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PHR1611

Mercaptopurine

Name: Mercaptopurine
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

6-Mercaptopurine monohydrate, 6-Purinethiol, 6-Thiohypoxanthine

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About This Item

Empirical Formula (Hill Notation):

C₅H₄N₄S·H₂O

CAS Number:

6112-76-1

Molecular Weight:

170.19

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329823508

EC Number:

200-037-4

Beilstein/REAXYS Number:

4012091

MDL number:

MFCD03854445

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Properties

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to USP 1392002

API family

mercaptopurine

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

O.S=C1NC=Nc2nc[nH]c12

InChI

1S/C5H4N4S.H2O/c10-5-3-4(7-1-6-3)8-2-9-5;/h1-2H,(H2,6,7,8,9,10);1H2

InChI key

WFFQYWAAEWLHJC-UHFFFAOYSA-N

Gene Information

human ... PPAT(5471)

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Mercaptopurine is an anticancer and an immunosuppressive drug employed for the management of acute lymphocytic leukemia (ALL), chronic myeloid leukemia (CML), Crohn′s disease, etc. Its mode of action involves interference in the nucleic acid synthesis by the inhibition of purine metabolism.

Application

Mercaptopurine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations, suspensions, and double drug liposomes by chromatography.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAC3476 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

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pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301,H341,H361fd

pcodes

P202 - P264 - P280 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral - Muta. 2 - Repr. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Global Trade Item Number

SKU	GTIN
PHR1611-1G	04061834623892