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PRS4203

Anti-Presenilin1 antibody produced in rabbit

Name: Anti-Presenilin1 antibody produced in rabbit
Brand: SIGMA

affinity isolated antibody, buffered aqueous solution

别名:

Anti-γ-Secretase subunit presenilin-1, Anti-PS1, Anti-PSEN1, Anti-Presenilin 1

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关于此项目

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD01634040

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ELISA (i), IF, IHC, WB

Citations:

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属性

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, rat, human

technique(s)

immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable

UniProt accession no.

P49768

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PSEN1(5663)

说明

Immunogen

a 23 amino acid peptide from near the carboxy-terminus of human presenilin1.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Other Notes

The action of this antibody can be blocked using blocking peptide SBP4203.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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存储类别

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

低风险生物材料

常规特殊物品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

42030702

4203-0702

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Characterization of AD-like phenotype in aged APPSwe/PS1dE9 mice.

Huang Huang et al.

Age (Dordrecht, Netherlands), 38(4), 303-322 (2016-07-22)

Transgenic APPSwe/PS1dE9 (APP/PS1) mice that overproduce amyloid beta (Aβ) are extensively used in the studies of pathogenesis and experimental therapeutics and new drug screening for Alzheimer's disease (AD). However, most of the current literature uses young or adult APP/PS1 mice.

Enriched physical environment reverses spatial cognitive impairment of socially isolated APPswe/PS1dE9 transgenic mice before amyloidosis onset.

Min Cao et al.

CNS neuroscience & therapeutics, 24(3), 202-211 (2017-12-24)

Social isolation increases the onset of Alzheimer's disease (AD). Environmental enrichment, a complicated social and physical construct, plays beneficial effects on brain plasticity and function. This study was designed to determine whether physical enrichment can reduce the deleterious consequences of social

Microglia prevent beta-amyloid plaque formation in the early stage of an Alzheimer's disease mouse model with suppression of glymphatic clearance.

Weixi Feng et al.

Alzheimer's research & therapy, 12(1), 125-125 (2020-10-04)

Soluble beta-amyloid (Aβ) can be cleared from the brain through various mechanisms including enzymatic degradation, glial cell phagocytosis, transport across the blood-brain barrier, and glymphatic clearance. However, the relative contribution of each clearance system and their compensatory effects in delaying

全球贸易项目编号

货号	GTIN
SBP4203-0.05MG	04061832163192
PRS4203-100UG	04061832179056