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N7389

3-Nitro-L-tyrosine

Name: 3-Nitro-<SC>L</SC>-tyrosine
Brand: SIGMA

Oxidant, crystalline

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About This Item

Linear Formula:

O₂NC₆H₃-4-(OH)CH₂CH(NH₂)CO₂H

CAS Number:

621-44-3

Molecular Weight:

226.19

NACRES:

NA.32

PubChem Substance ID:

24897825

eCl@ss:

32160406

UNSPSC Code:

12352200

EC Number:

210-688-6

MDL number:

MFCD00007123

Beilstein/REAXYS Number:

2813157

Form:

crystalline

Quality level:

200

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Properties

Product Name

3-Nitro-L-tyrosine, crystalline

form

crystalline

Quality Level

200

mp

233-235 °C (dec.) (lit.)

SMILES string

N[C@@H](Cc1ccc(O)c(c1)[N+]([O-])=O)C(O)=O

InChI

1S/C9H10N2O5/c10-6(9(13)14)3-5-1-2-8(12)7(4-5)11(15)16/h1-2,4,6,12H,3,10H2,(H,13,14)/t6-/m0/s1

InChI key

FBTSQILOGYXGMD-LURJTMIESA-N

Description

Application

3-Nitro-L-tyrosine has been used in:

western blot analysis to quantify the nitrotyrosine levels in mice tissue protein
Murashige–Skoog medium to treat wild type and mitogen-activated protein kinase 6 (mpk6)-2 mutant seedlings for inferring the connection between nitric oxide (NO) and MPK6 functions in the regulation of mitotic microtubule organization
immunocytochemistry

Biochem/physiol Actions

3-Nitro-L-tyrosine is an oxidant and cytotoxic agent. 3-Nitrotyrosine serves as a biological marker of proteins modified by nitrogen-free radical species in systemic autoimmunogenic conditions. It is a marker for oxidative damage mediated by peroxynitrite. Nitrotyrosine is associated with VEGF-C expression and lymph node metastasis in breast cancer. 3-Nitrotyrosine is produced due to oxidative/nitrosative stress-mediated chemical modifications such as nitration of proteins, which is observed in lung carcinogenesis.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Global Trade Item Number

SKU	GTIN
N7389-25G	04061833631157
N7389-10G	04061833631140
N7389-5G	04061834118008