CN
- Design of a cellular-uptake-shielding magnetic catcher for cancer cell separation.
Design of a cellular-uptake-shielding magnetic catcher for cancer cell separation.
Macromolecular bioscience (2012-09-12)
Ya Wang, Jing Zhang, Hui-Zhen Jia, Juan Yang, Si-Yong Qin, Chen-Wei Liu, Ren-Xi Zhuo, Xian-Zheng Zhang
PMID22965892
摘要
Fluorescent-magnetic-biotargeting multifunctional microcapsules (FMBMMs) are designed and fabricated via layer-by-layer assembly. It is found that the arginine-glycine-aspartate-modified FMBMMs were capable of sensitively detecting and efficiently isolating approximately 80% target cancer cells within 20 min. More importantly, FMBMMs present a general template for identifying and separating multiple types of cancer cells simply by altering the recognition motif.