(22), 3666-3677 (2013-10-12)
Lymphangiogenesis is an important physiological response to inflammatory insult, acting to limit inflammation. Macrophages, dendritic cells, and lymphocytes are known to drive lymphangiogenesis. In this study, we show that neutrophils recruited to sites of inflammation can also coordinate lymphangiogenesis. In
Jennifer C Wilson et al.
Biochemical and biophysical research communications, 443(1), 185-188 (2013-12-03)
Heparanase is an endo-β-glucuronidase that cleaves heparan sulfate side chains of proteoglycans in basement membranes and the extracellular matrix (ECM). Heparanase is implicated in several diverse pathological processes associated with ECM degradation such as metastasis, inflammation and angiogenesis and is
Guo-Qiang Hu et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(24), 3793-3798 (2013-05-01)
To study the developmental phase on the growth and active compounds in Scutellaria baicalensis. Seeds of wild plants were collected from Laiwu and sowed in Fangshan (Beijing) and Laiwu (Shandong). Samples of aerial and underground parts were collected in five
Carlos Munoz et al.
FEBS letters, 587(11), 1663-1668 (2013-04-23)
Klotho, a hormone and enzyme, is a powerful regulator of ageing and life span. Klotho deficiency leads to cardiac arrythmia and sudden cardiac death. We thus explored whether klotho modifies cardiac K(+)-channel hERG. Current was determined utilizing dual electrode voltage
Xiaoming Ye et al.
PloS one, 8(1), e55615-e55615 (2013-02-06)
βKlotho is a regulator in multiple metabolic processes, while its role in cancer remains unclear. We found the expression of βKlotho was down-regulated in human hepatocellular carcinoma tissues compared with that in paired adjacent non-tumourous liver tissues. Hepatoma cells also
Christoph Schmid et al.
The Journal of endocrinology, 219(2), R37-R57 (2013-10-08)
Acromegaly is characterized by excessively high GH and IGF1 levels. Recent data suggest that soluble Klotho (sKlotho) is also elevated in patients with active acromegaly. sKlotho decreases towards normal following removal of the GH-producing pituitary adenoma. The Klotho gene was
Anjum Riaz et al.
The Journal of biological chemistry, 288(17), 12366-12375 (2013-03-19)
Heparanase functions as a heparan sulfate-degrading enzyme and as a ligand for an unidentified signaling receptor(s). Here, several reactions involved in the activation of the PI3K-AKT pathway by latent heparanase were characterized. Protein suppression using specific siRNAs revealed that heparanase-induced
Tissue distribution of quercetin in rats and pigs
de Boer VCJ, et al.
The Journal of Nutrition, 135(7), 1718-1725 (2005)
Jyothsna Gattineni et al.
American journal of physiology. Renal physiology, 306(3), F351-F358 (2013-11-22)
Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that acts on the proximal tubule to decrease phosphate reabsorption and serum levels of 1,25-dihydroxyvitamin D₃ [1,25(OH)₂ Vitamin D₃]. Abnormal FGF23 metabolism has been implicated in several debilitating hypophosphatemic and hyperphosphatemic
Production and properties of bacterial beta-glucuronidase.
M L DOYLE et al.
The Journal of biological chemistry, 217(2), 921-930 (1955-12-01)
Pritu Pratibha et al.
Gene, 524(1), 22-27 (2013-04-25)
Investigation of the transgenic Arabidopsis promoter trap line GFP-868 that showed GFP expression only in anthers revealed the T-DNA insertion at 461bp upstream to the hypothetical gene At4g10596 with the GFP reporter gene in head-to-head orientation to the At4g10596 gene.
Yu Zhu et al.
Cancer science, 104(6), 663-671 (2013-02-26)
Klotho is an anti-aging protein predominantly expressed in renal tubular epithelial cells. Although Klotho was recently identified as a tumor suppressor gene in a variety of cancers, the potential role and molecular events for Klotho in renal cell carcinoma (RCC)
Hendrik Modick et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 925, 33-39 (2013-03-23)
N-Acetyl-4-aminophenol (NAAP) is the major urinary metabolite of aniline. The general population is known to be ubiquitously exposed to aniline through various sources. Furthermore, NAAP, known under the trade name paracetamol (resp. acetaminophen), is one of the most commonly used
Ivana Hálová et al.
The Journal of biological chemistry, 288(14), 9801-9814 (2013-02-28)
Chemotaxis, a process leading to movement of cells toward increasing concentrations of chemoattractants, is essential, among others, for recruitment of mast cells within target tissues where they play an important role in innate and adaptive immunity. Chemotaxis is driven by
Olga Ostrovsky et al.
Journal of leukocyte biology, 95(4), 677-688 (2013-12-10)
Heparanase is an endo-β-glucuronidase that specifically cleaves the saccharide chains of HSPGs, important structural and functional components of the ECM. Cleavage of HS leads to loss of the structural integrity of the ECM and release of HS-bound cytokines, chemokines, and
Mark Kinkema et al.
Plant molecular biology, 84(4-5), 443-454 (2013-10-22)
Chemically inducible gene switches can provide precise control over gene expression, enabling more specific analyses of gene function and expanding the plant biotechnology toolkit beyond traditional constitutive expression systems. The alc gene expression system is one of the most promising
The comparative ability of beta-glucuronidase preparations (liver, Escherichia coli, Helix pomatia, and Patella vulgata) to hydrolyze certain steroid glucosiduronic acids.
M WAKABAYASHI et al.
The Journal of biological chemistry, 236, 996-1001 (1961-04-01)
Brian Latimer et al.
Anticancer research, 35(12), 6411-6418 (2015-12-08)
Curcumin is a promising nutraceutical for chemoprevention of head and neck squamous cell carcinoma (HNSCC). Capsular formulations of curcumin demonstrate low systemic bioavailability. We aimed to determine if curcumin levels were higher in healthy volunteers and cancer patients with microgranular
Shu Feng et al.
Cancer research, 73(8), 2551-2562 (2013-02-27)
Prostate cancer is the most common visceral malignancy and the second leading cause of cancer deaths in US men. There is broad evidence that fibroblast growth factor (FGF) receptors are important in prostate cancer initiation and progression, but the contribution
Yunbao Liu et al.
Organic letters, 15(20), 5206-5209 (2013-10-08)
Penicillactones A-C (1-3) are structurally related natural products with a spirocyclic anhydride structure and were isolated from the endophytic fungus Penicillium dangeardii Pitt. Penicillactones B and C showed inhibition of the release of β-glucuronidase from polymorphonuclear leukocytes with ED50 values
Ying Wang et al.
Arteriosclerosis, thrombosis, and vascular biology, 33(5), 894-902 (2013-03-09)
After diabetes mellitus, transfer of lipoprotein lipase (LPL) from cardiomyocytes to the coronary lumen increases, and this requires liberation of LPL from the myocyte surface heparan sulfate proteoglycans with subsequent replenishment of this reservoir. At the lumen, LPL breaks down
Nobuaki Higashi et al.
The Biochemical journal, 458(2), 291-299 (2013-12-19)
Heparanase cleaves macromolecular heparin in the secretory granules of connective tissue-type mast cells. We investigated roles of the cleavage under a microenvironment mimicking where the mast cells physiologically reside. A connective tissue-type mast cell line MST and mouse peritoneal cell-derived
Amichay Meirovitz et al.
The FEBS journal, 280(10), 2307-2319 (2013-02-13)
Recent years have seen a growing body of evidence that enzymatic remodeling of heparan sulfate proteoglycans profoundly affects a variety of physiological and pathological processes, including inflammation, neovascularization, and tumor development. Heparanase is the sole mammalian endoglycosidase that cleaves heparan
Dahai Zhang et al.
Arteriosclerosis, thrombosis, and vascular biology, 33(12), 2830-2838 (2013-10-12)
During diabetes mellitus, coronary lipoprotein lipase increases to promote the predominant use of fatty acids. We have reported that high glucose stimulates active heparanase secretion from endothelial cells to cleave cardiomyocyte heparan sulfate and release bound lipoprotein lipase for transfer
E I Parker et al.
The British journal of radiology, 87(1033), 20130467-20130467 (2013-11-16)
Lysosomal storage diseases (LSDs) are a large group of genetic metabolic disorders that result in the accumulation of abnormal material, such as mucopolysaccharides, glycoproteins, amino acids and lipids, within cells. Since many LSDs manifest during infancy or early childhood, with
GC-MS methods for metabolic profiling of microbial fermentation products of dietary polyphenols in human and in vitro intervention studies
Grun CH, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 871(2), 212-219 (2008)
[Not Available].
W H FISHMAN
Advances in enzymology and related subjects of biochemistry, 16, 361-409 (1955-01-01)
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