T3705

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显示 1-30 共 32 条结果关于 "T3705" 范围论文

Vitamin K antagonists favourably modulate fibrin clot properties in patients with atrial fibrillation as early as after 3days of treatment: Relation to coagulation factors and thrombin generation.

Michał Ząbczyk et al.

Thrombosis research, 136(4), 832-838 (2015-09-01)

Atrial fibrillation (AF) increases the risk of thromboembolism that is reduced by vitamin K antagonists (VKAs). We sought to investigate changes in plasma fibrin clot phenotype at the onset of oral anticoagulation. Forty consecutive AF patients (aged 45-83 years, CHA2DS2-VASc

Characterization of transferrin receptor-mediated endocytosis and cellular iron delivery of recombinant human serum transferrin from rice (Oryza sativa L.).

Deshui Zhang et al.

BMC biotechnology, 12, 92-92 (2012-12-01)

Transferrin (TF) plays a critical physiological role in cellular iron delivery via the transferrin receptor (TFR)-mediated endocytosis pathway in nearly all eukaryotic organisms. Human serum TF (hTF) is extensively used as an iron-delivery vehicle in various mammalian cell cultures for

Critical limb ischemia: thrombogenic evaluation of two autologous cell therapy products and biologic profile in treated patients.

Claire Tournois et al.

Transfusion, 55(11), 2692-2701 (2015-07-30)

Cell therapy has been proposed as a salvage limb procedure in critical limb ischemia (CLI). Autologous cell therapy products (CTP) are obtained from patients with advanced peripheral arterial disease to be injected at the site of ischemia. Thrombogenicity of CTPs

Increasing serum transferrin to reduce tissue iron overload due to ineffective erythropoiesis

Tolosano E

The Hematology Journal : The Official Journal of the European Haematology Association / EHA (2015)

C-reactive protein induces expression of tissue factor and plasminogen activator inhibitor-1 and promotes fibrin accumulation in vein grafts.

Y Ji et al.

Journal of thrombosis and haemostasis : JTH, 12(10), 1667-1677 (2014-08-02)

C-reactive protein (CRP) promotes tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) expression in vitro, and an elevated plasma CRP concentration is associated with an increased risk of vein graft (VG) thrombosis after coronary artery bypass surgery. However, little is known

Effect of phosphatidylinositol-3 kinase inhibition on ovotoxicity caused by 4-vinylcyclohexene diepoxide and 7, 12-dimethylbenz[a]anthracene in neonatal rat ovaries.

Aileen F Keating et al.

Toxicology and applied pharmacology, 241(2), 127-134 (2009-08-22)

4-vinylcyclohexene diepoxide (VCD) is an ovotoxicant that specifically destroys primordial and small primary follicles in the ovaries of mice and rats. In contrast, 7,12-dimethylbenz[a]anthracene (DMBA) is ovotoxic to all ovarian follicle classes. This study investigated phosphatidylinositol-3 kinase signaling involvement in

Coagulation activation in sickle cell trait: an exploratory study.

Chirag Amin et al.

British journal of haematology, 171(4), 638-646 (2015-10-30)

Recent epidemiologic data suggest that sickle cell trait (HbAS; AS) is a risk factor for venous thromboembolism. We conducted an exploratory study of healthy subjects with AS under baseline conditions to determine whether a chronic basal hyperactivation of coagulation exists

A remote-controlled immunochemical system for nephelometric detection of human serum transferrin

Strzelak K and Koncki R

Biosensors And Bioelectronics, 127(2), 31-37 (2019)

Platelet and not erythrocyte microparticles are procoagulant in transfused thalassaemia major patients.

Imane Agouti et al.

British journal of haematology, 171(4), 615-624 (2015-07-25)

The level of circulating platelet-, erythrocyte-, leucocyte- and endothelial-derived microparticles detected by high-sensitivity flow cytometry was investigated in 37 β-thalassaemia major patients receiving a regular transfusion regimen. The phospholipid procoagulant potential of the circulating microparticles and the microparticle-dependent tissue factor

Novel peptides that inhibit heparanase activation of the coagulation system.

E Axelman et al.

Thrombosis and haemostasis, 112(3), 466-477 (2014-07-18)

Heparanase is implicated in cell invasion, tumour metastasis and angiogenesis. It forms a complex and enhances the activity of the blood coagulation initiator - tissue factor (TF). We describe new peptides derived from the solvent accessible surface of TF pathway

Patient-Specific Induced Pluripotent Stem Cell Models: Generation and Characterization of Cardiac Cells.

Fabian Zanella et al.

Methods in molecular biology (Clifton, N.J.), 1353, 147-162 (2014-12-19)

The generation of human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes has been of utmost interest for the study of cardiac development, cardiac disease modeling, and evaluation of cardiotoxic effects of novel candidate drugs. Several protocols have been developed to guide

A hereditary bleeding disorder resulting from a premature stop codon in thrombomodulin (p.Cys537Stop).

Jonathan Langdown et al.

Blood, 124(12), 1951-1956 (2014-07-23)

In this study, we describe a novel thrombomodulin (TM) mutation (c.1611C>A) that codes for a change from cysteine 537 to a premature stop codon (p.Cys537Stop). Three members of a family with a history of posttraumatic bleeding were identified to be

Effect of human transferrin on the engraftment of allogeneic bone marrow in various strans of lethally irradiated mice.

Pierpaoli W.

Nature Immunology, 11, 356-365 (1992)

Transferrin-conjugated boron nitride nanotubes: protein grafting, characterization, and interaction with human endothelial cells.

Gianni Ciofani et al.

International journal of pharmaceutics, 436(1-2), 444-453 (2012-06-27)

In this paper we report on a covalent grafting of boron nitride nanotubes with human transferrin. After silanization of the nanotube wall, transferrin was linked to the nanotubes through carbamide binding. The obtained transferrin-conjugated boron nitride nanotubes (tf-BNNTs) resulted stable

Effect of transferrin, lactoferrin and chelated iron on human T-lymphocytes

Djeha A and Brock JH

British Journal of Haematology, 80(2), 235-241 (1992)

TFRC (transferrin receptor (p90, CD71))

Dorak MT

Atlas of Genetics and Cytogenetics in Oncology and Haematology (2009)

Nuclear phosphatidylcholine and sphingomyelin metabolism of thyroid cells changes during stratospheric balloon flight.

Elisabetta Albi et al.

Journal of biomedicine & biotechnology, 2009, 125412-125412 (2009-12-17)

Nuclear sphingomyelin and phosphatidylcholine metabolism is involved in the response to ultraviolet radiation treatment in different ways related to the physiological state of cells. To evaluate the effects of low levels of radiation from the stratosphere on thyroid cells, proliferating

Derivation of highly purified cardiomyocytes from human induced pluripotent stem cells using small molecule-modulated differentiation and subsequent glucose starvation

Sharma A, et al.

Journal of Visualized Experiments, (97) (2015)

Assays of fibrin network properties altered by VKAs in atrial fibrillation - importance of using an appropriate coagulation trigger.

Michal Ząbczyk et al.

Thrombosis and haemostasis, 113(4), 851-861 (2014-12-19)

Atrial fibrillation (AF) is a prothrombotic condition, involving increased thrombin generation and fibrinogen concentrations. Vitamin K antagonists (VKAs) prevent arterial thromboembolism if optimal anticoagulation is achieved by individualised drug doses, assessed by determining the Prothrombin time-related International Normalized Ratio (Pt-INR).

Changes in transferrin isoforms in pancreatic cancer

Gruszewska E, et al.

Annals of Clinical and Laboratory Science, 46(3), 286-290 (2016)

Expression, purification, and characterization of recombinant human transferrin from rice (Oryza sativa L.).

Deshui Zhang et al.

Protein expression and purification, 74(1), 69-79 (2010-05-08)

Transferrin is an essential ingredient used in cell culture media due to its crucial role in regulating cellular iron uptake, transport, and utilization. It is also a promising drug carrier used to increase a drug's therapeutic index via the unique

Binding of [Cr (phen) 3] 3+ to transferrin at extracellular and endosomal pHs: Potential application in photodynamic therapy

Garcia PF, et al.

Biochim. Biophys. Acta Gen. Subj., 1840(9), 2695-2701 (2014)

Biochemical and structural characterization of recombinant human serum transferrin from rice (Oryza sativa L.).

Ashley N Steere et al.

Journal of inorganic biochemistry, 116, 37-44 (2012-09-27)

The Fe(3+) binding protein human serum transferrin (hTF) is well known for its role in cellular iron delivery via the transferrin receptor (TFR). A new application is the use of hTF as a therapy and targeted drug delivery system for

High-efficient serum-free differentiation of endothelial cells from human iPS cells.

Sarkawt Hamad et al.

Stem cell research & therapy, 13(1), 251-251 (2022-06-12)

Endothelial cells (ECs) form the inner lining of all blood vessels of the body play important roles in vascular tone regulation, hormone secretion, anticoagulation, regulation of blood cell adhesion and immune cell extravasation. Limitless ECs sources are required to further

Asymmetric Notch activity by differential inheritance of lysosomes in human neural stem cells.

Bettina Bohl et al.

Science advances, 8(6), eabl5792-eabl5792 (2022-02-12)

Symmetric and asymmetric cell divisions are conserved strategies for stem cell expansion and the generation of more committed progeny, respectively. Here, we demonstrate that in human neural stem cells (NSCs), lysosomes are asymmetrically inherited during mitosis. We show that lysosomes

Effect of resection of localized pancreaticobiliary adenocarcinoma on angiogenic markers and tissue factor related pro-thrombotic and pro-angiogenic activity.

H H Echrish et al.

Thrombosis research, 134(2), 479-487 (2014-06-16)

In this study, 52 patients were studied to elucidate the relative impact of resection of localized pancreaticobiliary adenocarcinoma (PBC) on circulating factors of tumour-associated angiogenesis e.g. tissue factor bearing microparticles (TFMP) and vascular endothelial growth factor (VEGF) and their clinicopathological

NF-kappaB mediates mitogen-activated protein kinase pathway-dependent iNOS expression in human melanoma.

Deon G Uffort et al.

The Journal of investigative dermatology, 129(1), 148-154 (2008-08-01)

Tumor expression of inducible nitric oxide synthase (iNOS) predicts poor outcomes for melanoma patients. We have reported the regulation of melanoma iNOS by the mitogen-activated protein kinase (MAPK) pathway. In this study, we test the hypothesis that NF-kappaB mediates this

Chemically defined culture and cardiomyocyte differentiation of human pluripotent stem cells

Burridge PW, et al.

Current Protocols in Human Genetics / Editorial Board, Jonathan L. Haines ... [Et al.], 87(1), 21-23 (2015)

Known and potential roles of transferrin in iron biology

Bartnikas TB

Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, And Medicine, 25(4), 677-686 (2012)

Role of P-selectin and P-selectin glycoprotein ligand-1 interaction in the induction of tissue factor expression on human platelets after incubation with porcine aortic endothelial cells.

Mohamed B Ezzelarab et al.

Xenotransplantation, 21(1), 16-24 (2014-11-19)

Development of coagulation disorders remains a major challenge in pig-to-primate organ xenotransplantation. Our previous studies demonstrated that porcine aortic endothelial cells (pAEC) activate human platelets to express tissue factor (TF). In this study, we investigated the molecular interaction between human

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