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Samaneh Ekhteraei-Tousi et al.
Journal of cellular biochemistry, 116(1), 179-191 (2014-08-29)
The cardiac cells generation via stem cells differentiation is a promising approach to restore the myocardial infarction. Promoted by our primary bioinformatics analysis as well as some previously published data on potential role of hsa-miR-590-3p in cardiogenesis, we have tried
Alessandra Fiorio Pla et al.
BMC cancer, 14, 939-939 (2014-12-17)
Prostate cancer is the second leading cause of male cancer death in developed countries. Although the role of angiogenesis in its progression is well established, the efficacy of anti-angiogenic therapy is not clearly proved. Whether this could depend on differential
Joni H Ylostalo et al.
Cytotherapy, 16(11), 1486-1500 (2014-09-19)
Human mesenchymal stromal cells (MSCs) are being used in clinical trials, but the best protocol to prepare the cells for administration to patients remains unclear. We previously demonstrated that MSCs could be pre-activated to express therapeutic factors by culturing the
Anne Hamacher-Brady et al.
The Journal of biological chemistry, 290(36), 22005-22018 (2015-07-03)
Efficient apoptosis requires Bax/Bak-mediated mitochondrial outer membrane permeabilization (MOMP), which releases death-promoting proteins cytochrome c and Smac to the cytosol, which activate apoptosis and inhibit X-linked inhibitor of apoptosis protein (XIAP) suppression of executioner caspases, respectively. We recently identified that
Zhi-xin Yu et al.
Critical care (London, England), 19, 82-82 (2015-04-19)
Recent studies have revealed that lung inflammation mediated by CD4+ T cells may contribute to the pathogenesis of acute respiratory distress syndrome (ARDS). The imbalance between CD4 + CD25 + Foxp3 + regulatory T (Treg) cells and T helper (Th)17 cells has been found in a
Yawen Wang et al.
International immunopharmacology, 25(2), 363-369 (2015-02-14)
Hepatitis B virus (HBV) infection is one of the major causes of chronic liver diseases. The current therapeutics show limited efficacy. In the HBV life cycle, virus core antigen (HBcAg) plays important multiple roles. Blocking the pleiotropic functions of HBcAg
Hina Mir et al.
Oncotarget, 6(12), 9985-9998 (2015-04-19)
Lung cancer (LuCa) is the leading cause of cancer-related deaths worldwide regardless of the gender. High mortality associated with LuCa is due to metastasis, molecular mechanisms of which are yet to be defined. Here, we present evidence that chemokine receptor
Louise M Collins et al.
Molecular neurobiology, 51(3), 1432-1442 (2014-07-30)
Small molecule histone deacetylase inhibitors (HDIs) hold much promise as pharmacological modifiers of the epigenetic status of the central nervous system (CNS), given their ability to cross the blood-brain barrier. This is particularly relevant given the lack of disease-modifying therapies
Ronak Savla et al.
Pharmaceutical research, 31(12), 3487-3502 (2014-06-13)
Design and synthesis of a tumor responsive nanoparticle-based system for imaging and treatment of various cancers. Manganese oxide nanoparticles (Mn3O4 NPs) were synthesized and modified with LHRH targeting peptide or anti-melanoma antibodies (cancer targeting moieties) and a MMP2 cleavable peptide
Andrew W DeVilbiss et al.
Molecular and cellular biology, 35(12), 2073-2087 (2015-04-10)
Erythropoiesis, in which committed progenitor cells generate millions of erythrocytes daily, involves dramatic changes in the chromatin structure and transcriptome of erythroblasts, prior to their enucleation. While the involvement of the master-regulatory transcription factors GATA binding protein 1 (GATA-1) and
Vera Gesheva et al.
International immunopharmacology, 26(1), 162-168 (2015-03-25)
New generated subunit vaccines are characterized by increased safety and lack of side effects, however they suffer from weak immunogenicity. The adjuvants are substances that have the ability to enhance the magnitude and duration of the immune response and to
Kathrin Keeren et al.
Biology, 4(2), 314-326 (2015-04-11)
Omega-6 and omega-3 polyunsaturated fatty acids (n-6 and n-3 PUFA) can modulate inflammatory processes. In western diets, the content of n-6 PUFA is much higher than that of n-3 PUFA, which has been suggested to promote a pro-inflammatory phenotype. The
Merryl R Lobo et al.
PloS one, 9(12), e114110-e114110 (2014-12-10)
We have previously reported that the in vivo anti-glioma efficacy of the anti-angiogenic receptor tyrosine kinase inhibitor cediranib is substantially enhanced via combination with the late-stage autophagy inhibitor quinacrine. The current study investigates the role of hypoxia and autophagy in
Carlyn A Figueiredo et al.
PloS one, 9(7), e101947-e101947 (2014-08-01)
Intravenous immunoglobulin (IVIg) has been used to treat a variety of autoimmune disorders including multiple sclerosis (MS); however its mechanism of action remains elusive. Recent work has shown that interleukin-11 (IL-11) mRNAs are upregulated by IVIg in MS patient T
In-Kyung Lee et al.
World journal of gastroenterology, 21(22), 6872-6883 (2015-06-17)
To investigate the mechanism of endoplasmic reticulum (ER) stress induction by an occult infection related hepatitis B virus S surface antigen (HBsAg) variant. We used an HBsAg variant with lower secretion capacity, which was a KD variant from a Korean
Hao Guo et al.
Archives of oral biology, 60(1), 199-207 (2014-12-03)
Ubiquitous environmental pollutants such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) cause abnormalities in reproduction and development. TCDD inhibits the development of teeth, and its effects depend on its dose and the developmental stage of the tooth. Our aim here was to investigate the
I Kusumoto
The Journal of nutrition, 131(9 Suppl), 2552S-2555S (2001-09-05)
The industrial production of L-glutamine (L-Gln) started with its fermentation in the late 1960s. Currently, it is manufactured for use as pharmaceuticals and health foods at the worldwide annual production of approximately 2000 metric tons. To manufacture high quality L-Gln
Jennifer V E Brown et al.
The Cochrane database of systematic reviews, 12(12), CD005947-CD005947 (2014-12-17)
Endogenous glutamine biosynthesis may be insufficient to meet the needs of people with severe gastrointestinal disease. Results from studies using experimental animal models of gastrointestinal disease have suggested that glutamine supplementation improves clinical outcomes. This review examines evidence on the
Ethan B Butler et al.
Cancer research, 73(9), 2709-2717 (2013-04-24)
Cancer cells are markedly different from normal cells with regards to how their metabolic pathways are used to fuel cellular growth and survival. Two basic metabolites that exemplify these differences through increased uptake and altered metabolic usage are glucose and
Diane C Forbes et al.
Macromolecular bioscience, 14(8), 1096-1105 (2014-04-23)
This work investigates the interactions of a polycationic nanocarrier with siRNA and with cells in order to better understand the capabilities and limitations of the carrier. The polycationic nanocarriers are cross-linked copolymer nanoparticles synthesized in a single-step reaction using ARGET
Jose A Morales-Garcia et al.
Neurobiology of aging, 36(2), 1160-1173 (2014-12-03)
Different studies have suggested that the nucleotide cyclic adenosine 3', 5'-monophosphate can actively play an important role as a neuroprotective and anti-inflammatory agent after a brain injury. The phosphodiesterase 7 (PDE7) enzyme is one of the enzymes responsible for controlling
Ji-Ae Kim et al.
Oncotarget, 6(34), 35324-35343 (2015-10-17)
Varicella zoster virus (VZV) is the etiological agent of shingles, a painful skin rash that affects a significant proportion of the elderly population. In the present study, we used two aging cell models, Hutchinson-Gilford progeria syndrome (HGPS) fibroblasts and stress
B Michaud et al.
Allergy, 69(11), 1473-1480 (2014-07-22)
Cow's milk allergy (CMA) is a frequent food allergy in young children. The oral food challenge is the gold standard for diagnosis, and there is currently no reliable biological test. Our aim was to evaluate the diagnostic potential of a
Lucian Farcal et al.
PloS one, 10(5), e0127174-e0127174 (2015-05-23)
Nanomaterials (NMs) display many unique and useful physico-chemical properties. However, reliable approaches are needed for risk assessment of NMs. The present study was performed in the FP7-MARINA project, with the objective to identify and evaluate in vitro test methods for
Min-Min Lee et al.
Chemico-biological interactions, 236, 19-30 (2015-04-23)
Pipoxolan has been reported to have antitumor activity. However, the effects of pipoxolan on lung cancer cell metastasis remains unclear. This study examined the anti-metastatic effects of pipoxolan on lung adenocarcinoma cancer cells (i.e. CL1-5, CL1-0, and A549) and its
Xinghua Zhu et al.
Experimental cell research, 335(2), 216-223 (2015-05-31)
Enolases are glycolytic enzymes responsible for the ATP-generated conversion of 2-phosphoglycerate to phosphoenolpyruvate. In addition to the glycolytic function, Enolase 1 (ENO1) has been reported up-regulation in several tumor tissues. In this study, we investigated the expression and biologic function
Samia Yazid et al.
Journal of autoimmunity, 58, 1-11 (2015-01-27)
Annexin-A1 (Anx-A1) is an endogenous anti-inflammatory molecule and while described as a repressor of innate immune responses, the role of Anx-A1 in adaptive immunity, and in particular in T helper (Th) cell responses, remains controversial. We have used a T-cell
Guangyu Li et al.
Scientific reports, 5, 11271-11271 (2015-06-11)
Microcystin-LR (MCLR) is a commonly acting potent hepatotoxin and has been pointed out of potentially causing neurotoxicity, but the exact mechanisms of action still remain unclear. Using proteomic analysis, forty-five proteins were identified to be significantly altered in hippocampal neurons
Edyta Bajak et al.
Toxicology letters, 233(2), 187-199 (2014-12-20)
Higher efficacy and safety of nano gold therapeutics require examination of cellular responses to gold nanoparticles (AuNPs). In this work we compared cellular uptake, cytotoxicity and RNA expression patterns induced in Caco-2 cells exposed to AuNP (5 and 30nm). Cellular
Michael Weichhaus et al.
Cancer medicine, 3(5), 1112-1125 (2014-07-01)
Osteoprotegerin (OPG) is a secreted member of the tumor necrosis factor (TNF) receptor superfamily that has been well characterized as a negative regulator of bone remodeling. OPG is also expressed in human breast cancer tissues and cell lines. In vitro
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