High Concentration Ultrafiltration: Formulation Challenges & Mitigation Strategies

WEBINAR

Tangential flow filtration (TFF) using ultrafiltration membranes is commonly used for the final formulation and concentration of monoclonal antibodies. Injection of liquid formulations is often the preferred method of administration for these therapeutics. In cases where high dosages are required, manufacturers frequently target high concentration liquid formulations which can result in high viscosity solutions. Highly concentrated protein solutions have challenges associated with formulation. This webinar presents the formulation challenges that are associated with plausible risk mitigation strategies to overcome such formulation challenges.

In this webinar you will learn about:

• High concentration UF-DF optimization
• Scaling up the UF-DF step
• Models to explain buffer offsets
• Process Development to mitigate buffer offsets