S0625
D-(−)-Salicin
≥99% (GC)
Synonym(s):
2-(Hydroxymethyl)phenyl-β-D-glucopyranoside, Salicoside, Salicyl alcohol glucoside, Saligenin β-D-glucoside
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About This Item
Empirical Formula (Hill Notation):
C13H18O7
CAS Number:
Molecular Weight:
286.28
UNSPSC Code:
12352205
NACRES:
NA.25
PubChem Substance ID:
EC Number:
205-331-6
Beilstein/REAXYS Number:
89593
MDL number:
Quality Level
assay
≥99% (GC)
form
powder
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
SMILES string
OC[C@H]1O[C@@H](Oc2ccccc2CO)[C@H](O)[C@@H](O)[C@@H]1O
InChI
1S/C13H18O7/c14-5-7-3-1-2-4-8(7)19-13-12(18)11(17)10(16)9(6-15)20-13/h1-4,9-18H,5-6H2/t9-,10-,11+,12-,13-/m1/s1
InChI key
NGFMICBWJRZIBI-UJPOAAIJSA-N
General description
Salicin is a non-phenolic glucosidic compound extracted from meadowsweet (Filipendula ulmaria L). It is majorly used as a substitute for quinine. Salicin can be used as a therapeutic for patients suffering from rheumatic fever. Salicin acts a metabolic precursor for salicylic acid. It is a novel phytochemical that exhibits immunological cross functions in plants and humans. Salicin facilitates growth and reproduction in plants. In addition, It also protects plants against biotic and abiotic stress.
Application
D-(-)-Salicin has been used:
- to study its in vitro anticoagulant and antiplatelet activities
- as a standard in high performance liquid chromatography method (HPLC) for quantitation of salicin from willow plant
- as a tastant in taste threshold assay
- as a constituent of nutrient agar-salicin medium for selective isolation of Lactobacillus paracasei
Biochem/physiol Actions
D-(−)-Salicin exerts anti-rheumatism and anti-inflammatory activities. It inhibits lipopolysaccharide (LPS) induced inflammation in in vitro and in vivo studies. It regulates different signaling pathways such as nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK). It also regulates cytokines concentration such as tumor necrosis factor-alpha(TNF-α), interleukin-1β, interleukin-6, and interleukin-10.
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signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Development and Validation of HPLC Analytical Protocol for Quantification of Salicin from Salix alba L.
Shivatare RS, et al.
Pharmaceutica Analytica Acta, 61, 2015-2015 (2015)
Evaluation of culture media for selective enumeration of probiotic strains of lactobacilli and bifidobacteria in combination with yoghurt or cheese starters
Van de Casteele S, et al.
International dairy journal, 16(12), 1470-1476 (2006)
Biosynthesis and metabolism of beta-D-salicin: a novel molecule that exerts biological function in humans and plants
Mahdi, Jassem G
Biotechnology reports (Amsterdam, Netherlands), 4, 73-79 (2014)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| S0625-5G | 04061836830403 |
| S0625-100G | 04061836830342 |
| S0625-10G | 04061835327287 |
| S0625-25G | 04061835327294 |