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PHR1232

Calcium-d-pantothenate

Name: Calcium-d-pantothenate
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

D-Pantothenic acid hemicalcium salt, (R)-(+)-N-(2,4-Dihydroxy-3,3-dimethyl-1-oxobutyl)-β-alanine hemicalcium salt, Calcium D-pantothenate, Vitamin B₅

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About This Item

Linear Formula:

HOCH₂C(CH₃)₂CH(OH)CONHCH₂CH₂CO₂ ·1/2Ca

CAS Number:

137-08-6

Molecular Weight:

238.27

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329823237

EC Number:

205-278-9

Beilstein/REAXYS Number:

3769272

MDL number:

MFCD00002766

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Properties

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. C0400000, traceable to USP 1087009

API family

calcium pantothenate

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CC(C)(CO)[C@@H](O)C(=O)NCCC(=O)O[Ca]OC(=O)CCNC(=O)[C@H](O)C(C)(C)CO

InChI

1S/2C9H17NO5.Ca/c2*1-9(2,5-11)7(14)8(15)10-4-3-6(12)13;/h2*7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13);/q;;+2/p-2/t2*7-;/m00./s1

InChI key

FAPWYRCQGJNNSJ-UBKPKTQASA-L

Description

General description

Due to the unstable, hygroscopic nature of the free acid, the calcium salt is employed.

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Calcium-d-pantothenate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by ion chromatography.

Precursor in the biosynthesis of coenzyme A.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAB3618 in the slot below. This is an example certificate only and may not be the lot that you receive.

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Articles

Determination of Vitamin B5 in dairy products

Extract pantothenic acid (vitamin B5) from infant formula and quantify via LC-MS/MS using Ascentis^® Express C18 UHPLC column per GB 5009.210-2023.

Carbon dioxide (CO2) levels this century will alter the protein, micronutrients, and vitamin content of rice grains with potential health consequences for the poorest rice-dependent countries.

Chunwu Zhu et al.

Science advances, 4(5), eaaq1012-eaaq1012 (2018-05-29)

Declines of protein and minerals essential for humans, including iron and zinc, have been reported for crops in response to rising atmospheric carbon dioxide concentration, [CO2]. For the current century, estimates of the potential human health impact of these declines

Dietary supplements containing vitamins and minerals: Formulation, optimization and evaluation

Rajakumari R, et al.

Powder Technology, 336, 481-492 (2018)

Performance of Broiler Chickens Fed Low Protein, Limiting Amino Acid Supplemented Diets Formulated Either on Total or Standardized Ileal Digestible Amino Acid Basis.

C Basavanta Kumar et al.

Asian-Australasian journal of animal sciences, 29(11), 1616-1624 (2016-10-27)

The aim of present experiment was to investigate the effect of protein reduction in commercial broiler chicken rations with incorporation of de-oiled rice bran (DORB) and supplementation of limiting amino acids (valine, isoleucine, and/or tryptophan) with ration formulation either on

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Global Trade Item Number

SKU	GTIN
PHR1232-500MG	04061835237708