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F3917

Forskolin

Name: Forskolin
Brand: SIGMA

For use in molecular biology applications

Synonym(s):

7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one, Coleonol, Colforsin

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₃₄O₇

CAS Number:

66575-29-9

Molecular Weight:

410.50

UNSPSC Code:

12352200

NACRES:

NA.52

PubChem Substance ID:

24894799

EC Number:

266-410-9

Beilstein/REAXYS Number:

1692716

MDL number:

MFCD00082317

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

200

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Properties

biological source

Coleus forskohlii

Quality Level

200

description

for activation of T cells

product line

BioReagent

assay

≥98% (HPLC)

form

powder

mol wt

410.50 g/mol

color

white to off-white

solubility

ethanol: soluble

suitability

suitable for inhibits interleukin 2 (IL-2) production in Jurkat cells

storage temp.

room temp

SMILES string

CC(=O)O[C@H]1[C@@H](O)[C@H]2C(C)(C)CC[C@H](O)[C@]2(C)[C@@]3(O)C(=O)C[C@@](C)(O[C@]13C)C=C

InChI

1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1

InChI key

OHCQJHSOBUTRHG-KGGHGJDLSA-N

Description

General description

Forskolin is a cell permeable diterpenoid isolated from Coleus forskohlii.

Biochem/physiol Actions

Cell-permeable diterpenoid that possesses anti-hypertensive, positive inotropic, and adenylyl cyclase activating properties. Many of its biological effects are due to its activation of adenylyl cyclase and the resulting increase in intracellular cAMP concentration. Forskolin effects calcium currents and inhibits MAP kinase.

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pictograms

GHS07

signalword

Warning

hcodes

H312

pcodes

P280 - P302 + P352 + P312 - P362 + P364 - P501

Hazard Classifications

Acute Tox. 4 Dermal

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Protocols

Forskolin-Induced Swelling Assays using Millicell^® Microwell Plates

Learn how to cultivate similar-sized iPSC-derived colon organoids using Millicell^® Microwell plates and perform a forskolin-induced swelling assay.