Merck
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D1530

Sigma-Aldrich

1α,25-二羟基维生素D3

≥99% (HPLC)

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别名:
1α,25-二羟胆钙化醇, 骨化三醇
经验公式（希尔记法）:
C27H44O3
CAS号:
32222-06-3
分子量:
416.64
Beilstein:
7559394
EC 号:
250-963-8
MDL编号:
MFCD00867079
eCl@ss:
34058003
PubChem化学物质编号:
24893473
NACRES:
NA.79

质量水平

300

检测方案

≥99% (HPLC)

形式

solid

技术

HPLC: suitable

储存温度

−20°C

SMILES字符串

[H][C@@]1(CC[C@@]2([H])C(\CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C)[C@H](C)CCCC(C)(C)O

InChI

1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1

InChI key

GMRQFYUYWCNGIN-NKMMMXOESA-N

基因信息

human ... VDR(7421)

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相关类别

生化/生理作用

在钙的吸收和沉积中维生素D3的生物活性形式。 1α,25-二羟基维生素D3对细胞分化和增殖具有广泛的作用，并可调节免疫应答和中枢神经系统功能。最近的研究表明，1α,25-二羟基维生素D3可作为抵抗包括前列腺癌和结肠癌在内数种恶性肿瘤的化学预防剂，并显示出了与其他抗癌化合物的协同作用。
胆钙化醇是维生素D3的一种失活形式，它在经历各种水平的羟基化后可形成活性的维生素D3类似物。 1α-羟基维生素D3（阿法骨化醇是一种可代谢为1,25-二羟胆钙化醇的合成类似物，它是钙吸收和沉积中维生素D3的生物活性形式。1α,25-二羟基维生素D3对细胞分化和增殖具有广泛的作用，并可调节免疫应答和中枢神经系统功能。最近的研究表明，1α,25-二羟基维生素D3可作为抵抗包括前列腺癌和结肠癌在内数种恶性肿瘤的化学预防剂，并显示出了与其他抗癌化合物的协同作用。

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 1 Oral - Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - STOT RE 1

储存分类代码

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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示例

T1503
货号
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包装规格/数量

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705578-5MG-PW

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. How can I dissolve Product D1530, ?,25-Dihydroxyvitamin D3, for cell culture use?

    1?,25-Dihydroxyvitamin D3 is soluble in serveral organic solvents, including methanol, ethanol, ethyl acetate, and tetrahydrofuran. For cell culture use, a 10 μM stock solution can be prepared and diluted to the working concentration in cell culture media.

  6. What is the best way to store stock solutions of Product D1530, 1?,25-Dihydroxyvitamin D3?

    1?,25-Dihydroxyvitamin D3 is both air and light sensitive, so should be stored under inert gas at either -20 or -70°C.  The length of time a stock solution can be stored depends on how carefully air is excluded from the solution. If care is taken to exclude air, stock solutions may be stable indefinitely at -20°C.

  7. I can't see anything in the vial. How should Product D1530, 1´,25-Dihydroxyvitamin D3, look?

    D1530 is packaged by dispensing a solution into the vials, then drying them under inert gas. The product will be a thin film in the bottom of the vial, so it may appear to be empty by visual inspection.

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Maurizio Cutolo et al.
Vitamins and hormones, 86, 327-351 (2011-03-23)
Epidemiological evidence indicates a significant association between vitamin D deficiency and an increased incidence of autoimmune diseases. The presence of vitamin D receptors (VDRs) in the cells of the immune system and the fact that several of these cells produce
Maria Plesa et al.
Journal of asthma and allergy, 13, 249-264 (2020-09-29)
Airway fibroblasts are major contributors to the histopathological feature of airway remodeling in asthma by their implication in the cell invasiveness and profibrogenic secretory phenotype observed in subepithelial fibrosis. 1,25 Dihydroxy vitamin D3 (1,25(OH)2D3) is an important therapeutic agent that
Milos Cekic et al.
Neurobiology of aging, 32(5), 864-874 (2009-06-02)
Administration of the neurosteroid progesterone (PROG) has been shown to be beneficial in a number of brain injury models and in two recent clinical trials. Given widespread vitamin D deficiency and increasing traumatic brain injuries (TBIs) in the elderly, we
Moira Cheung et al.
The Journal of clinical endocrinology and metabolism, 98(5), E954-E961 (2013-03-28)
X-linked hypophosphatemic rickets is caused by mutations in PHEX. Even though the disease is characterized by disordered skeletal mineralization, detailed bone densitometric studies are lacking. The aim of the study was to assess volumetric bone mineral density (vBMD) in X-linked
Lisa Asano et al.
FEBS letters, 587(7), 957-963 (2013-03-07)
Non-secosteroidal ligands for vitamin D receptor (VDR) have been developed for the agonist with non-calcemic profiles. Here, we provide the structural mechanism of VDR agonism by novel non-secosteroidal ligands. All ligands had the similar efficacy, while two had the higher
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Vitamin D and Prevention of Human Disease

Vitamin D2 (ergocalciferol) is naturally synthesized from ergosterol by invertebrates, fungi, and plants in response to ultraviolet B irradiation, while vitamin D3 synthesis (cholecalciferol) is uniquely initiated in the skin of vertebrates. During sun exposure, ultraviolet B photons are absorbed by 7-dehydrocholesterol, which is found within the plasma membranes of epidermal and dermal skin layers. This reaction yields an unstable derivative of 7-dehydrocholesterol, named precholecalcitrol, which rapidly rearranges to vitamin D3. Vitamin D binding protein (DBP) is a carrier protein responsible for drawing vitamin D3 from the plasma membrane into the dermal capillaries within the extracellular space.

Vitamin D and Prevention of Human Disease

Vitamin D2 (ergocalciferol) is naturally synthesized from ergosterol by invertebrates, fungi, and plants in response to ultraviolet B irradiation, while vitamin D3 synthesis (cholecalciferol) is uniquely initiated in the skin of vertebrates. During sun exposure, ultraviolet B photons are absorbed by 7-dehydrocholesterol, which is found within the plasma membranes of epidermal and dermal skin layers. This reaction yields an unstable derivative of 7-dehydrocholesterol, named precholecalcitrol, which rapidly rearranges to vitamin D3. Vitamin D binding protein (DBP) is a carrier protein responsible for drawing vitamin D3 from the plasma membrane into the dermal capillaries within the extracellular space.

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