SAB2501666

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Chronic toluene exposure induces cell proliferation in the mice SVZ but not migration through the RMS.

Ireri Franco et al.

Neuroscience letters, 575, 101-106 (2014-06-03)

Abuse of toluene-containing inhalants is associated to various cognitive impairments that have been partly associated to deviation of the hippocampal neurogenesis processes during adulthood. In the present study we analyzed the effect of chronic toluene exposure (6000ppm) on cell proliferation

p63 and p73 coordinate p53 function to determine the balance between survival, cell death, and senescence in adult neural precursor cells.

M P Fatt et al.

Cell death and differentiation, 21(10), 1546-1559 (2014-05-09)

The p53 family members p73 and p63 have been implicated in various aspects of stem cell regulation. Here, we have asked whether they work together to regulate stem cell biology, focusing upon neural precursor cells (NPCs) in the adult murine

VGF (TLQP-62)-induced neurogenesis targets early phase neural progenitor cells in the adult hippocampus and requires glutamate and BDNF signaling.

Smita Thakker-Varia et al.

Stem cell research, 12(3), 762-777 (2014-04-22)

The neuropeptide VGF (non-acronymic), which has antidepressant-like effects, enhances adult hippocampal neurogenesis as well as synaptic activity and plasticity in the hippocampus, however the interaction between these processes and the mechanism underlying this regulation remain unclear. In this study, we

Increased gyrification and aberrant adult neurogenesis of the dentate gyrus in adult rats.

Alejandra Magagna-Poveda et al.

Brain structure & function, 222(9), 4219-4237 (2017-06-29)

A remarkable example of maladaptive plasticity is the development of epilepsy after a brain insult or injury to a normal animal or human. A structure that is considered central to the development of this type of epilepsy is the dentate

Speed control for neuronal migration in the postnatal brain by Gmip-mediated local inactivation of RhoA.

Haruko Ota et al.

Nature communications, 5, 4532-4532 (2014-07-31)

Throughout life, new neurons generated in the ventricular-subventricular zone take the long journey to the olfactory bulb. The intracellular mechanisms that precisely control the neurons' migration speed, enabling their well-organized movement, remain unclear. Rho signalling is known to affect the

The selective glucocorticoid receptor modulator CORT108297 restores faulty hippocampal parameters in Wobbler and corticosterone-treated mice.

Maria Meyer et al.

The Journal of steroid biochemistry and molecular biology, 143, 40-48 (2014-02-26)

Mutant Wobbler mice are models for human amyotrophic lateral sclerosis (ALS). In addition to spinal cord degeneration, Wobbler mice show high levels of blood corticosterone, hyperactivity of the hypothalamic-pituitary-adrenal axis and abnormalities of the hippocampus. Hypersecretion of glucocorticoids increase hippocampus

μ-Opioid receptors mediate the effects of chronic ethanol binge drinking on the hippocampal neurogenic niche.

Candice Contet et al.

Addiction biology, 19(5), 770-780 (2013-03-07)

Ethanol exposure and withdrawal alter the generation of new neurons in the adult hippocampus. The endogenous opioid system, particularly the μ-opioid receptor (MOR), can modulate neural progenitors and also plays a critical role in ethanol drinking and dependence. In the

Lixisenatide, a drug developed to treat type 2 diabetes, shows neuroprotective effects in a mouse model of Alzheimer's disease.

Paula L McClean et al.

Neuropharmacology, 86, 241-258 (2014-08-12)

Type 2 diabetes is a risk factor for developing Alzheimer's disease (AD). In the brains of AD patients, insulin signalling is desensitised. The incretin hormone Glucagon-like peptide-1 (GLP-1) facilitates insulin signalling, and analogues such as liraglutide are on the market

Neural progenitor cell implants in the lesioned medial longitudinal fascicle of adult cats regulate synaptic composition and firing properties of abducens internuclear neurons.

Camilo J Morado-Díaz et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(20), 7007-7017 (2014-05-16)

Transplants of neural progenitor cells (NPCs) into the injured CNS have been proposed as a powerful tool for brain repair, but, to date, few studies on the physiological response of host neurons have been reported. Therefore, we explored the effects

Valsartan reverses depressive/anxiety-like behavior and induces hippocampal neurogenesis and expression of BDNF protein in unpredictable chronic mild stress mice.

Gu Ping et al.

Pharmacology, biochemistry, and behavior, 124, 5-12 (2014-05-23)

Valsartan is a synthetic non-peptide angiotensin II type 1 receptor antagonist that dilates blood vessels and reduces blood pressure by blocking the action of angiotensin, and is safe and well tolerated in hypertensive patients. Population-based studies have suggested a positive

Conditional overexpression of insulin-like growth factor-1 enhances hippocampal neurogenesis and restores immature neuron dendritic processes after traumatic brain injury.

Shaun W Carlson et al.

Journal of neuropathology and experimental neurology, 73(8), 734-746 (2014-07-09)

Traumatic brain injury (TBI) is associated with neuronal damage or neuronal death in the hippocampus, a region critical for cognitive function. Immature neurons within the hippocampal neurogenic niche are particularly susceptible to TBI. Therapeutic strategies that protect immature hippocampal neurons

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