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Showing 1-30 of 1103 results for "06-570" within Papers
Karine Tréguer et al.
PloS one, 8(1), e54550-e54550 (2013-01-24)
ZFP36 constitutes a small family of RNA binding proteins (formerly known as the TIS11 family) that target mRNA and promote their degradation. In mammals, ZFP36 proteins are encoded by four genes and, although they show similar activities in a cellular
F David Carmona et al.
BMC biology, 6, 44-44 (2008-10-23)
Fossorial mammals face natural selection pressures that differ from those acting on surface dwelling animals, and these may lead to reduced visual system development. We have studied eye development in a species of true mole, the Iberian mole Talpa occidentalis
Intermediate neuronal progenitors (basal progenitors) produce pyramidal-projection neurons for all layers of cerebral cortex.
Kowalczyk, T; Pontious, A; Englund, C; Daza, RA; Bedogni, F; Hodge, R; Attardo, A; Bell et al.
Cerebral Cortex (1991)
An unusual DNA binding compound, S23906, induces mitotic catastrophe in cultured human cells.
Cahuzac N, Studeny A, Marshall K, Versteege I, Wetenhall K, Pfeiffer B, Leonce S et al.
Cancer letters null
José J Rodríguez et al.
PloS one, 3(8), e2935-e2935 (2008-08-14)
It has become generally accepted that new neurones are added and integrated mainly in two areas of the mammalian CNS, the subventricular zone and the subgranular zone (SGZ) of the dentate gyrus (DG) of the hippocampus, which is of central
Kristi Bray et al.
Small GTPases, 2(5), 247-258 (2012-02-01)
The Rho GTPase Cdc42 is overexpressed and hyperactivated in breast cancer, and several studies have described mechanisms by which it may promote tumor formation and progression. However, little is known about the role of Cdc42 during normal mammary epithelial cell
Patricia Rivera et al.
Frontiers in cellular neuroscience, 9, 379-379 (2015-10-21)
Chronic alcohol exposure reduces endocannabinoid activity and disrupts adult neurogenesis in rodents, which results in structural and functional alterations. Cannabinoid receptor agonists promote adult neural progenitor cell (NPC) proliferation. We evaluated the protective effects of the selective CB1 receptor agonist
The prognostic value of mitotic activity index (MAI), phosphohistone H3 (PPH3), cyclin B1, cyclin A, and Ki67, alone and in combinations, in node-negative premenopausal breast cancer.
Klintman, M; Strand, C; Ahlin, C; Beglerbegovic, S; Fjallskog, ML; Grabau, D; Gudlaugsson et al.
Testing null
Vladimir Ustiyan et al.
Developmental biology, 336(2), 266-279 (2009-10-20)
The forkhead box m1 (Foxm1 or Foxm1b) transcription factor (previously called HFH-11B, Trident, Win, or MPP2) is expressed in a variety of tissues during embryogenesis, including vascular, airway, and intestinal smooth muscle cells (SMCs). Although global deletion of Foxm1 in
Seung Tae Baek et al.
Development (Cambridge, England), 139(11), 2040-2049 (2012-04-27)
The epicardium is the primary source of coronary vascular smooth muscle cells (cVSMCs) and fibroblasts that reside in the compact myocardium. To form these epicardial-derived cells (EPDCs), the epicardium undergoes the process of epithelial to mesenchymal transition (EMT). Although several
Kelly M Bush et al.
Epigenetics & chromatin, 6(1), 7-7 (2013-04-11)
The histone variant H3.3 plays key roles in regulating chromatin states and transcription. However, the role of endogenous H3.3 in mammalian cells and during development has been less thoroughly investigated. To address this gap, we report the production and phenotypic
Hideyuki Komori et al.
Development (Cambridge, England), 141(1), 51-62 (2013-11-22)
During asymmetric stem cell division, both the daughter stem cell and the presumptive intermediate progenitor cell inherit cytoplasm from their parental stem cell. Thus, proper specification of intermediate progenitor cell identity requires an efficient mechanism to rapidly extinguish the activity
Atsushi Kitajima et al.
Developmental biology, 347(1), 9-23 (2010-07-06)
Asymmetric cell division generates two daughter cells of differential gene expression and/or cell shape. Drosophila neuroblasts undergo typical asymmetric divisions with regard to both features; this is achieved by asymmetric segregation of cell fate determinants (such as Prospero) and also
Disruption of G-protein ?5 subtype causes embryonic lethality in mice.
Moon, AM; Stauffer, AM; Schwindinger, WF; Sheridan, K; Firment, A; Robishaw, JD
Testing null
Phosphorylation of histone H4 Ser1 regulates sporulation in yeast and is conserved in fly and mouse spermatogenesis.
Krishnamoorthy, T; Chen, X; Govin, J; Cheung, WL; Dorsey, J; Schindler, K; Winter et al.
Genes & Development null
Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells.
Yamada, Mitsutoshi, et al.
Nature (2014)
Increased apoptosis and DNA double-strand breaks in the embryonic mouse brain in response to very low-dose X-rays but not 50 Hz magnetic fields.
Saha, S; Woodbine, L; Haines, J; Coster, M; Ricket, N; Barazzuol, L; Ainsbury et al.
Journal of the Royal Society, Interface / the Royal Society null
Sushil Kumar et al.
Translational oncology, 6(4), 493-503 (2013-08-03)
Metronomic chemotherapy, combined with targeted antiangiogenic drugs, has demonstrated significant anticancer efficacy in various studies. Though, tumors do acquire resistance. Here, we have investigated the effect of prolonged therapy with oral metronomic topotecan and pazopanib on tumor behavior in a
Samantha England et al.
Development (Cambridge, England), 138(23), 5121-5134 (2011-11-10)
In mouse, Hedgehog (Hh) signalling is required for most ventral spinal neurons to form. Here, we analyse the spinal cord phenotype of zebrafish maternal-zygotic smoothened (MZsmo) mutants that completely lack Hh signalling. We find that most V3 domain cells and
A conserved Pbx-Wnt-p63-Irf6 regulatory module controls face morphogenesis by promoting epithelial apoptosis.
Ferretti, E; Li, B; Zewdu, R; Wells, V; Hebert, JM; Karner, C; Anderson, MJ; Williams et al.
Developmental Cell null
Heather L Franco et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 26(3), 1218-1227 (2011-12-14)
The ovarian steroid progesterone, acting through the progesterone receptor (PR), coordinates endometrial epithelial-stromal cell communication, which is critical for its development and function. PR expression in these cellular compartments is under tight temporal and endocrine control. Although ex vivo studies
Dissecting early regulatory relationships in the lamprey neural crest gene network.
Nikitina, N; Sauka-Spengler, T; Bronner-Fraser, M
Proceedings of the National Academy of Sciences of the USA null
Modification of the DNA damage response by therapeutic CDK4/6 inhibition.
Dean, JL; McClendon, AK; Knudsen, ES
The Journal of Biological Chemistry null
An equatorial contractile mechanism drives cell elongation but not cell division.
Sehring, IM; Dong, B; Denker, E; Bhattachan, P; Deng, W; Mathiesen, BT; Jiang, D
PLoS Biology null
Weijun Liu et al.
Carcinogenesis, 29(2), 263-272 (2008-01-05)
As a critical ubiquitin ligase, the anaphase-promoting complex/cyclosome (APC/C) governs cell cycle progression, signaling modulation and the pathogenesis of some human diseases. Recent studies implicate APC in maintaining genomic integrity, but the mechanism by which it plays such a role
Xi Huang et al.
Genes & development, 26(16), 1780-1796 (2012-08-03)
Medulloblastoma (MB) is the most common pediatric CNS malignancy. We identify EAG2 as an overexpressed potassium channel in MBs across different molecular and histological subgroups. EAG2 knockdown not only impairs MB cell growth in vitro, but also reduces tumor burden
YuKyung Lee et al.
Cell cycle (Georgetown, Tex.), 12(8), 1303-1315 (2013-03-29)
Src family kinases (SFKs) regulate the completion of cytokinesis through signal transduction pathways that lead to the Rab11-dependent phosphorylation of ERK and its localization to the midbody of cytokinetic cells. We find that UNC119a, a known activator of SFKs, plays
Extensive Pancreas Regeneration Following Acinar-Specific Disruption of Xbp1 in Mice.
Hess DA, Humphrey SE, Ishibashi J, Damsz B, Lee AH, Glimcher LH, Konieczny SF
Gastroenterology null
Phosphorylation of myosin II-interacting guanine nucleotide exchange factor (MyoGEF) at threonine 544 by aurora B kinase promotes the binding of polo-like kinase 1 to MyoGEF.
Wu, D; Asiedu, M; Matsumura, F; Wei, Q
The Journal of Biological Chemistry null
Aurora B is required for mitotic chromatin-induced phosphorylation of Op18/Stathmin.
Gadea, BB; Ruderman, JV
Proceedings of the National Academy of Sciences of the USA null
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