Stabilize Biomolecules with Excipients

WEBINAR

A stable formulation is critical to ensure the desired therapeutic activity and safety of biologics. Mechanical stresses during manufacturing and transportation and certain storage conditions can lead to protein destabilization and aggregation. By minimizing interface interactions and increasing solubility, surfactants can stabilize proteins. Polysorbates have been the most widely used surfactants in biologics due to their biocompatibility and low toxicity. However, over the past decade challenges associated with the stability of polysorbates have been encountered. To reduce these quality issues, alternative surfactants, such as poloxamer 188 are considered in biomolecule formulations.

In this webinar, you will learn:

• The role of surfactants as stabilizers in biopharmaceuticals
• The advantages/disadvantages of using the various marketed surfactant in biomolecule surfactants
• The impacts of impurities in excipients on the formulation stability