Skip to Content
Merck
CN

Key Documents

View All Documentation

D7910

3,4-Dichloroisocoumarin

≥98% (TLC), Serine protease inhibitor, powder

Synonym(s):

3,4-DCI, 3,4-Dichloro-2-benzopyran-1-one

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):
C9H4Cl2O2
CAS Number:
51050-59-0
Molecular Weight:
215.03
NACRES:
NA.77
PubChem Substance ID:
24278386
UNSPSC Code:
12352202
MDL number:
MFCD00036960
Beilstein/REAXYS Number:
6802625
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

3,4-Dichloroisocoumarin, serine protease inhibitor

Quality Level

200

assay

≥98% (TLC)

form

powder

solubility

ethyl acetate: 49.00-51.00 mg/mL, clear, colorless to faintly yellow

storage temp.

2-8°C

SMILES string

ClC1=C(Cl)c2ccccc2C(=O)O1

InChI

1S/C9H4Cl2O2/c10-7-5-3-1-2-4-6(5)9(12)13-8(7)11/h1-4H

InChI key

SUGXUUGGLDCZKB-UHFFFAOYSA-N

General description

Serine protease inhibitor. Active towards a wide range of serine proteases including granzymes. Not active toward β-lactamases.

Application

Useful in a rapid staining method for identification of macrophages; counts by this method were confirmed by the more complex morphological criteria, by phagocytosis, and by the presence of Fc receptors.

Preparation Note

Half-life = 20 min at pH 7.5.

Other Notes

Effective concentration 5-100 μM.

Still not finding the right product?

Explore all of our products under 3,4-Dichloroisocoumarin

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Articles

半胱氨酸蛋白酶——木瓜蛋白酶的特性和产品

木瓜蛋白酶是肽酶C1家族的一种半胱氨酸蛋白酶。它由单一多肽链组成，含有三个二硫键和一个酶活性所必需的巯基。

Elastase Function and Importance

Elastase application index for understanding leukocyte elastase, a 29KDa serine endoprotease.

Papain, Cysteine Protease, Properties & Products

Uncover properties and applications of the cysteine protease papain and find inhibitors, substrates, and other papain products.