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Lipids for Therapeutics and Research

Abstract illustration of lipids’ hydrophobic tails projecting inwards and polar head groups projecting outwards to form cell membrane.

Lipids and their metabolism play a crucial role in the physiology of cells, tissues, and organs. Lipids are a diverse group of hydrophobic or amphiphilic compounds that are soluble in nonpolar organic solvents and insoluble in water. There are eight major categories of lipids based on their physical properties, such as solubility and polarity: fatty acids and acyls, glycerolipids, glycerophospholipids (GPLs), sphingolipids, sterol lipids, prenol lipids, saccharolipids, and polyketides. These molecules provide structure to cellular membranes, store energy, and are vital in cell signaling and in regulating cell functions.

Many inherited metabolic diseases are caused by defects in lipid metabolism. Lipid metabolism disorders often result from a harmful accumulation of unusual lipids in the blood and tissues of affected patients that can lead to damage in cells. The correct identification of these lipids is vital for proper diagnosis and treatment. Lipidomics research, a sub-discipline of metabolomics research, involves the profiling, identification and quantification of lipids within a biological source, and their interactions with other cellular components.

Promising therapeutic approaches are being developed with our wide range of lipids. We support rapid advances in metabolic pathway research and lipid applications along the entire lipidomics workflow, from sample collection, storage and extraction to analytical calibration, analysis and data processing. Browse our extensive listing of products for steroids, prostaglandins, saturated and unsaturated fatty acids, and oils.

Lipids in Cell Culture

Lipids such as cholesterol can be used to supplement cell culture media where animal-derived components must be avoided. Cholesterol formulated with methyl-beta-cyclodextrin demonstrates enhanced solubility in water, a property necessary for the inclusion of cholesterol as a medium supplement. We are the only commercial supplier of synthetic cholesterol, and also offer a mixture of fatty acids for the optimization of CHO cell growth in serum-free medium.

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Product Number

Product Name

Product Description

Pricing

G5516

Glycerol

for molecular biology, ≥99.0%

CRM47885

Supelco 37 Component FAME Mix

certified reference material, TraceCERT^®, in dichloromethane (varied conc.), ampule of 1 mL

Glycerol

Cholesterol

Oleic acid

Oleic acid

Palmitic acid

Glycerol

L-α-Phosphatidylcholine

egg yolk, Type XVI-E, ≥99% (TLC), lyophilized powder

L1376

Linoleic acid

≥99%

18919-1AMP

F.A.M.E. Mix, C4-C24

certified reference material, wt. % (varied)

18512

Paraffin oil

puriss., meets analytical specification of Ph. Eur., BP, viscous liquid

A6625

Acetylcholine chloride

≥99% (TLC)

O3008

Oleic Acid-Albumin from bovine serum

liquid, sterile-filtered, BioReagent, suitable for cell culture

850365P

18:0 PC (DSPC)

Avanti Polar Lipids

G2025

Glycerol

BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for electrophoresis, ≥99% (GC)

175366

Stearic acid

reagent grade, 95%

C3045

Cholesterol

powder, BioReagent, suitable for cell culture, ≥99%

T9900

Methyl tricosanoate

≥99.0% (GC)

C4951

Cholesterol-Water Soluble

powder, BioReagent, suitable for cell culture

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Related Product Resources

Protocol: Liposome Preparation - Avanti^® Polar Lipids
Protocol: Preparation of Cationic Liposomes & Transfection of Cells - Avanti^® Polar Lipids
Protocol: Procedure for Preparation of Cationic Lipid/Oligomer Complex - Avanti^® Polar Lipids
Technical Article: Determination of Phospholipid Oxidation by UV/VIS Spectroscopy - Avanti^® Polar Lipids

Publication: Biofiles - Lipid Metabolism
Brochure: Metabolomics

Related Product Categories

Lipids for Therapeutics and Research

We offer high-quality lipids, including fatty acids, glycerides, sphingolipids and bioactive lipids, for all your lipid analysis needs, from isolation and separation to identification and quantification.

HPLC Columns

Our wide selection of HPLC columns for small and large molecule analysis allows you to enhance the separation process in terms of retention, resolution, selectivity, and analysis time, all while reducing the time for method development.

Lipid Standards

Purchase our lipids and fatty acids standards suitable for your broad range of industrial applications specifically for food matrix testing, microbiology testing, analysis of functional foods or nutraceutical formulations, clinical and diagnostic testing, and biomarker discovery, both prognostic and diagnostic.

Natural Products

Our portfolio of natural products features isolated and purified phytochemical compounds from botanical sources to advance your research endeavors.

Metabolite Libraries

We provide small molecule metabolite libraries and kits with a comprehensive range of primary metabolite compounds covering key metabolic pathways for your metabolomics research.

Stable Isotopes

ISOTEC® Stable Isotopes are stable isotope compounds, ranging from gases to complex molecules, that are useful for tracer studies in proteomics and metabolomics, agents for MRI / MRS, and in a wide range of other biomedical applications.

Avanti® Polar Lipids

We provide Avanti^® Polar Lipids high-purity lipids, adjuvants, and equipment for lipidomics research solutions for complex therapeutic drugs and next generation mRNA vaccines.

Supplements for Cell Culture

Cell culture supplements enable the customization of media with defined characteristics to support specific applications and serum-free culture needs. Our culture-grade supplements include ITS formulations, amino acids, vitamins, antibiotics, and reagents qualified for hybridoma and insect cell culture.

Related Applications

Cell & Developmental Biology Research

Rooted in physiology and biochemistry, cell and development biology features an interdisciplinary approach to understand intracellular and extracellular dynamics.

Metabolomics Research

Metabolomics research is the study of the metabolome, or complete set of metabolites, in biological systems by identifying metabolomic pathways for pharmaceutical and diagnostic, genomics, nutritional, and environmental applications.

Mass Spectrometry

Mass spectrometry (MS) is an analytical tool used to identify compounds, determine chemical structure, and assess isotopic abundance. In MS, samples are ionized, and the resulting ions are identified based on their mass-to-charge (m/z) ratios.

Cancer Research

Cancer research strives to not only identify the cause, but also methods for detection, treatment, and prevention. Learn more about our contributions to cancer research in academic and industrial settings.

Cell Culture Troubleshooting

Expert tips for correcting common problems with cell culture including bacterial and fungal contamination, debris in culture media, cell detachment or clumping, slow growth, and low viability.

Related Services

Bulk and Custom Services

We offer an extensive, reliable supply of production materials in bench to bulk volumes. Our custom services include quality control, testing, documentation services, chemical packaging, contract manufacturing according to your specifications.

Highlights

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Reprogramming the Immune System
Watch how these researchers use high-purity Avanti^® lipids and the Avanti^® mini-extruder to prepare liposome nanoparticles for cancer research.