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Showing 1-30 of 142 results for "504955-40" within Papers
Mayca Onega et al.
Future medicinal chemistry, 1(5), 865-873 (2009-08-01)
There is an increasing interest in the preparation of (18)F-labeled radiopharmaceuticals with potential applications in PET for medicinal imaging. Appropriate synthetic methods require a quick and efficient route in which to incorporate the (18)F into a ligand, due to the
Agata Zygler et al.
Talanta, 82(5), 1742-1748 (2010-09-30)
The objective of this paper is to provide information about application of solid-phase extraction (SPE) for isolation of nine high-intensity sweeteners (acesulfame-K, alitame, aspartame, cyclamate, dulcin, neotame, saccharin, sucralose and neohesperidin dihydrochalcone) from aqueous solutions. The influence of several types
Michael T Baynham et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 772(1), 155-161 (2002-05-23)
The alpha3beta4 subtype of the neuronal nicotinic acetylcholine receptor (nAChR) subtype was immobilized on a liquid chromatographic support and the resulting column used for the rapid and direct on-line screening for nAChR ligands. A multidimensional chromatographic system was developed consisting
G F van Rooyen et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 768(2), 223-229 (2002-03-14)
A sensitive method for the determination of clarithromycin in plasma is described, using high-performance liquid chromatographic separation with tandem mass spectrometric detection. Samples were prepared using liquid-liquid extraction and separated on a Supelco Discovery C18 column with a mobile phase
Ramisetti Nageswara Rao et al.
Journal of separation science, 32(9), 1312-1322 (2009-04-29)
Modafinil, adrafinil and their related substances were synthesized and analyzed by RP-LC with ESI-MS/MS. The ionization mode, polarity, cone voltage, and chromatographic conditions were evaluated. The optimum LC-MS conditions to obtain fragment ions indispensable for identification of the structures were
Wen-zhi Yang et al.
Analytica chimica acta, 739, 56-66 (2012-07-24)
To discover new natural compounds from herbal medicines tends to be more and more difficult. In this paper, a strategy integrating orthogonal column chromatography and liquid chromatography/mass spectrometry (LC/MS) analysis was proposed, and was applied for rapid discovery of new
H Z Bu et al.
Rapid communications in mass spectrometry : RCM, 15(10), 741-748 (2001-05-10)
The inhibition potential of drugs towards five major human hepatic cytochrome P450 (CYP) isozymes (CYP2A6, 3A4, 2C9, 2D6, and 2E1) was investigated via cassette dosing of the five probe substrates (coumarin, midazolam, tolbutamide, dextromethorphan, and chlorzoxazone) in human liver microsomes
Macarena Ramos et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 789(2), 373-381 (2003-05-14)
A simple and sensitive high-performance liquid chromatographic (HPLC) method has been developed for the determination of five different quinolones: enrofloxacin, ciprofloxacin, sarafloxacin, oxolinic acid and flumequine in pork and salmon muscle. The method includes one extraction and clean-up step for
A Srinivas et al.
International journal of systematic and evolutionary microbiology, 62(Pt 10), 2528-2532 (2011-12-20)
An oval to rod-shaped, Gram-stain-negative, phototrophic bacterium, strain JA738(T), was isolated from a sediment sample collected from a pink pond. Strain JA738(T) was non-motile and had vesicular-type intracellular photosynthetic membranes. Bacteriochlorophyll a and carotenoids of the spheroidene series were present
Lucie Nováková et al.
Analytical and bioanalytical chemistry, 379(5-6), 781-787 (2004-03-05)
This paper deals with the development of a novel method for simultaneous determination of estradiol, its degradation product estrone, and two preservatives, methylparaben and propylparaben, in the topical preparation Estradiol HBF. After optimization of the analytical conditions the method was
Wenyan Wang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 863(1), 163-166 (2008-02-05)
A quick, precise and reliable HPLC method has been developed to determine tripterin in rat plasma. After liquid-liquid extraction, the analytes was analyzed on a Discovery ODS C(18) column (5microm, 4.6mmx250mm) with an isocratic elution consisting of methanol-water-phosphoric acid (87:13:0.2
Sheelendra Pratap Singh et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 876(1), 1-7 (2008-11-14)
A highly sensitive and specific HPLC-ESI-MS/MS method has been developed and validated for the estimation of centchroman with 100 microL rat plasma using tamoxifen as an internal standard (IS). The assay procedure involved a single-step, liquid-liquid extraction of centchroman and
Roman Kand'ár et al.
Journal of pharmaceutical and biomedical analysis, 43(4), 1382-1387 (2006-12-22)
A HPLC method for determination of both reduced (GSH) and oxidized (GSSG) glutathione in plasma, whole blood and rat hepatocytes has been developed and evaluated. Reduced glutathione reacts with orthophthaldehyde (OPA) to form a stable, highly fluorescent tricyclic derivate at
Hui Chen et al.
Talanta, 107, 88-94 (2013-04-20)
A method to study Abl1 tyrosine kinase inhibitors (TKIs) by liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS) was developed and validated. Chromatographic separation was achieved on a Symmetry(®) C-18 column using a gradient. The detection was performed by selected ion monitoring (SIM)
R Nageswara Rao et al.
Journal of pharmaceutical and biomedical analysis, 46(1), 94-103 (2007-10-24)
A reversed-phase high performance liquid chromatographic (RP-HPLC) method for evaluation of purity of tamsulosin in bulk drugs and pharmaceuticals was developed. The separation was accomplished on an Inertsil C(18) column using 10 mM ammonium acetate: acetonitrile as a mobile phase
Antal Péter et al.
Journal of chromatography. A, 1031(1-2), 171-178 (2004-04-03)
Direct and indirect reversed-phase (RP) high-performance liquid chromatographic methods were developed for the separation of enantiomers of 18 unnatural beta-amino acids, including several beta-3-homo amino acids. The direct separations of the underivatized analytes were performed on chiral stationary phases (CSPs)
Dan Song et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 33(17), 2133-2135 (2008-12-11)
To determine lobetyolin in the root of Codonopsis tangshen from the various cultivation areas. A Supelco Discovery C18 Column (4.6 mm x 250 mm, 5 microm) was used with acetonitrile-0.5% acetic acid in water (20:80) as the mobile phase and
Robert W Hepler et al.
Protein science : a publication of the Protein Society, 27(11), 1923-1941 (2018-08-26)
Chlamydial major outer membrane protein (MOMP) is the major protein constituent of the bacterial pathogen Chlamydia trachomatis. Chlamydia trachomatis Serovars D-K are the leading cause of genital tract infections which can lead to infertility or ectopic pregnancies. A vaccine against
E Dijkman et al.
Journal of chromatography. A, 926(1), 113-125 (2001-09-14)
This study investigated the effects of matrix interferences on the analytical performance of a triple quadrupole mass spectrometric (MS-MS) detector coupled to various reversed-phase liquid chromatographic (LC) modes for the on-line determination of various types of acidic herbicides in water
Yulia Y Tyurina et al.
Free radical biology & medicine, 44(3), 299-314 (2008-01-25)
Although gamma-irradiation-induced tissue injury has been associated with lipid peroxidation, the individual phospholipid molecular targets have not been identified. We employed oxidative lipidomics to qualitatively and quantitatively characterize phospholipid peroxidation in a radiosensitive tissue, the small intestine, of mice exposed
P Shalem Raj et al.
International journal of systematic and evolutionary microbiology, 62(Pt 5), 1069-1074 (2011-06-28)
Two strains (JA492(T) and JA590) of spiral-shaped, anaerobic, Gram-stain-negative, motile, purple non-sulfur bacteria were isolated from aquatic sediments from a bird sanctuary and a stream, respectively, and were characterized by a polyphasic taxonomic approach. Bacteriochlorophyll a and carotenoids (rhodopin, lycopene
Andrew N Hobbs et al.
Drug discovery today, 18(3-4), 148-154 (2012-09-25)
Practical purifications of hydrophilic fragments and lead/drug-like molecules are reviewed, focussing particularly on the rational use of C-18 reverse phase flash chromatography by exploiting the relationship between retention time and distribution coefficients. Logical process changes have been implemented to suit
Ghada M Hadad et al.
Talanta, 79(5), 1360-1367 (2009-07-29)
A stability-indicating reversed-phase high-performance liquid chromatography (RP-HPLC) method has been developed which can separate and accurately quantitate paracetamol, dantrolene, cetirizine and pseudoephedrine. The method was successfully validated for the purpose of conducting stability studies of the four analytes in quality
Yuan-Qing Xia et al.
Rapid communications in mass spectrometry : RCM, 20(12), 1831-1837 (2006-05-18)
A major challenge in selecting an appropriate stationary phase for diastereomeric separation is that it is difficult to predict which of the commercially available stationary phases could achieve the required liquid chromatographic (LC) separation. This work describes the selection and
R D Yeole et al.
Journal of chromatography. A, 1108(1), 38-42 (2006-01-24)
A sensitive, simple, specific, precise, accurate and rugged method for the assay and determination of enantiomeric purity of S-(-)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid L-arginine salt tetrahydrate (WCK 771) in bulk drug has been developed. The method is RP-HPLC using endcapped C-18 stationary phase
György Székely et al.
Drug testing and analysis, 6(9), 898-908 (2013-11-19)
This paper discusses a design of experiments (DoE) assisted optimization and robustness testing of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method development for the trace analysis of the potentially genotoxic 1,3-diisopropylurea (IPU) impurity in mometasone furoate glucocorticosteroid. Compared to the
L Havlíková et al.
Journal of pharmaceutical and biomedical analysis, 41(2), 671-675 (2006-02-14)
A RP-HPLC method for simultaneous determination of calcium pantothenate and two preservatives methylparaben and propylparaben present in topical cream was developed. Different analytical columns with various stationary phases were tested. During method development, Supelco Discovery C18 column (125 mmx4.0 mm
Jiaxin Pi et al.
Pakistan journal of pharmaceutical sciences, 28(1), 213-220 (2015-01-03)
In targeting delivery system research on salvianolic acid B, it's vital but hard to evaluate the tissue distribution for its low concentrations in tissues. So the simple, rapid, selective and sensitive UPLC-MS/MS method was provided hereby to determine the concentration
A E Leonard et al.
The Biochemical journal, 350 Pt 3, 765-770 (2000-09-06)
The Saccharomyces cerevisiae protein ELO2p is involved in the elongation of saturated and monounsaturated fatty acids. Among several sequences with limited identity with the S. cerevisiae ELO2 gene, a consensus cDNA sequence was identified from the LifeSeq(R) database of Incyte
R Nageswara Rao et al.
Talanta, 73(3), 407-414 (2007-09-30)
A reversed-phase high-performance liquid chromatographic (RP-HPLC) method for determination and evaluation of purity of modafinil in bulk drugs using Kromasil C(18) column with acetonitrile: 0.02M ammonium acetate as a mobile phase in gradient elution mode at 30 degrees C and
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