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Merck
CN

D0718000

Dexamethasone pivalate

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Dexamethasone 21-trimethylacetate, 9-Fluoro-11β,17-dihydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-yl 2,2-dimethylpropanoate

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About This Item

Empirical Formula (Hill Notation):
C27H37FO6
CAS Number:
Molecular Weight:
476.58
MDL number:
UNSPSC Code:
41116107
NACRES:
NA.24
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grade

pharmaceutical primary standard

API family

dexamethasone

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

F[C@@]21[C@H]([C@H]4[C@@]([C@@]([C@@H](C4)C)(O)C(=O)COC(=O)C(C)(C)C)(C[C@@H]2O)C)CCC3=CC(=O)C=C[C@@]31C

InChI

1S/C27H37FO6/c1-15-11-19-18-8-7-16-12-17(29)9-10-24(16,5)26(18,28)20(30)13-25(19,6)27(15,33)21(31)14-34-22(32)23(2,3)4/h9-10,12,15,18-20,30,33H,7-8,11,13-14H2,1-6H3/t15-,18+,19+,20+,24+,25+,26+,27+/m1/s1

InChI key

XMQRFWOHEPJZPS-JHUFMRCFSA-N

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Dexamethasone pivalate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.


Regulatory Information

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R J Fairclough et al.
Australian journal of biological sciences, 34(3), 313-319 (1981-01-01)
A radioimmunoassay has been developed for the measurement of dexamethasone in plasma and milk of cows injected with long- and short-acting dexamethasone esters. Dexamethasone antiserum was produced by injecting cows with a dexamethasone-21-hemisuccinate-human serum albumin complex. The antisera was highly
The effect of glucocorticoids and prematurity on absorption of colostral immunoglobulin in the calf.
N E Johnston et al.
Australian veterinary journal, 63(6), 191-192 (1986-06-01)
Betamethasone dipropionate (0.05%) plus salicylic acid (3%) ointment versus dexamethasone trimethyl acetate (1%) and salicylic acid 4% ointments in chronic dermatoses.
S P Chattopadhyay et al.
Indian journal of dermatology, 32(2), 41-44 (1987-04-01)



Global Trade Item Number

SKUGTIN
D071800004061833558010