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PHR1886

Memantine Hydrochloride

Name: Memantine Hydrochloride
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Memantine hydrochloride, 3,5-Dimethyl-1-adamantanamine hydrochloride, 3,5-Dimethylamantadine hydrochloride, 3,5-Dimethyltricyclo[3.3.1.1^3,7]decan-1-amine hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₂H₂₁N · HCl

CAS Number:

41100-52-1

Molecular Weight:

215.76

NACRES:

NA.24

PubChem Substance ID:

329823633

UNSPSC Code:

41116107

EC Number:

255-219-6

MDL number:

MFCD00214336

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Properties

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to USP 1380502

API family

memantine

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Cl.C[C@]12CC3C[C@](C)(C1)CC(N)(C3)C2

InChI

1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H/t9-,10+,11-,12-;

InChI key

LDDHMLJTFXJGPI-VXMZOEJHSA-N

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Memantine Hydrochloride is a drug used for treating the Alzheimer′s disease by means of reducing abnormal activity in the brain. It can help patients suffering from dementia as it assists them to think more clearly and perform their chores with ease.

Application

Memantine Hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometry and gas chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAB9158 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Determination of memantine hydrochloride by spectrophotometry using anionic dyes, bromothymol blue and solochrome black T, in bulk and tablet dosage forms.

Rani AP, et al.

Chemical Science (2012)

Development and validation of stability-indicating GC-FID method for the quantitation of memantine hydrochloride and its nonchromophoric impurities in bulk and pharmaceutical dosages.

Jadhav SA, et al.

Chromatography Research International (2012)

Global Trade Item Number

SKU	GTIN
PHR1886-1G	04061835220557