Buchwald Catalysts & Ligands

As a chemist, you would like to focus on the application of the catalyst and the new chemistry that it will lead to. We want to focus on providing you an unparalleled Buchwald portfolio for your breakthrough ideas. Through our partnership with Stephen Buchwald and his research group at MIT, we are pleased to offer a series of highly active and versatile palladium precatalysts and biarylphosphine ligands used in cross-coupling reactions for the formation of C-C, C-N, C-O, C-F, C-CF, and C-S bonds. The ligands are electron-rich and highly tunable to provide catalyst systems with a diverse scope, high stability, and reactivity.

The corresponding Buchwald precatalysts are air-, moisture-, and thermally-stable and display good solubility in common organic solvents. The employment of these precatalysts in cross-coupling reactions typically allows the researcher to use lower catalyst loadings, and results in shorter reaction times. Additionally, their use ensures the efficient formation of the active catalytic species, generally without reducing agents, and allows one to accurately control the ligand:palladium ratio. The unique features of the precatalysts have led to the discovery of new methods that would not otherwise be feasible using traditional Pd sources.