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Merck
CN

P0098

Pediocin from Pediococcus acidilactici

≥95% (HPLC), buffered aqueous solution

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About This Item

CAS Number:
NACRES:
NA.85
UNSPSC Code:
51102829
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Quality Level

assay

≥95% (HPLC)

form

buffered aqueous solution

concentration

0.1 mg/mL in 0.1 M sodium acetate pH 5.0

antibiotic activity spectrum

Gram-positive bacteria

mode of action

cell membrane | interferes

shipped in

dry ice

storage temp.

−20°C

General description

Chemical structure: peptide

Application

Pediocins have molecular masses of about 2,700 to 4,000 Da. They are potential food biopreservatives used to control food-borne pathogens and spoilage.

Biochem/physiol Actions

Pediocins are class IIa bacteriocins that are produced by Pediococcus acidilactici. They are cationic peptides with molecular masses of about 2,700 to 4,000 Da, that show strong activity against pathogenic bacteria such as Listeria monocytogenes, Clostridicum perfringes, Enterococcus faecalis, and Staphylococcus aureus.4 This antimicrobial action of pediocins is based on interactions with the cytoplasmic membrane, resulting in pore formation and cell death. These interactions also cause a change in membrane potentials, which leads to a loss of the proton motive force and an efflux of intracellular ions, ultimately causing cell death. They have been shown to inhibit Listeria monocytogenes.

Other Notes

50ug
Keep container tightly closed in a dry and well-ventilated place.


Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Information

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Articles

由于细菌耐药性和新出现的传染病成为人类的潜在威胁,核糖体合成的抗菌肽已成为抗生素研究的一个有前途的重点领域。

Ribosomally synthesized antimicrobial peptides are a promising focus in antibiotic research amidst bacterial resistance and emerging infectious diseases.

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