375810

Applied Filters:

Keyword:'375810'

Showing 1-30 of 93 results for "375810" within Papers

Development of a hypersensitive periodate-cleavable amino acid that is methionine- and disulfide-compatible and its application in MHC exchange reagents for T cell characterisation.

Alessia Amore et al.

Chembiochem : a European journal of chemical biology, 14(1), 123-131 (2013-01-03)

Incorporation of cleavable linkers into peptides and proteins is of particular value in the study of biological processes. Here we describe the synthesis of a cleavable linker that is hypersensitive to oxidative cleavage as the result of the periodate reactivity

Up regulation of liver-enriched transcription factors HNF4a and HNF6 and liver-specific microRNA (miR-122) by inhibition of let-7b in mesenchymal stem cells.

Effat Alizadeh et al.

Chemical biology & drug design, 85(3), 268-279 (2014-07-26)

MicroRNAs are small non-coding RNAs that regulate key processes of the stem cells. Although, microRNAs have emerged as powerful regulators of differentiation, few studies have been focused on the post-transcriptional regulation of hepatic differentiation in mesenchymal stem cells (MSCs) by

In vivo experiments reveal the good, the bad and the ugly faces of sFlt-1 in pregnancy.

Gabor Szalai et al.

PloS one, 9(11), e110867-e110867 (2014-11-14)

Soluble fms-like tyrosine kinase (sFlt)-1-e15a, a primate-specific sFlt-1-isoform most abundant in the human placenta in preeclampsia, can induce preeclampsia in mice. This study compared the effects of full-length human (h)sFlt-1-e15a with those of truncated mouse (m)sFlt-1(1-3) used in previous preeclampsia

IL-33 promotes the induction of immunoglobulin production after inhalation of house dust mite extract in mice.

D Canbaz et al.

Allergy, 70(5), 522-532 (2015-02-14)

The initial immune response to house dust mite (HDM) is orchestrated by an interplay between epithelial cells (ECs) and dendritic cells (DCs). Innate cytokines released by HDM-exposed ECs activate airway DCs and effector inflammatory cells, which together induce a HDM-specific

Expression of the lymphatic marker podoplanin (D2-40) in human fetal eyes.

Martina C Herwig et al.

Experimental eye research, 127, 243-251 (2014-08-20)

During human ocular development, expression of proteins varies in different maturation stages. This study aims to characterize structures in human fetal eyes stained by the lymphatic marker podoplanin (D2-40) with emphasis on the stage of maturation and the presence of

Chemical modification of carbohydrates in tissue sections may unmask mucin antigens.

S Kirkeby

Biotechnic & histochemistry : official publication of the Biological Stain Commission, 88(1), 19-26 (2012-09-25)

Expression of mucins in cells and tissues is of great diagnostic and prognostic importance, and immunohistochemistry frequently is used to detect them. Reports concerning mucin localization in sections sometimes are conflicting, however, partly because immunogenic regions of the mucin molecule

A mild and efficient oxidation of alcohols to aldehydes and ketones with periodic acid catalyzed by chromium (III) acetylacetonate.

Xu L and Trudell ML.

Tetrahedron Letters, 44(12), 2553-2555 (2003)

The development of mixed cryoglobulinemia in Capillaria hepatica-infected mice is associated with the capillaria antigen-induced selective proliferation of splenic B-1a cells in response to interleukin-5 stimulation.

Naoyuki Aihara et al.

The American journal of pathology, 185(1), 172-184 (2014-12-03)

Chronic infection by pathogens such as hepatitis C virus induces monoclonal or oligoclonal proliferation of B cells, which produce IgM rheumatoid factor, leading to the development of mixed cryoglobulinemia (MC). Antigen-driven lymphoproliferation is essential to the onset of MC; however

Promotion of mesenchymal-to-epithelial transition by Rac1 inhibition with small molecules accelerates hepatic differentiation of mesenchymal stromal cells.

Nan-Yuan Teng et al.

Tissue engineering. Part A, 21(7-8), 1444-1454 (2015-01-28)

In vitro differentiation of stem cells into specific cell lineages provides a stable cell supply for cell therapy and tissue engineering. Therefore, understanding the mechanisms underlying such differentiation processes is critical for generating committed lineage-specific cell progenies effectively. We previously

The CRE1 cytokinin pathway is differentially recruited depending on Medicago truncatula root environments and negatively regulates resistance to a pathogen.

Carole Laffont et al.

PloS one, 10(1), e0116819-e0116819 (2015-01-07)

Cytokinins are phytohormones that regulate many developmental and environmental responses. The Medicago truncatula cytokinin receptor MtCRE1 (Cytokinin Response 1) is required for the nitrogen-fixing symbiosis with rhizobia. As several cytokinin signaling genes are modulated in roots depending on different biotic

Sialic acid capture-and-release and LC-MS(n) analysis of glycopeptides.

Jonas Nilsson et al.

Methods in molecular biology (Clifton, N.J.), 951, 79-100 (2013-01-09)

Extracellular glycoproteins frequently carry terminal sialic acids on their N-linked and/or O-linked glycan structures. In this chapter a sialic acid specific capture-and-release protocol for the enrichment of N- and O-glycopeptides originating from glycoproteins in complex biological samples is described. The

Androgen supplementation in rats increases the inflammatory response and prolongs urethral healing.

Matthias D Hofer et al.

Urology, 85(3), 691-697 (2015-03-04)

To describe the effects of androgens on urethral wound healing, we compared the urethral healing process in castrated Sprague-Dawley rats with and without testosterone supplementation. Of 30 castrated male Sprague-Dawley rats, 15 received testosterone cypionate (3 mg/kg; T+ rats). All

Impaired L-arginine uptake but not arginase contributes to endothelial dysfunction in rats with chronic kidney disease.

Christopher R Martens et al.

Journal of cardiovascular pharmacology, 63(1), 40-48 (2013-10-03)

Reduced nitric oxide bioavailability contributes to increased cardiovascular disease risk in patients with chronic kidney disease (CKD). Arginase has been implicated as a potential therapeutic target to treat vascular dysfunction by improving substrate availability for endothelial nitric oxide synthase. The

Functional interaction between angiotensin II receptor type 1 and chemokine (C-C motif) receptor 2 with implications for chronic kidney disease.

Mohammed Akli Ayoub et al.

PloS one, 10(3), e0119803-e0119803 (2015-03-26)

Understanding functional interactions between G protein-coupled receptors is of great physiological and pathophysiological importance. Heteromerization provides one important potential mechanism for such interaction between different signalling pathways via macromolecular complex formation. Previous studies suggested a functional interplay between angiotensin II

Histological and histochemical uses of periodic acid.

J F A McMANUS

Stain technology, 23(3), 99-108 (1948-07-01)

Lactobacillus casei and bifidobacterium lactis supplementation reduces tissue damage of intestinal mucosa and liver after 2,4,6-trinitrobenzenesulfonic acid treatment in mice.

M Bellavia et al.

Journal of biological regulators and homeostatic agents, 28(2), 251-261 (2014-07-09)

Probiotics (PB) are living microorganisms that act as a commensal population in normal intestines and confer numerous beneficial effects on the host. The introduction of probiotics in the treatment of inflammatory bowel disease (IBD) prolongs remission. The aim of this

A Convenient and Efficient Method to Enrich and Maintain Highly Proliferative Human Fetal Liver Stem Cells.

Xuan Guo et al.

Rejuvenation research, 18(3), 211-224 (2015-01-06)

Pluripotent human hepatic stem cells have broad research and clinical applications, which are, however, restricted by both limited resources and technical difficulties with respect to isolation of stem cells from the adult or fetal liver. In this study, we developed

Expression of a novel stress-inducible protein, sestrin 2, in rat glomerular parietal epithelial cells.

Hiroko Hamatani et al.

American journal of physiology. Renal physiology, 307(6), F708-F717 (2014-07-25)

Sestrin 2, initially identified as a p53 target protein, accumulates in cells exposed to stress and inhibits mammalian target of rapamycin (mTOR) signaling. In normal rat kidneys, sestrin 2 was selectively expressed in parietal epithelial cells (PECs), identified by the

Periodic Acid Oxidation.

Jackson EL.

Organic Reactions, 341-375 null

Structure analysis and antimutagenic activity of a novel salt-soluble polysaccharide from Auricularia polytricha.

Jie Zhou et al.

Journal of the science of food and agriculture, 93(13), 3225-3230 (2013-04-05)

Auricularia polytricha is known to be a highly nutritious foodstuff. We report here the purification, structure characterization and antimutagenic activity in vivo of a 0.9% NaCl solution-soluble polysaccharide (SSP) from the mycelia of A. polytricha. Analysis by high-performance liquid chromatography

Carbohydrate histochemistry studied by acetylation techniques: I. Periodic acid methods.

McManus JFA and Cason JE.

The Journal of Experimental Medicine, 91(6), 651-651 (1950)

Glycoproteomics enabled by tagging sialic acid- or galactose-terminated glycans.

T N C Ramya et al.

Glycobiology, 23(2), 211-221 (2012-10-17)

In this paper, we present two complementary strategies for enrichment of glycoproteins on living cells that combine the desirable attributes of "robust enrichment" afforded by covalent-labeling techniques and "specificity for glycoproteins" typically provided by lectin or antibody affinity reagents. Our

Acute and long-term biological effects of mechanically and chemically dispersed oil on lumpsucker (Cyclopterus lumpus).

Marianne Frantzen et al.

Marine environmental research, 105, 8-19 (2015-02-01)

Concentration dependent differences in acute and long-term effects of a 48 h exposure to mechanically or chemically dispersed crude oil were assessed on juvenile lumpsucker (Cyclopterus lumpus). Acute or post-exposure mortality was only observed at oil concentrations representing higher concentrations

A periodate-cleavable linker for functional proteomics under slightly acidic conditions: application for the analysis of intracellular aspartic proteases.

Andreas Maurer et al.

Journal of proteome research, 12(1), 199-207 (2012-11-28)

Specific elution of captured proteins greatly improves the quality of proteomic data obtained from pull-downs by avoiding signals from nonspecific proteins, thus allowing more sensitive identification of target proteins. This is important in activity-based proteomics or drug target identification. However

An alternative role of C1q in bacterial infections: facilitating Streptococcus pneumoniae adherence and invasion of host cells.

Vaibhav Agarwal et al.

Journal of immunology (Baltimore, Md. : 1950), 191(8), 4235-4245 (2013-09-17)

Streptococcus pneumoniae (pneumococcus) is a major human pathogen, which evolved numerous successful strategies to colonize the host. In this study, we report a novel mechanism of pneumococcal-host interaction, whereby pneumococci use a host complement protein C1q, primarily involved in the

A novel nonhuman primate model of cigarette smoke-induced airway disease.

Francesca Polverino et al.

The American journal of pathology, 185(3), 741-755 (2014-12-30)

Small animal models of chronic obstructive pulmonary disease (COPD) have several limitations for identifying new therapeutic targets and biomarkers for human COPD. These include a pulmonary anatomy that differs from humans, the limited airway pathologies and lymphoid aggregates that develop

Bioengineered human tumor within a bone niche.

Aranzazu Villasante et al.

Biomaterials, 35(22), 5785-5794 (2014-04-22)

Monolayer cultures of tumor cells and animal studies have tremendously advanced our understanding of cancer biology. However, we often lack animal models for human tumors, and cultured lines of human cells quickly lose their cancer signatures. In recent years, simple

Honey glycoproteins containing antimicrobial peptides, Jelleins of the Major Royal Jelly Protein 1, are responsible for the cell wall lytic and bactericidal activities of honey.

Katrina Brudzynski et al.

PloS one, 10(4), e0120238-e0120238 (2015-04-02)

We have recently identified the bacterial cell wall as the cellular target for honey antibacterial compounds; however, the chemical nature of these compounds remained to be elucidated. Using Concavalin A-affinity chromatography, we found that isolated glycoprotein fractions (glps), but not

Screening of polysaccharides for preparation of α-amylase conjugate to enhance stability and storage life.

Swati B Jadhav et al.

Carbohydrate polymers, 92(2), 1724-1729 (2013-02-13)

Nine polysaccharides differing in structure and chemical nature were screened for their ability to conjugate with α-amylase by covalent binding for enhancing the thermal and pH stability of α-amylase. Among these polysaccharides, agar, dextran, pectin and xanthan showed better results

Development of a compact chemiluminescence system coupled with capillary electrophoresis for carbohydrate analysis.

Jinkun Zhu et al.

Talanta, 93, 428-432 (2012-04-10)

As a kinetic process, chemiluminescence (CL) met great challenges while it was used in the detection methods coupled with capillary electrophoresis (CE). In this investigation, a newly recorded ultra-fast CL reaction of luminol-KIO(4)-K(3)Fe(CN)(6) was observed to be completed in 0.65

Page 1 of 4