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880135P

Avanti

DSPE-PEG(2000) Carboxylic Acid

Avanti Polar Lipids 880135P, powder

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Synonym(s):
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)-2000] (sodium salt)
Empirical Formula (Hill Notation):
C131H257NNaO55P
CAS Number:
1403744-37-5
Molecular Weight:
2780.38
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 10 mg (880135P-10mg)
pkg of 1 × 100 mg (880135P-100mg)
pkg of 1 × 25 mg (880135P-25mg)
pkg of 1 × 50 mg (880135P-50mg)
pkg of 1 × 500 mg (880135P-500mg)

manufacturer/tradename

Avanti Polar Lipids 880135P

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCCNC(C/C=C\OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOCCOOCC(O)=O)=O)=O)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=

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General description

Carboxylic acids are readily soluble in polar solvents such as water and alcohols. DSPE-PEG(2000) carboxylic acid consists of a hydrophilic polyethylene glycol (PEG) chain of 2kDa.

Application

DSPE-PEG(2000) carboxylic acid has been used:
  • to covalently conjugate integrin α-2 (ITGA2) antibodies to the surface of the liposomes
  • in the preparation of atosiban-conjugated liposomes
  • to prepare dual complementary liposome

Biochem/physiol Actions

DSPE-PEG(2000) carboxylic acid increases the blood circulation time of liposomes. The carboxyl group of DSPE-PEG(2000) carboxylic acid aids in covalent conjugation with antibodies.

Packaging

20 mL Clear Glass Screw Cap Vial (880135P-500mg)
5 mL Amber Glass Screw Cap Vial (880135P-100mg)
5 mL Amber Glass Screw Cap Vial (880135P-10mg)
5 mL Amber Glass Screw Cap Vial (880135P-25mg)
5 mL Amber Glass Screw Cap Vial (880135P-50mg)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

No data available

Flash Point(C)

No data available

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Dual complementary liposomes inhibit triple-negative breast tumor progression and metastasis
Guo P, et al.
Science advances, 5(3), eaav5010-eaav5010 (2019)
ITGA2 as a potential nanotherapeutic target for glioblastoma
Guo P, et al.
Scientific reports, 9(1), 6195-6195 (2019)
Mohammad Mashreghi et al.
Nanoscale research letters, 15(1), 101-101 (2020-05-10)
In this study, we have surface-functionalized PEGylated-nanoliposomal doxorubicin (DOX) with anti-EpCAM (epithelial cell adhesion molecule) aptamer via post-insertion of anti-EpCAM aptamer-conjugated DSPE-mPEG2000 into Caelyx® (ED-lip). The size, charge, release profile, and cytotoxicity and cellular uptake of formulation were determined. The
Feifei Yang et al.
Small (Weinheim an der Bergstrasse, Germany), 16(7), e1906360-e1906360 (2020-01-24)
Hepatotoxicity is a key concern in the clinical translation of nanotherapeutics because preclinical studies have consistently shown that nanotherapeutics accumulates extensively in the liver. However, clinical-stage nanotherapeutics have not shown increased hepatotoxicity. Factors that can contribute to the hepatotoxicity of
Anujan Ramesh et al.
Nanoscale, 12(3), 1875-1885 (2020-01-07)
Tumor associated macrophages (TAMs) play an important role in initiating the immunosuppressive environment that negatively impacts the immunotherapy efficacy and has long been linked with cancer progression. On the other hand, activated macrophages display immense phagocytic potential and can be
View All Related Papers

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