P9029

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Pulmonary tuberculosis patients with a vitamin D deficiency demonstrate low local expression of the antimicrobial peptide LL-37 but enhanced FoxP3+ regulatory T cells and IgG-secreting cells.

Sayma Rahman et al.

Clinical immunology (Orlando, Fla.), 156(2), 85-97 (2014-12-17)

Control of human tuberculosis (TB) requires induction and maintenance of both macrophage and T cell effector functions. We demonstrate that pulmonary TB patients with a vitamin D deficiency had significantly reduced local levels of the vitamin D-inducible antimicrobial peptide LL-37

Studies on the Formation of Maillard and Caramelization Products from Glucosamine Incubated at 37 °C.

Yuliya Hrynets et al.

Journal of agricultural and food chemistry, 63(27), 6249-6261 (2015-06-27)

This experiment compared the in vitro degradation of glucosamine (GlcN), N-acetylglucosamine, and glucose in the presence of NH3 incubated at 37 °C in phosphate buffer from 0.5 to 12 days. The reactions were monitored with UV-vis absorption and fluorescence emission

Diagnostic Accuracy of Recombinant Immunoglobulin-like Protein A-Based IgM ELISA for the Early Diagnosis of Leptospirosis in the Philippines.

Emi Kitashoji et al.

PLoS neglected tropical diseases, 9(6), e0003879-e0003879 (2015-06-26)

Leptospirosis is an important but largely under-recognized public health problem in the tropics. Establishment of highly sensitive and specific laboratory diagnosis is essential to reveal the magnitude of problem and to improve treatment. This study aimed to evaluate the diagnostic

Electrochemical detection of protein by using magnetic graphene-based target enrichment and copper nanoparticles-assisted signal amplification.

Jing Zhao et al.

The Analyst, 140(22), 7818-7822 (2015-10-16)

In this paper, we propose a new method for protein detection by making use of magnetic graphene for enrichment and separation of the targets and duplex DNA-templated copper nanoparticles for amplification of electrochemical signals. Because the binding of the target

Comparative evaluation of Strongyloides ratti and S. stercoralis larval antigen for diagnosis of strongyloidiasis in an endemic area of opisthorchiasis.

Chatanun Eamudomkarn et al.

Parasitology research, 114(7), 2543-2551 (2015-04-17)

The use of Strongyloides ratti as heterologous antigen for serodiagnosis of strongyloidiasis is preferable to Strongyloides from humans due to the ease and safety of antigen preparation. In Southeast Asia where Opisthorchis viverrini coexists with Strongyloides stercoralis, there has been

Maternal allopurinol administration during suspected fetal hypoxia: a novel neuroprotective intervention? A multicentre randomised placebo controlled trial.

Joepe J Kaandorp et al.

Archives of disease in childhood. Fetal and neonatal edition, 100(3), F216-F223 (2014-12-17)

To determine whether maternal allopurinol treatment during suspected fetal hypoxia would reduce the release of biomarkers associated with neonatal brain damage. A randomised double-blind placebo controlled multicentre trial. We studied women in labour at term with clinical indices of fetal

Generation of an attenuated Salmonella-delivery strains expressing adhesin and toxin antigens for progressive atrophic rhinitis, and evaluation of its immune responses in a murine model.

Hoyeon Byeon et al.

Vaccine, 32(39), 5057-5064 (2014-07-22)

An expression/secretion plasmid containing genes encoding the FimA, CP39, PtfA, ToxA and F1P2 antigens associated with porcine pneumonic pasteurellosis and progressive atrophic rhinitis (PAR) was constructed and harbored in an attenuated Salmonella Typhimurium, which was used as the vaccine candidate.

Serological markers for monitoring historical changes in malaria transmission intensity in a highly endemic region of Western Kenya, 1994-2009.

Jacklyn Wong et al.

Malaria journal, 13, 451-451 (2014-11-25)

Monitoring local malaria transmission intensity is essential for planning evidence-based control strategies and evaluating their impact over time. Anti-malarial antibodies provide information on cumulative exposure and have proven useful, in areas where transmission has dropped to low sustained levels, for

Novel roles of ginsenoside Rg3 in apoptosis through downregulation of epidermal growth factor receptor.

Eun Ji Joo et al.

Chemico-biological interactions, 233, 25-34 (2015-04-01)

Ginsenoside Rg3 (Rg3), a pharmacologically active compound from red ginseng, has been reported to induce cell death in various cancer cell lines, although the specific mechanisms have not been well established. In the present study, Rg3 treatment to A549 human

New Anti-Nodal Monoclonal Antibodies Targeting the Nodal Pre-Helix Loop Involved in Cripto-1 Binding.

Annalia Focà et al.

International journal of molecular sciences, 16(9), 21342-21362 (2015-09-16)

Nodal is a potent embryonic morphogen belonging to the TGF-β superfamily. Typically, it also binds to the ALK4/ActRIIB receptor complex in the presence of the co-receptor Cripto-1. Nodal expression is physiologically restricted to embryonic tissues and human embryonic stem cells

Multiple functions of CXCL12 in a syngeneic model of breast cancer.

Sharon A Williams et al.

Molecular cancer, 9, 250-250 (2010-09-21)

A growing body of work implicates chemokines, in particular CXCL12 and its receptors, in the progression and site-specific metastasis of various cancers, including breast cancer. Various agents have been used to block the CXCL12-CXCR4 interaction as a means of inhibiting

BILL-cadherin/cadherin-17 contributes to the survival of memory B cells.

Shuichi Funakoshi et al.

PloS one, 10(1), e0117566-e0117566 (2015-01-23)

Memory B cells (MBCs) and long-lived plasma cells (LLPCs) are responsible for immunological "memory", which can last for many years. The long-term survival niche for LLPCs in the bone marrow is well characterized; however, the corresponding niche for MBCs is

Studies on molecular structure and tautomerism of a vitamin B6 analog with density functional theory.

Suban K Sahoo et al.

Journal of molecular modeling, 18(5), 1993-2001 (2011-08-31)

This work presents a computational study on the molecular structure and tautomeric equilibria of a novel Schiff base L derived from pyridoxal (PL) and o-phenylenediamine by using the density functional method B3LYP with basis sets 6-31 G(d,p), 6-31++G(d,p), 6-311 G(d,p) and 6-311++G(d,p).

Anti-GITR agonist therapy intrinsically enhances CD8 T cell responses to chronic lymphocytic choriomeningitis virus (LCMV), thereby circumventing LCMV-induced downregulation of costimulatory GITR ligand on APC.

Derek L Clouthier et al.

Journal of immunology (Baltimore, Md. : 1950), 193(10), 5033-5043 (2014-10-05)

The costimulatory TNFR family member GITR can provide important survival signals for CD8 T cells. However, little is known about the regulation of this pathway during a chronic infection. In this study, we show that GITR ligand (GITRL) is maximally

Isolation of chick retina cones and study of their diversity based on oil droplet colour and nucleus position.

R López-López et al.

Cell and tissue research, 332(1), 13-24 (2008-02-13)

The chick retina has four morphological cone types that differ not only in shape, but also in the visual pigment in the outer segment, in the colour of the oil droplet in the inner segment and in synaptic connectivity. Neither

Carcinogenicity of ortho-phenylenediamine dihydrochloride in rats and mice by two-year drinking water treatment.

Michiharu Matsumoto et al.

Archives of toxicology, 86(5), 791-804 (2012-01-25)

The carcinogenicity of ortho-phenylenediamine (o-PD) was examined by administrating o-phenylenediamine dihydrochloride (o-PD2HCl) in dinking water to groups of 50 F344/DuCrj rats and 50 Crj:BDF₁ mice of both sexes for 2 years. The drinking water concentration of o-PD2HCl was 0, 500

M2e-immobilized gold nanoparticles as influenza A vaccine: Role of soluble M2e and longevity of protection.

Wenqian Tao et al.

Vaccine, 33(20), 2307-2315 (2015-04-07)

Influenza virus causes seasonal epidemics and also poses a high risk for pandemics. To develop a broadly cross-protective influenza vaccine we have previously shown that a formulation consisting of the extracellular domain of M2 membrane protein (M2e) immobilized on gold

Role of mannose-binding lectin deficiency in HIV-1 and schistosoma infections in a rural adult population in Zimbabwe.

Rutendo B L Zinyama-Gutsire et al.

PloS one, 10(4), e0122659-e0122659 (2015-04-02)

Polymorphism in the MBL2 gene lead to MBL deficiency, which has been shown to increase susceptibility to various bacterial, viral and parasitic infections. We assessed role of MBL deficiency in HIV-1 and schistosoma infections in Zimbabwean adults enrolled in the

Spectrophotometric quantification of lactose in solution with a peroxidase-based enzymatic cascade reaction system.

Sara Fornera et al.

Analytical and bioanalytical chemistry, 401(7), 2307-2310 (2011-08-17)

A spectrophotometric assay was developed for the quantification of lactose in aqueous solution via a one-pot enzymatic cascade reaction at 25 °C and pH 7.2. Lactose (0.2-1.8 mM), E. coli β-galactosidase (β-Gal), Aspergillus niger glucose oxidase (GOD), horseradish peroxidase (HRP)

Bifidobacterium breve C50 secretes lipoprotein with CHAP domain recognized in aggregated form by TLR2.

Angelo Scuotto et al.

Biochimie, 107 Pt B, 367-375 (2014-12-03)

Extracellular components secreted by Bifidobacterium breve C50 can induce maturation, high IL-10 production and prolonged survival of dendritic cells via a TLR2 pathway. In this study, the components were isolated from the supernatant by gel filtration chromatography. Antibodies raised against

Protection against H5N1 by multiple immunizations with seasonal influenza vaccine in mice is correlated with H5 cross-reactive antibodies.

Anna Roos et al.

Vaccine, 33(14), 1739-1747 (2015-02-11)

Current seasonal influenza vaccines are believed to confer protection against a narrow range of virus strains. However, their protective ability is commonly estimated based on an in vitro correlate of protection that only considers a subset of anti-influenza antibodies that

Comparative analysis of the profiles of IgG subclass-specific responses to Plasmodium falciparum apical membrane antigen-1 and merozoite surface protein-1 in naturally exposed individuals living in malaria hypoendemic settings, Iran.

Maryam Rouhani et al.

Malaria journal, 14, 58-58 (2015-02-06)

Plasmodium falciparum apical membrane antigen-1 (PfAMA-1) and the 19-kDa C-terminal region of merozoite surface protein-1 (PfMSP-1₁₉) are candidate malaria vaccine antigens expressed on merozoites and sporozoites. This investigation was performed to evaluate simultaneously the naturally-acquired antibodies to PfAMA-1 and PfMSP-1₁₉

[Antioxidant activity of oxygen-containing aromatic compounds].

M V Potapovich et al.

Prikladnaia biokhimiia i mikrobiologiia, 47(4), 386-396 (2011-09-29)

Inhibition efficiency (antioxidant activity) of 26 oxygen-containing aromatic compounds was studied in methemalbumin-H202-o-phenylenediamine (PDA) or tetramethylbenzidine (TMB) pseudoperoxidase system at 20 degrees C in buffered physiological solution (pH 7.4) containing 6% DM F and 0.25% DMSO. The inhibitor's efficiency was

Zearalenone-induced changes in the lymphoid tissue and mucosal nerve fibers in the porcine ileum.

K Obremski et al.

Polish journal of veterinary sciences, 18(2), 357-365 (2015-07-15)

This is the first study to examine zearalenone-(ZEN) induced changes in the immune system of the ileum and substance P-(SP-) and vasoactive intestinal peptide-(VIP-) immunoreactive nerve fibers in the mucosa, which participate in the regulation of intestinal functions under physiological

Screening of inhibitors for oxidase mimics of Au@Pt nanorods by catalytic oxidation of OPD.

Jianbo Liu et al.

Chemical communications (Cambridge, England), 47(39), 10981-10983 (2011-09-13)

Nanostructured materials are a new class of enzyme mimics, the inhibitors of which have not been studied. Herein, we demonstrate the screening of inhibitors for Au@Pt nanorod (NR) oxidase mimics. In addition, based on the enzyme inhibition reaction, determination of

Influence of phospholipid types and animal models on the accelerated blood clearance phenomenon of PEGylated liposomes upon repeated injection.

Huan Xu et al.

Drug delivery, 22(5), 598-607 (2014-02-15)

When polyethylene glycol (PEG)ylated liposomes were repeatedly injected into the same animal, the second dose of liposomes would rapidly clear from the bloodstream and enhance accumulation in the liver and spleen, and this phenomenon is called "accelerated blood clearance (ABC)".

Docosahexaenoic acid and eicosapentaenoic acid suppress adhesion molecule expression in human aortic endothelial cells via differential mechanisms.

Chun-Ying Huang et al.

Molecular nutrition & food research, 59(4), 751-762 (2015-01-30)

Dietary PUFAs modulate the progression of cardiovascular disease, but the underlying mechanisms within vascular cells remain unclear. The aim of this study was to investigate the biological function and regulatory mechanisms of PUFAs in LPS-activated human aortic endothelial cells (HAECs).

Site-directed mutagenesis of tobacco anionic peroxidase: Effect of additional aromatic amino acids on stability and activity.

A A Poloznikov et al.

Biochimie, 115, 71-77 (2015-05-11)

Tobacco anionic peroxidase (TOP) is known to effectively catalyze luminol oxidation without enhancers, in contrast to horseradish peroxidase (HRP). To pursue structure-activity relationship studies for TOP, two amino acids have been chosen for mutation, namely Thr151, close to the heme

Oral streptococci utilize a Siglec-like domain of serine-rich repeat adhesins to preferentially target platelet sialoglycans in human blood.

Lingquan Deng et al.

PLoS pathogens, 10(12), e1004540-e1004540 (2014-12-05)

Damaged cardiac valves attract blood-borne bacteria, and infective endocarditis is often caused by viridans group streptococci. While such bacteria use multiple adhesins to maintain their normal oral commensal state, recognition of platelet sialoglycans provides an intermediary for binding to damaged

Lipids Promote Glycated Phospholipid Formation by Inducing Hydroxyl Radicals in a Maillard Reaction Model System.

Lipeng Han et al.

Journal of agricultural and food chemistry, 67(28), 7961-7967 (2019-07-02)

Food-derived glycated phospholipids is potentially hazardous to human health. However, there are few studies on the effects of lipids on the formation of glycated phospholipids. In this work, two model systems were established: (1) a model system including 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (PE)

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