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Showing 1-13 of 13 results for "EHURLUC" within Papers

YAP1 Is a Driver of Myofibroblast Differentiation in Normal and Diseased Fibroblasts.

Bram Piersma et al.

The American journal of pathology, 185(12), 3326-3337 (2015-10-16)

Dupuytren disease is a fibrotic disorder characterized by contraction of myofibroblast-rich cords and nodules in the hands. The Hippo member Yes-associated protein 1 (YAP1) is activated by tissue stiffness and the profibrotic transforming growth factor-β1, but its role in cell

The small GTPase Rab29 is a common regulator of immune synapse assembly and ciliogenesis.

A Onnis et al.

Cell death and differentiation, 22(10), 1687-1699 (2015-05-30)

Accumulating evidence underscores the T-cell immune synapse (IS) as a site of intense vesicular trafficking, on which productive signaling and cell activation crucially depend. Although the T-cell antigen receptor (TCR) is known to exploit recycling to accumulate to the IS

αII-spectrin and βII-spectrin do not affect TGFβ1-induced myofibroblast differentiation.

Bram Piersma et al.

Cell and tissue research, 374(1), 165-175 (2018-05-05)

Mechanosensing of fibroblasts plays a key role in the development of fibrosis. So far, no effective treatments are available to treat this devastating disorder. Spectrins regulate cell morphology and are potential mechanosensors in a variety of non-erythroid cells, but little

PTEN loss in the fallopian tube induces hyperplasia and ovarian tumor formation.

Angela Russo et al.

Oncogene, 37(15), 1976-1990 (2018-01-26)

The signaling events involved in the onset of ovarian cancer from the fallopian tube epithelium (FTE) are crucial for early detection and treatment of the disease, but they remain poorly defined. Conditional homozygous knockout of PTEN mediated by PAX8-cre recombinase

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Targeting Nrf2 in healthy and malignant ovarian epithelial cells: Protection versus promotion.

Monique G P van der Wijst et al.

Molecular oncology, 9(7), 1259-1273 (2015-04-07)

Risk factors indicate the importance of oxidative stress during ovarian carcinogenesis. To tolerate oxidative stress, cells activate the transcription factor Nrf2 (Nfe2l2), the master regulator of antioxidant and cytoprotective genes. Indeed, for most cancers, hyperactivity of Nrf2 is observed, and

The intraflagellar transport protein IFT20 controls lysosome biogenesis by regulating the post-Golgi transport of acid hydrolases.

Francesca Finetti et al.

Cell death and differentiation, 27(1), 310-328 (2019-05-31)

The assembly and function of the primary cilium depends on multimolecular intraflagellar transport (IFT) complexes that shuttle their cargo along the axonemal microtubules through their interaction with molecular motors. The IFT system has been moreover recently implicated in a reciprocal

PPM1B depletion in U2OS cells supresses cell growth through RB1-E2F1 pathway and stimulates bleomycin-induced cell death.

Rachel Elizabeth Miller et al.

Biochemical and biophysical research communications, 500(2), 391-397 (2018-04-15)

PPM1B is a metal-dependent serine/threonine protein phosphatase, with a similar structure and function to the well-known oncogene in breast cancer, PPM1D (WIP1). However, clinical significance of PPM1B as a pharmacological target in cancer therapy has not been explored. To test

Redundancy of human ATG4 protease isoforms in autophagy and LC3/GABARAP processing revealed in cells.

Alexander Agrotis et al.

Autophagy, 15(6), 976-997 (2019-01-22)

Macroautophagy/autophagy is a cellular degradation pathway that delivers cytoplasmic material to lysosomes via double-membrane organelles called autophagosomes. Lipidation of ubiquitin-like LC3/GABARAP proteins on the autophagosome membrane is important for autophagy. The cysteine protease ATG4 executes 2 LC3/GABARAP processing events: priming

Endogenous hepcidin synthesis protects the distal nephron against hemin and hemoglobin mediated necroptosis.

Rachel P L van Swelm et al.

Cell death & disease, 9(5), 550-550 (2018-05-12)

Hemoglobinuria is associated with kidney injury in various hemolytic pathologies. Currently, there is no treatment available and its pathophysiology is not completely understood. Here we studied the potential detrimental effects of hemoglobin (Hb) exposure to the distal nephron (DN). Involvement

Proteomic analysis reveals a role for PAX8 in peritoneal colonization of high grade serous ovarian cancer that can be targeted with micelle encapsulated thiostrepton.

Laura R Hardy et al.

Oncogene, 38(32), 6003-6016 (2019-07-13)

High grade serous ovarian cancer (HGSOC) is the fifth leading cause of cancer deaths among women yet effective targeted therapies against this disease are limited. The heterogeneity of HGSOC, including few shared oncogenic drivers and origination from both the fallopian

Calpastatin ablation aggravates the molecular phenotype in cell and animal models of Huntington disease.

Jonasz Jeremiasz Weber et al.

Neuropharmacology, 133, 94-106 (2018-01-23)

Deciphering the molecular pathology of Huntington disease is of particular importance, not only for a better understanding of this neurodegenerative disease, but also to identify potential therapeutic targets. The polyglutamine-expanded disease protein huntingtin was shown to undergo proteolysis, which results

6-Dehydrogingerdione restrains lipopolysaccharide-induced inflammatory responses in RAW 264.7 macrophages.

Huang SH, Lee CH, Wang HM, et al.

Journal of Agricultural and Food Chemistry, 62(37), 9171-9179 (2014)

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