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T5251

D-(+)-Trehalose dihydrate

Name: <SC>D</SC>-(+)-Trehalose dihydrate
Brand: SIGMA

≥98.5% (HPLC), from Saccharomyces cerevisiae

Synonym(s):

α,α-Trehalose dihydrate, D-Trehalose dihydrate, α,α-Trehalose, α-D-Glucopyranosyl-α-D-glucopyranoside

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About This Item

Empirical Formula (Hill Notation):

C₁₂H₂₂O₁₁ · 2H₂O

CAS Number:

6138-23-4

Molecular Weight:

378.33

UNSPSC Code:

12352201

NACRES:

NA.25

PubChem Substance ID:

57654674

EC Number:

202-739-6

Beilstein/REAXYS Number:

5322018

MDL number:

MFCD00071594

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Properties

biological source

Saccharomyces cerevisiae

Quality Level

300

assay

≥98.5% (HPLC)

form

powder

optical activity

[α]/D 174 to 182 °, c = 1.0% (w/v) in water

technique(s)

HPLC: suitable, cryopreservation: suitable

mp

97-99 °C

application(s)

agriculture
cell analysis
genomic analysis
life science and biopharma

SMILES string

[H]O[H].[H]O[H].OC[C@H]1O[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C12H22O11.2H2O/c13-1-3-5(15)7(17)9(19)11(21-3)23-12-10(20)8(18)6(16)4(2-14)22-12;;/h3-20H,1-2H2;2*1H2/t3-,4-,5-,6-,7+,8+,9-,10-,11-,12-;;/m1../s1

InChI key

DPVHGFAJLZWDOC-PVXXTIHASA-N

Description

General description

D-(+)-Trehalose, a disaccharide, acts as a chemical chaperone and serves as a carbohydrate reserve in microorganisms. It functions as an osmolyte, safeguarding cells against various environmental stresses. Further, it also plays a crucial role in protein stabilization during freeze drying, making it a valuable asset in the areas of biochemical, cell culture, and excipient research

Application

Use as a cryoprotectant in a variety of cell freezing media
Used in excipeint research

Biochem/physiol Actions

Trehalose is a non-reducing sugar formed from two glucose units joined by a 1-1 alpha bond. It is thought to provide plants and animals with the ability to withstanding periods of dehydration.

Features and Benefits

Prepared from Saccharomyces cerevisiae
Suitable for use with HPLC and GC-MS(4)

Preparation Note

Prepared by the modified procedure of Payen, R., Can. J. Res., 27B, 749 (1949).

Other Notes

To gain a comprehensive understanding of our extensive range of Disaccharides for your research, we encourage you to visit our Carbohydrates Category page.

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Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品

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The Inclusion of Chitosan in Poly-ε-caprolactone Nanoparticles: Impact on the Delivery System Characteristics and on the Adsorbed Ovalbumin Secondary Structure.

Sandra Jesus et al.

AAPS PharmSciTech, 19(1), 101-113 (2017-06-15)

This report extensively explores the benefits of including chitosan into poly-ε-caprolactone (PCL) nanoparticles (NPs) to obtain an improved protein/antigen delivery system. Blend NPs (PCL/chitosan NPs) showed improved protein adsorption efficacy (84%) in low shear stress and aqueous environment, suggesting that

Measurement of shrinkage and cracking in lyophilized amorphous cakes, part 3: hydrophobic vials and the question of adhesion.

Sabine Ullrich et al.

Journal of pharmaceutical sciences, 104(6), 2040-2046 (2015-04-03)

The importance of cake adhesion to the inside vial wall during lyophilization of amorphous trehalose cakes was determined by using hydrophobized vials. The degrees of cake shrinkage and cracking were determined independently by photographic imaging of the cake top surface

Microheterogeneity in frozen protein solutions.

Alan Twomey et al.

International journal of pharmaceutics, 487(1-2), 91-100 (2015-04-19)

In frozen and lyophilized systems, the biological to be stabilized (e.g. therapeutic protein, biomarker, drug-delivery vesicle) and the cryo-/lyo-protectant should be co-localized for successful stabilization. During freezing and drying, many factors cause physical separation of the biological from the cryo-/lyo-protectant

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Global Trade Item Number

SKU	GTIN
T5251-100G	04061837347276
T5251-25G	04061837347306
T5251-10G	04061837347283
T5251-250G	04061837347290