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Showing 1-30 of 124 results for "50553" within Papers
Kaoru Suzuki et al.
Biological & pharmaceutical bulletin, 38(4), 611-617 (2015-04-04)
Metal responsive element (MRE)-binding transcription factor-1 (MTF-1) is a zinc finger (ZF) transcription factor that plays a key role in heavy metal homeostasis by regulating relevant genes in response to metals. MTF-1 is known to be activated by heavy metals
Gerjon Hannink et al.
Journal of materials science. Materials in medicine, 24(2), 325-332 (2012-11-09)
Bone morphogenetic proteins (BMPs) are the most potent osteoinductive growth factors. However, a delivery system is essential to take advantage of the osteoinductive effect of BMPs. The purpose of this study was to develop a sustained delivery system for recombinant
Harshi Weerakoon et al.
PloS one, 10(4), e0121537-e0121537 (2015-04-09)
Records on gallstones and associated ailments in Sri Lankan community are scarce, despite frequent detection of gallstone disease. Identification of the chemical composition of gallstones in the local setting is important in defining aetiopathogenic factors which in turn are useful
Svetlana Trifunović et al.
Acta histochemica, 116(5), 717-722 (2014-02-04)
Numerous studies have established a link between estrogen levels and activity of the hypothalamic pituitary adrenal (HPA) system. Considering the "weak estrogenic" effect of soy isoflavones, this study was designed to evaluate the influence of soy extract treatment on some
Jose-Andres C Portillo et al.
Investigative ophthalmology & visual science, 55(12), 8590-8597 (2014-12-06)
The cell surface receptor CD40 is required for the development of retinopathies induced by diabetes and ischemia/reperfusion. The purpose of this study was to identify signaling pathways by which CD40 triggers proinflammatory responses in retinal cells, since this may lead
β-Tricalcium phosphate implant to repair empty nose syndrome: preliminary results.
Pierre-Louis Bastier et al.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 148(3), 519-522 (2013-01-10)
Isabel Sánchez-Muñoz et al.
Tissue engineering. Part A, 21(1-2), 214-223 (2014-07-11)
In recent years, the reconstruction of human skin by tissue engineering represents a clinical challenge and has offered a therapeutic alternative. Avascular engineered skin equivalents have been available for several years and used to treat wounds due to burns, nonhealing
Crosstalk between VEGF and MTA1 signaling pathways contribute to aggressiveness of breast carcinoma.
Sachin Raj M Nagaraj et al.
Molecular carcinogenesis, 54(5), 333-350 (2013-11-23)
The expression of metastasis associated protein (MTA1) correlates well with tumor metastasis; however its role as a proangiogenic protein and the molecular mechanisms underlying the same are not fully understood. In this study the MTA1 protein was expressed and purified
Delfo D'Alessandro et al.
Biomedical materials (Bristol, England), 9(4), 045007-045007 (2014-07-17)
In this study, we performed a complete histologic analysis of constructs based on large diameter ( >100 μm) poly-L-lactic acid (PLLA) microfibers obtained via dry-wet spinning and rat Mesenchymal Stromal Cells (rMSCs) differentiated towards the osteogenic lineage, using acrylic resin embedding.
Wan-Chen Lin et al.
PloS one, 9(11), e112088-e112088 (2014-11-12)
High-affinity blockers for an ion channel often have complex molecular structures that are synthetically challenging and/or laborious. Here we show that high-affinity blockers for the mouse nicotinic acetylcholine receptor (AChR) can be prepared from a structurally simple material, poly(ethylene glycol)
Hyun-Woo Shin et al.
Gastroenterology, 147(2), 430-442 (2014-05-23)
Immunoglobulin transcription factor 2 (ITF2) was believed to promote neoplastic transformation via activation of β-catenin. However, ITF2 recently was reported to suppress colon carcinogenesis. We investigated the roles of ITF2 in colorectal cancer cell lines and tumor formation and growth
Krzysztof W Luczynski et al.
Journal of biomedical materials research. Part A, 101(1), 138-144 (2012-07-25)
This paper is concerned with reliable and physically sound elasticity determination of rapid-prototyped tissue engineering scaffolds made of poly-L-lactide (PLLA), with and without small portions of tricalcium phosphate (TCP) inclusions. At the level of overall scaffolds, that is, that of
Nikita A Mitkin et al.
Scientific reports, 5, 9330-9330 (2015-03-20)
Elevated expression of chemokine receptors in tumors has been reported in many instances and is related to a number of survival advantages for tumor cells including abnormal activation of prosurvival intracellular pathways. In this work we demonstrated an inverse correlation
Emily B Cohen et al.
PloS one, 9(4), e95593-e95593 (2014-05-03)
Transmembrane proteins constitute a large fraction of cellular proteins, and specific interactions involving membrane-spanning protein segments play an important role in protein oligomerization, folding, and function. We previously isolated an artificial, dimeric, 44-amino acid transmembrane protein that activates the human
Praphasri Rirattanapong et al.
The Southeast Asian journal of tropical medicine and public health, 43(4), 1053-1058 (2012-10-20)
The aim of this in vitro study was to compare the remineralization potential of dental products containing calcium on human enamel softened by soft drinks. Fifty sound human premolar teeth were randomly divided into 5 treatment groups (n=10): artificial saliva
S Demajo et al.
Oncogene, 33(48), 5501-5510 (2013-12-03)
Acute myeloid leukemia (AML) is frequently linked to epigenetic abnormalities and deregulation of gene transcription, which lead to aberrant cell proliferation and accumulation of undifferentiated precursors. ZRF1, a recently characterized epigenetic factor involved in transcriptional regulation, is highly overexpressed in
A Caspase-3 Reporter for Fluorescence Lifetime Imaging of Single-Cell Apoptosis
Buschhaus J, et al.
Cells, 7(6), 57-57 (2018)
B T Amaechi et al.
General dentistry, 60(4), e186-e192 (2012-07-12)
The present study evaluated the ability of a high-fluoride dentifrice containing tricalcium phosphate to remineralize white spot lesions and inhibit lesion formation. Three demineralized enamel blocks and three healthy blocks (cut from a group of 30 molars), were exposed in
S Weninger et al.
Cellular signalling, 26(11), 2573-2582 (2014-08-08)
Phosphodiesterase (PDE) 3 and PDE4, which degrade cyclic adenosine monophosphate (cAMP), are important regulators of 5-hydroxytryptamine (5-HT) 4 receptor signaling in cardiac tissue. Therefore, we investigated whether they interact with the 5-HT4(b) receptor, and whether A-kinase anchoring proteins (AKAPs), scaffolding
James A McCormick et al.
The Journal of clinical investigation, 124(11), 4723-4736 (2014-09-25)
Familial hyperkalemic hypertension (FHHt) is a monogenic disease resulting from mutations in genes encoding WNK kinases, the ubiquitin scaffold protein cullin 3 (CUL3), or the substrate adaptor kelch-like 3 (KLHL3). Disease-associated CUL3 mutations abrogate WNK kinase degradation in cells, but
N S Murni et al.
Materials science & engineering. C, Materials for biological applications, 49, 560-566 (2015-02-18)
The recent proposal of using Zn-based alloys for biodegradable implants was not supported with sufficient toxicity data. This work, for the first time, presents a thorough cytotoxicity evaluation of Zn-3Mg alloy for biodegradable bone implants. Normal human osteoblast cells were
Ronit Shtrichman et al.
Tissue engineering. Part A, 20(19-20), 2756-2767 (2014-09-04)
Extracellular matrix (ECM) has been utilized as a biological scaffold for tissue engineering applications in a variety of body systems, due to its bioactivity and biocompatibility. In the current study we developed a modified protocol for the efficient and reproducible
A H Choi et al.
Journal of dental research, 92(10), 853-859 (2013-07-17)
The purpose of coatings on implants is to achieve some or all of the improvements in biocompatibility, bioactivity, and increased protection from the release of harmful or unnecessary metal ions. During the last decade, there has been substantially increased interest
Yuh-Ying Yeh et al.
Oncotarget, 6(5), 2667-2679 (2015-01-19)
Flavopiridol is a small molecule inhibitor of cyclin-dependent kinases (CDK) known to impair global transcription via inactivation of positive transcription elongation factor b. It has been demonstrated to have significant activity predominantly in chronic lymphocytic leukemia and acute myeloid leukemia
Shilpa Patil et al.
Virology, 462-463, 266-272 (2014-07-08)
In the present study by examining pseudoviruses expressing patient chimeric envelopes (Envs) made between an IgG1b12 (b12)-sensitive (2-5.J3) and a b12-resistant (4.J22) HIV-1 clade C envelope, we identified determinants in the V2C2 region that governed susceptibility to b12 monoclonal antibody
Floor C J van de Watering et al.
Journal of controlled release : official journal of the Controlled Release Society, 164(3), 283-290 (2012-07-18)
Clinical application of calcium phosphate cement (CPC; with incorporated polymeric porogens) in an injectable form implicates that loading methods for growth factors are limited. In view of this, the current study evaluated the in vitro and in vivo release kinetics
Jose-Andres C Portillo et al.
Immunology, 144(1), 21-33 (2014-07-24)
Inhibition of the CD40-CD154 pathway controls inflammatory disorders. Unfortunately, administration of anti-CD154 monoclonal antibodies causes thromboembolism. Blockade of signalling downstream of CD40 may represent an approach to treat CD40-driven inflammatory disorders. Blocking tumour necrosis factor receptor-associated factor 6 (TRAF6) signalling
Piedad N De Aza et al.
Materials science & engineering. C, Materials for biological applications, 33(7), 4009-4020 (2013-08-06)
Bioceramic samples with osteogenic properties, suitable for use in the regeneration of hard tissue, were synthesized. The materials consisting of α-tricalcium phosphate (αTCP) and also αTCP doped with either 1.5 wt.% or 3.0 wt.% of dicalcium silicate (C2S) in the
Timo Brandenburger et al.
Shock (Augusta, Ga.), 42(3), 234-238 (2014-07-01)
Remote ischemic preconditioning (RIPC) is an easily applicable method for protecting the heart against a subsequent ischemia and reperfusion (I/R) injury. However, the exact molecular mechanisms underlying RIPC are unknown. We examined the involvement of microRNAs (miRNAs) and in particular
Justyna Kusek et al.
Molecular pharmacology, 87(1), 39-51 (2014-10-31)
Cell-permeable orthosteric ligands can assist folding of G protein-coupled receptors in the endoplasmic reticulum (ER); this pharmacochaperoning translates into increased cell surface levels of receptors. Here we used a folding-defective mutant of human A1-adenosine receptor as a sensor to explore
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